|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
After 1 year's treatment, the skin lesions exhibited a reduction in granulomas, and a concomitant reduction in deposits of TNF-alpha.
|
9115924 |
1997 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Treatment with antibody to TNF-alpha prevented death, resulted in near normal growth, and produced a marked decrease in skin lesions and a profound reduction in the expression of HIV-1 mRNA and gp120.
|
12388730 |
2002 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Two control groups were assessed for B19 and TNF expression comprising one with irrelevant primers and the other representing 18 cases of inflammatory skin lesions where the etiology was known and unrelated to B19 infection.
|
14675284 |
2004 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
After 1 month of prednisolone treatment the sizes of the skin granulomas were reduced, as were the grades of cells positive for TNF-alpha and IL-10 in skin lesions.
|
15908402 |
2005 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
High levels of interleukin (IL)-1beta, IL-4, IL-5, IL-6, IL-8, IL-10, IL-13, tumour necrosis factor (TNF)-alpha and interferon (IFN)-gamma have been detected in skin lesions or sera of patients with BP.
|
16403098 |
2006 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The present study was designed to investigate the effects of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha on RIG-I expression in human keratinocytes, and the expression of RIG-I in skin lesions of psoriasis vulgaris, in which IFN-gamma and TNF-alpha are considered to be involved in its pathogenesis.
|
17182220 |
2007 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
The prevalence of immunoreactant deposits in the skin lesions measured by DIF was 54.7% (35 of 64 patients).
|
19839494 |
2009 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Importantly, Tnf gene deficiency prevented skin lesions in cpdm mice.
|
21455173 |
2011 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The effect of CCE on mite antigen-treated NC/Nga mice was evaluated by examining skin symptom severity, levels of serum IgE, tumor necrosis factor-α (TNF-α), and histamine, skin histology, and mRNA expression of cytokines in the skin lesions.
|
21035532 |
2011 |
|
Skin lesion
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Individuals with GA/AA (-308 TNF-α) and TA/AA (-3575 IL10) genotypes were at higher risk of developing arsenic-induced skin lesions, ocular, and respiratory diseases.
|
21357384 |
2011 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Upregulation and nuclear localization of TNF-like cytokine 1A (TL1A) and its receptors DR3 and DcR3 in psoriatic skin lesions.
|
21672030 |
2011 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Administration of CK onto DNCB-induced AD-like skin lesions in NC/Nga mice ameliorated lesion intensity scores, levels of IgE, thymus and activation-regulated chemokine (TARC), TNF-α, and IL-4 in serum and ears.
|
22407167 |
2012 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
This study has the aim to identify early critical events for the resolution of inflammation in skin lesions using anti-TNF therapy.
|
23731727 |
2013 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
On the other hand, high TNF levels can contribute to tissue damage, consequently leading to skin lesions.
|
23068083 |
2013 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Cultivated ginseng inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-α/IFN-γ-induced TARC activation in HaCaT cells.
|
23454147 |
2013 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Treatment of K5.Stat3C mice with TNF-α or EGFR inhibitors attenuated the skin lesions, suggesting the roles of TACE substrates in psoriasis.
|
25384035 |
2014 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lesion size reduction was associated with reduced expression of IRS-1 (P < 0.01), TNFα (P < 0.0001), and vascular endothelial growth factor (P < 0.01); reduced keratinocyte proliferation (P < 0.01); and the restoration (P < 0.02) of normal levels of infiltrating CD4(+) and CD3(+) lymphocytes in psoriatic skin lesions.
|
24504098 |
2014 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Neutralization of tumor necrosis factor-α and IL-6 (both downstream of IL-17A) reduced skin lesions, attenuated oxidative stress in heart and blood, and partially improved endothelial dysfunction in K14-IL-17A(ind/+) mice.
|
25341795 |
2014 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Oral administration of L. chungangensis CAU 28(T) suppressed the production of IL-4, IL-5, IL-12, IFN-γ, tumor necrosis factor-α, and thymus- and activation-regulated chemokine (TARC) in skin lesions, indicating that it strongly drives the local immune system with efficacy comparable to that of tacrolimus, a topical immunomodulatory drug used for the treatment of atopic dermatitis.
|
27289147 |
2016 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The following were assessed: dermatitis severity scores; ear and dorsal skin haematoxylin and eosin staining; interleukin (IL)- 1α, IL-1β, IL-2, IL-4, IL-6, and tumour necrosis factor (TNF)-α cytokine levels in the serum; spleen index; spleen CD4 + /CD8 + T lymphocyte ratio; and phosphorylation levels of mitogen-activated protein kinases (MAPKs- p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK)), IκB-α, and nuclear factor (NF)-κB (p65) in skin lesions.
|
29698775 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We first found that IL-1β and TNF-α mRNA expression was significantly decreased in the skin lesions treated with DDH-1.
|
30503675 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Macroscopic and microscopic evaluation of skin lesions was performed together with measurements of serum levels of interleukin (IL)-1β, IL-6, tumour necrosis factor alpha (TNF-α), IL-17, IL-22, IL-10 and IL-4.
|
29409331 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
CRT effectively mitigated the secretion of pro‑inflammatory cytokines, including tumor necrosis factor‑α and interleukin 1β, as well as immune cell infiltration into skin lesions in a mouse model of AD‑like skin disease induced by dinitrochlorobenzene.
|
29845271 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SP treatment significantly reduced the infiltration of mast cells and CD3-positive T cells as well as inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and thymic stromal lymphopoietin (TSLP), in AD-like skin lesions and decreased the levels of IgE and thymus and activation-regulated chemokine in serum.
|
28833499 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, the anti‑AD effects of a 70% ethanol extract of TAEE were investigated in 2,4‑dinitrochlorobenzene (DNCB)‑treated mice with AD‑like skin lesions and in tumor necrosis factor (TNF)‑α‑ and interferon (IFN)‑γ‑stimulated human keratinocytes (HaCaT cells).
|
30066901 |
2018 |