TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE Tumor necrosis factor alpha (TNF-alpha) appears to play a role in the cachexia and diabetes seen in patients with cancers. 12378118 2002
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE Tumor necrosis factor-alpha (TNFalpha) is a key inflammatory cytokine associated with cachexia. 17182869 2006
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE TNF-α is associated with obesity, but also with anorexia and cachexia. 26472017 2016
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE Tumor necrosis factor-alpha (TNF)-cachectin increases the expression of the human immunodeficiency virus (HIV), reverses the therapeutic efficacy of zidovudine (ZDV), and may contribute to the wasting syndrome. 8099612 1993
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE A number of pro-inflammatory cytokines, like interleukin-1 (IL-1), IL-6, tumor necrosis factor- alpha (TNF-α) may have important role in the pathological mechanisms of cachexia in cancer. 27919820 2017
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE Among these, tumor necrosis factor alpha (TNFα) plays a relevant role in enhancing cancer risk, cancer growth, and cancer-associated cachexia. 30764482 2019
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE Animals implanted with MCF-7IL-1 alpha cells were cachetic, which correlated with increased leptin serum levels but not other known cachexia-inducing cytokines such as IL-6, tumor necrosis factor, or interferon gamma. 14633625 2003
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE Because tumor necrosis factor alpha (TNF-alpha) has been implicated as a major mediator of cachexia, its effects on C2C12 myocytes were examined. 11344085 2001
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype RGD Cancer cachexia results in an increase in TNF-alpha receptor gene expression in both skeletal muscle and adipose tissue. 16077938 2005
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE Consequently, alcohol consumption neither affected cancer-associated cachexia nor decreased the survival of TNFα KO mice bearing cachectic cancer. 31657476 2020
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE DD therapy also further downregulated BALF ILs and cytokines including Jak-STAT (Janus kinases-signal transducer and activator of transcription proteins), TNFα (tumor necrosis factor-α), and T-cell receptor signaling pathways, cytokines involved in macrophage migration, eosinophil recruitment, humoral and adaptive immunity, neutrophil activation, and cachexia. 30965011 2019
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE Etanercept blocks tumor necrosis factor α (TNF-α), a proinflammatory cytokine that plays a role in cancer-related cachexia and tumor growth. 23429495 2013
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE Expression of a constitutively active mutant of Gα(i2) stimulated myotube growth and differentiation, effects that required the transcription factor NFAT (nuclear factor of activated T cells) and protein kinase C. In addition, expression of the constitutively active Gα(i2) mutant inhibited atrophy caused by the cachectic cytokine TNFα (tumor necrosis factor-α) by blocking an increase in the abundance of the mRNA encoding the E3 ubiquitin ligase MuRF1 (muscle ring finger 1). 22126963 2011
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE However, from various studies it has become clear that the action of TNF can only be understood in the context of simultaneous presence of other cytokines, some of which have activities that are at the least equally important as TNF in bringing about cachexia. 9290087 1997
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE However, serum TNF-α was positively associated with serum FFA in the early- but not late-stage cachexia. 29338749 2018
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE Immunization with RTFP-2 also reduced the mortality of TNF-α induced cachexia from 56% to 28%. 22884682 2012
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE In addition, TNF-alpha mice displayed impaired healing of incisional and excisional skin wounds, compared with control animals, before the onset of cachexia. 8686743 1996
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE In this study, weight loss, body mass index, skeletal muscle index (SMI), serum carcinoembryonic antigen, serum tumor necrosis factor (TNF)-α, serum interleukin (IL)-6, serum high mobility group box (HMGB)-1, and SDS-soluble myosin light chain 1 (SDS-MYL1) of the psoas muscle were examined in 8 autopsied cases of death from colorectal cancer (CRC) as biomarkers of cachexia. 31707381 2019
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE Inducible nitric oxide synthase (iNOS) has recently been shown to be an important mediator of TNFα-induced cachectic muscle loss, and studies suggest that it may also play a role in sarcopenia. 21832306 2011
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE It has further been suggested that TNF may play a role in the pathobiochemistry of CF cachexia, secondary to the localized inflammatory response in the lung or wider systemic activation of cells of the monocyte-macrophage series in response to endotoxin. 8217192 1993
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 AlteredExpression phenotype BEFREE It is known TNF-α level is increased in patients with CC, and TNF-α release is triggered by ang II. 28161398 2017
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype CTD_human Molecular analysis of xenograft models of human cancer cachexia--possibilities for therapeutic intervention. 17878525 2007
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 AlteredExpression phenotype BEFREE Our results suggest that elevated TNF-alpha serum level may have clinical significance in the development of cachexia in PA patients. 19152246 2009
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 Biomarker phenotype BEFREE Since tumor necrosis factor-alpha (TNF alpha) is elevated in cachexia-associated diseases, and chronic administration of TNF alpha induces cachexia in animal models, we assessed the regulation of albumin gene expression by TNF alpha in vivo. 2295699 1990
CUI: C0006625
Disease: Cachexia
Cachexia
0.600 GeneticVariation phenotype BEFREE The rs1799964 in the TNF gene and rs4291 in the ACE gene are new associations when the definition of cachexia is based on a combination of WL and LSMI. 27897403 2017