|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A TNF-JNK-Axl-ERK signaling axis mediates primary resistance to EGFR inhibition in glioblastoma.
|
28604685 |
2017 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that glioblastoma resistance to gefitinib may be mediated by an adaptive pro-survival TNFα-JNK-Axl signaling axis, and that high TNFα levels in the glioblastoma microenvironment may further intensify primary resistance.
|
31565489 |
2019 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells.
|
8912851 |
1996 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The current study examined the role of SphK activity in TNF-alpha-stimulated cell proliferation in 1321N1 glioblastoma cells.
|
17114809 |
2007 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Under-expression of CTGF, EPCR and TNF genes was observed in glioblastoma tumoral tissue in comparison with peritumoral brain tissue.
|
22591734 |
2012 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The highest mean values of PHLPP1 mRNA and protein were found in non-glioma brain tissues whereas the lowest mean values were found in those in glioblastoma with an increase of TNF-α, IL-17, IL-1β (p<0.05).
|
26971226 |
2016 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Microarray analysis of tumor necrosis factor alpha induced gene expression in U373 human glioblastoma cells.
|
14641910 |
2003 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Efficacy of EGFR plus TNF inhibition in a preclinical model of temozolomide-resistant glioblastoma.
|
31363754 |
2019 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Activation of NF-κB by TNFα decreases calcium induced mPTP opening, elevates mitochondrial potential and increases reactive oxygen species (ROS) production in both T98G human glioblastoma cells and rat cortical neurons.
|
28317877 |
2017 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In in vitro study, HCMV infection induced the expression of interleukin 6 and tumor necrosis factor-α in human glioblastoma U87 MG (U87) cells and human umbilical vein endothelial cells (HUVECs).
|
27474433 |
2016 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effect of a TNFα-producing adipose tissue-derived MSC (AT-MSC/hTNFα) was tested on the tumour cell lines of different origins: melanoma (A375), breast carcinoma (SKBR3, MDA-MB-231), colon carcinoma (HT29), ovarian carcinoma (SKOV3) and glioblastoma (U87-MG) cells.
|
25677845 |
2015 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of TROY (TNFRSF19), a member of the TNF receptor superfamily, inversely correlates with patient survival and stimulates glioblastoma cell migration and invasion in vitro.
|
23699535 |
2013 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This prompted us to evaluate the antitumor effects of recombinant parvoviruses designed to deliver IP-10 or TNF-alpha into a glioblastoma.
|
18670452 |
2009 |
|
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor microsatellite polymorphisms in Italian glioblastoma patients.
|
10087955 |
1999 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that anisomycin and death receptor ligand anti-Fas antibody CH-11 or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induce apoptosis in multiple human glioblastoma cell lines.
|
17699104 |
2007 |
|
Adult Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we have examined two non-chemotherapeutic agents for synergistic effects: lovastatin and Tumor Necrosis Factor (TNF)-related apoptosis-inducing ligand (TRAIL) for synergistic effects; on three human malignant glioblastoma cell lines, M059K, M59J, and A172.
|
17928957 |
2008 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inhibition of Casein kinase-2 induces p53-dependent cell cycle arrest and sensitizes glioblastoma cells to tumor necrosis factor (TNFα)-induced apoptosis through SIRT1 inhibition.
|
22318540 |
2012 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glioblastoma microenvironment contains high levels of TNFα and IL-1β, which mediate inflammation through induction of a local network of cytokines and chemokines.
|
26794430 |
2016 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transcriptional targeting of adenovirally delivered tumor necrosis factor alpha by temozolomide in experimental glioblastoma.
|
15374943 |
2004 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Modulation of proliferation and antigen expression of a cloned human glioblastoma by interleukin-4 alone and in combination with tumor necrosis factor-alpha and/or interferon-gamma.
|
8413882 |
1993 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As glioblastoma are resistant to the cytotoxic effect of TNFalpha, we investigated the potential of Ebselen in sensitizing glioma cells to TNFalpha-induced apoptosis.
|
18709644 |
2008 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These observations demonstrate that olive oil compounds inhibit the effect of the chronic inflammatory microenvironment on glioblastoma progression through TNF-α actions and may be useful in cancer chemoprevention.
|
26410343 |
2016 |
|
Adult Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using a Grade IV human glioblastoma cell line, we examined the contribution of calcium-activated K(+) channels (K(Ca) channels) to AVD after the addition of either staurosporine (Stsp) or TNF-α-related apoptosis-inducing ligand (TRAIL) to activate the intrinsic or extrinsic pathway of apoptosis, respectively.
|
22992678 |
2012 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, our data identified MAPK-ERK-YAP signaling pathways as the primary molecular mechanisms by which TNFα modulated mitochondrial fission and glioblastoma apoptosis.
|
30425514 |
2018 |
|
Adult Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We recently reported that mammalian target of rapamycin inhibitors-rapamycin, temsirolimus, torin 1, and PP242-suppressed invasion and migration promoted by tumor necrosis factor-alpha and phorbol-myristate-acetate in glioblastoma cells.
|
28351321 |
2017 |