|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Kaempferol reduced CD3<sup>+</sup> T cell infiltration and gene expression of major proinflammatory cytokines, including interleukin (IL)-6, IL-17A and tumor necrosis factor (TNF)-α, in the psoriatic skin lesion.
|
31407330 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to investigate the anti-atopic effects of UMB on 2,4-dinitrochlorobenzene (DNCB)- and house dust mite extract (Dermatophagoides farinae extract, DFE)-treated mice with AD-like skin lesions and on tumor necrosis factor (TNF)-α/interferon (IFN)-γ-treated HaCaT cells.
|
31437788 |
2019 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The following were assessed: dermatitis severity scores; ear and dorsal skin haematoxylin and eosin staining; interleukin (IL)- 1α, IL-1β, IL-2, IL-4, IL-6, and tumour necrosis factor (TNF)-α cytokine levels in the serum; spleen index; spleen CD4 + /CD8 + T lymphocyte ratio; and phosphorylation levels of mitogen-activated protein kinases (MAPKs- p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK)), IκB-α, and nuclear factor (NF)-κB (p65) in skin lesions.
|
29698775 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of TNF-α in palmoplantar pustulosis increased after anti-TNF-α therapy in the two examined patients with exacerbated skin lesions.
|
29611085 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, Tnf gene deficiency prevented skin lesions in cpdm mice.
|
21455173 |
2011 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The mRNA and protein expression levels in human and mouse skin lesions and TNF‑α‑stimulated HaCaT cells were detected using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blotting, and compared with the control groups.
|
31017270 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Treatment of K5.Stat3C mice with TNF-α or EGFR inhibitors attenuated the skin lesions, suggesting the roles of TACE substrates in psoriasis.
|
25384035 |
2014 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, Cal/BDP significantly suppressed the interleukin (IL)-23/IL-17-producing T (T17) pathogenic axis, including expression of IL-17a, IL-23a, IL-22 and TNF-α mRNA in skin lesions and expansion of CCR6<sup>+</sup> γδ T17 cells in the draining lymph nodes.
|
31705000 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
This study has the aim to identify early critical events for the resolution of inflammation in skin lesions using anti-TNF therapy.
|
23731727 |
2013 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We first found that IL-1β and TNF-α mRNA expression was significantly decreased in the skin lesions treated with DDH-1.
|
30503675 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
It was found that genistein can significantly improve IMQ-induced pathological scores of cutaneous skin lesions in mice, reduce epidermal thickness, and inhibit the expression of inflammatory factors，including interleukin (IL)-1β, IL-6, tumour necrosis factor-alpha (TNF-α), chemokine ligand 2 (CCL2), IL-17 and IL-23.
|
30743203 |
2019 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Macroscopic and microscopic evaluation of skin lesions was performed together with measurements of serum levels of interleukin (IL)-1β, IL-6, tumour necrosis factor alpha (TNF-α), IL-17, IL-22, IL-10 and IL-4.
|
29409331 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Administration of CK onto DNCB-induced AD-like skin lesions in NC/Nga mice ameliorated lesion intensity scores, levels of IgE, thymus and activation-regulated chemokine (TARC), TNF-α, and IL-4 in serum and ears.
|
22407167 |
2012 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lesion size reduction was associated with reduced expression of IRS-1 (P < 0.01), TNFα (P < 0.0001), and vascular endothelial growth factor (P < 0.01); reduced keratinocyte proliferation (P < 0.01); and the restoration (P < 0.02) of normal levels of infiltrating CD4(+) and CD3(+) lymphocytes in psoriatic skin lesions.
|
24504098 |
2014 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
After 1 year's treatment, the skin lesions exhibited a reduction in granulomas, and a concomitant reduction in deposits of TNF-alpha.
|
9115924 |
1997 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Oral administration of L. chungangensis CAU 28(T) suppressed the production of IL-4, IL-5, IL-12, IFN-γ, tumor necrosis factor-α, and thymus- and activation-regulated chemokine (TARC) in skin lesions, indicating that it strongly drives the local immune system with efficacy comparable to that of tacrolimus, a topical immunomodulatory drug used for the treatment of atopic dermatitis.
|
27289147 |
2016 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
CRT effectively mitigated the secretion of pro‑inflammatory cytokines, including tumor necrosis factor‑α and interleukin 1β, as well as immune cell infiltration into skin lesions in a mouse model of AD‑like skin disease induced by dinitrochlorobenzene.
|
29845271 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SP treatment significantly reduced the infiltration of mast cells and CD3-positive T cells as well as inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and thymic stromal lymphopoietin (TSLP), in AD-like skin lesions and decreased the levels of IgE and thymus and activation-regulated chemokine in serum.
|
28833499 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
After 1 month of prednisolone treatment the sizes of the skin granulomas were reduced, as were the grades of cells positive for TNF-alpha and IL-10 in skin lesions.
|
15908402 |
2005 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, the anti‑AD effects of a 70% ethanol extract of TAEE were investigated in 2,4‑dinitrochlorobenzene (DNCB)‑treated mice with AD‑like skin lesions and in tumor necrosis factor (TNF)‑α‑ and interferon (IFN)‑γ‑stimulated human keratinocytes (HaCaT cells).
|
30066901 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The effect of CCE on mite antigen-treated NC/Nga mice was evaluated by examining skin symptom severity, levels of serum IgE, tumor necrosis factor-α (TNF-α), and histamine, skin histology, and mRNA expression of cytokines in the skin lesions.
|
21035532 |
2011 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The mRNA expression in blood and skin lesion for TNF, IFN-γ, IL-1β, IL-6, and IL-17A significantly reduced in patients with ENL after treatment, while mRNA expression for IL-10 and TGF-β was significantly increased both in blood and skin lesion after treatment.
|
29479352 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression levels of PGRN and TNF-α were elevated in LSc skin lesions compared with healthy control skin.
|
30268392 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, C5aR1 deficiency significantly decreased IMQ-induced infiltration of plasmacytoid dendritic cells (pDCs), monocytes and neutrophils in psoriatic skin lesions and functions of pDCs, evidenced by the remarkable reduction in the IMQ-induced production of interferon-α (IFN-α) and tumor necrosis factor α (TNF-α), and FMS-like tyrosine kinase 3 ligand (FLT3L)-dependent pDCs differentiation.
|
31447855 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Treatment with antibody to TNF-alpha prevented death, resulted in near normal growth, and produced a marked decrease in skin lesions and a profound reduction in the expression of HIV-1 mRNA and gp120.
|
12388730 |
2002 |