Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Tumor necrosis factor alpha (TNF-alpha) appears to play a role in the cachexia and diabetes seen in patients with cancers.
|
12378118 |
2002 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Tumor necrosis factor-alpha (TNFalpha) is a key inflammatory cytokine associated with cachexia.
|
17182869 |
2006 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
TNF-α is associated with obesity, but also with anorexia and cachexia.
|
26472017 |
2016 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Tumor necrosis factor-alpha (TNF)-cachectin increases the expression of the human immunodeficiency virus (HIV), reverses the therapeutic efficacy of zidovudine (ZDV), and may contribute to the wasting syndrome.
|
8099612 |
1993 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
A number of pro-inflammatory cytokines, like interleukin-1 (IL-1), IL-6, tumor necrosis factor- alpha (TNF-α) may have important role in the pathological mechanisms of cachexia in cancer.
|
27919820 |
2017 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Among these, tumor necrosis factor alpha (TNFα) plays a relevant role in enhancing cancer risk, cancer growth, and cancer-associated cachexia.
|
30764482 |
2019 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Animals implanted with MCF-7IL-1 alpha cells were cachetic, which correlated with increased leptin serum levels but not other known cachexia-inducing cytokines such as IL-6, tumor necrosis factor, or interferon gamma.
|
14633625 |
2003 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Because tumor necrosis factor alpha (TNF-alpha) has been implicated as a major mediator of cachexia, its effects on C2C12 myocytes were examined.
|
11344085 |
2001 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
RGD |
Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue.
|
16077938 |
2005 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Consequently, alcohol consumption neither affected cancer-associated cachexia nor decreased the survival of TNFα KO mice bearing cachectic cancer.
|
31657476 |
2020 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
DD therapy also further downregulated BALF ILs and cytokines including Jak-STAT (Janus kinases-signal transducer and activator of transcription proteins), TNFα (tumor necrosis factor-α), and T-cell receptor signaling pathways, cytokines involved in macrophage migration, eosinophil recruitment, humoral and adaptive immunity, neutrophil activation, and cachexia.
|
30965011 |
2019 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Etanercept blocks tumor necrosis factor α (TNF-α), a proinflammatory cytokine that plays a role in cancer-related cachexia and tumor growth.
|
23429495 |
2013 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Expression of a constitutively active mutant of Gα(i2) stimulated myotube growth and differentiation, effects that required the transcription factor NFAT (nuclear factor of activated T cells) and protein kinase C. In addition, expression of the constitutively active Gα(i2) mutant inhibited atrophy caused by the cachectic cytokine TNFα (tumor necrosis factor-α) by blocking an increase in the abundance of the mRNA encoding the E3 ubiquitin ligase MuRF1 (muscle ring finger 1).
|
22126963 |
2011 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
However, from various studies it has become clear that the action of TNF can only be understood in the context of simultaneous presence of other cytokines, some of which have activities that are at the least equally important as TNF in bringing about cachexia.
|
9290087 |
1997 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
However, serum TNF-α was positively associated with serum FFA in the early- but not late-stage cachexia.
|
29338749 |
2018 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Immunization with RTFP-2 also reduced the mortality of TNF-α induced cachexia from 56% to 28%.
|
22884682 |
2012 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In addition, TNF-alpha mice displayed impaired healing of incisional and excisional skin wounds, compared with control animals, before the onset of cachexia.
|
8686743 |
1996 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In this study, weight loss, body mass index, skeletal muscle index (SMI), serum carcinoembryonic antigen, serum tumor necrosis factor (TNF)-α, serum interleukin (IL)-6, serum high mobility group box (HMGB)-1, and SDS-soluble myosin light chain 1 (SDS-MYL1) of the psoas muscle were examined in 8 autopsied cases of death from colorectal cancer (CRC) as biomarkers of cachexia.
|
31707381 |
2019 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Inducible nitric oxide synthase (iNOS) has recently been shown to be an important mediator of TNFα-induced cachectic muscle loss, and studies suggest that it may also play a role in sarcopenia.
|
21832306 |
2011 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
It has further been suggested that TNF may play a role in the pathobiochemistry of CF cachexia, secondary to the localized inflammatory response in the lung or wider systemic activation of cells of the monocyte-macrophage series in response to endotoxin.
|
8217192 |
1993 |
Cachexia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
It is known TNF-α level is increased in patients with CC, and TNF-α release is triggered by ang II.
|
28161398 |
2017 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
CTD_human |
Molecular analysis of xenograft models of human cancer cachexia--possibilities for therapeutic intervention.
|
17878525 |
2007 |
Cachexia
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that elevated TNF-alpha serum level may have clinical significance in the development of cachexia in PA patients.
|
19152246 |
2009 |
Cachexia
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Since tumor necrosis factor-alpha (TNF alpha) is elevated in cachexia-associated diseases, and chronic administration of TNF alpha induces cachexia in animal models, we assessed the regulation of albumin gene expression by TNF alpha in vivo.
|
2295699 |
1990 |
Cachexia
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
The rs1799964 in the TNF gene and rs4291 in the ACE gene are new associations when the definition of cachexia is based on a combination of WL and LSMI.
|
27897403 |
2017 |