Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE This study was designed to detect wether the TNF2 allele is associated with disease progression in MS. We examined the TNFalpha -308 polymorphism with an allelic discrimination PCR to detect the G-->A transition in the genomic DNA of 283 MS patients from Germany and in 72 patients with amyotrophic lateral sclerosis (ALS) and 66 with stroke from the same genetic background who served as controls. 10552245 1999
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group CTD_human The novel beta-blocker, carvedilol, provides neuroprotection in transient focal stroke. 10950380 2000
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE Possession of the TNF-alpha T allele significantly increases the risk of vascular dementia, and increases the risk of Alzheimer's disease associated with apolipoprotein E. Although further research is needed, these findings suggest a potential role for anti-inflammatory therapy in vascular dementia and Alzheimer's disease, and perhaps especially in patients who have had a stroke. 11273064 2001
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group LHGDN The release of tumor necrosis factor-alpha is associated with ischemic tolerance in human stroke. 14681891 2003
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Cells that are resistant to apoptosis by Par-4 alone, however, are greatly sensitized by Par-4 to the action of other pro-apoptotic insults such as growth factor withdrawal, tumor necrosis factor, ionizing radiation, intracellular calcium elevation, or those involved in neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and stroke. 12565819 2003
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE The combination of TNF (-308)GG homozygosity and the IL4R 503P variant carrier status was associated with a particularly strong predisposition to LV stroke (odds ratio [OR] = 5.5; 95% confidence interval [CI] = 2.3-13.1). 14615367 2004
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group LHGDN Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-alpha genes, but not the interleukin-1beta gene. 15036607 2004
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE There is increasing evidence on the role of proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the occurrence and outcome of stroke. 15733973 2005
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE It was examined whether G to A promoter polymorphism in the tumor necrosis factor-alpha gene at position -308 affects the risk of stroke. 16473522 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes. 16879054 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group LHGDN Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes. 16879054 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE We investigated whether gradual increases in tumor necrosis factor-alpha (TNF-alpha) reported during exercise down-regulates expression of TNF-alpha receptors I and II (TNFRI and II) in stroke, leading to reduced brain damage. 17109621 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE The aim of this replication study was to confirm our previous findings of associations between the TNF(-308) G/A, IL4R 503 S/P, and ADRB2 27 Q/E polymorphisms and large vessel stroke risk. 17600229 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group LHGDN Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and ischemic stroke: a meta-analysis. 17452160 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group LHGDN The aim of this replication study was to confirm our previous findings of associations between the TNF(-308) G/A, IL4R 503 S/P, and ADRB2 27 Q/E polymorphisms and large vessel stroke risk. 17600229 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE IL-6, CRP, IL-10, and TNF superfamily gene variation was not associated with MI or stroke risk. 17981284 2008
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE In inflammatory cytokines, increased cytokines [including interleukin (IL) 1beta, IL-18, tumor necrosis factor alpha] after stroke lead to depression. 19891854 2009
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Tumor necrosis factor- alpha (TNF-alpha), an important immune mediator, may contribute to the initiation and progression in the stroke. 19168815 2009
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group RGD Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns. 21171972 2010
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Up-regulated TNF-α expression has also been found in various neurodegenerative diseases such as cerebral malaria, AIDS dementia, Alzheimer's disease, multiple sclerosis, and stroke, suggesting a potential pathogenic role of TNF-α in these diseases as well. 21298033 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE The aim of this study was to evaluate the association of genetic variants within the genes encoding tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-3 (MMP-3), with stroke. 21219546 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE We investigated the role of inflammatory genes IL1B, IL6, MPO, and TNF in stroke susceptibility and recovery in a population sample of 672 patients and 530 controls, adjusting for demographic, clinical and lifestyle risk factors, and stroke severity parameters. 21407237 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE Recent reports suggested that tumor necrosis factor-α (TNF-α) (-308) polymorphism is an important risk factor for stroke in children with SCA. 21160173 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE These findings strongly implicate the involvement of TNF-α in the pathogenesis of stroke. 23050663 2012
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Polymorphic variants in genes encoding apoptotic proteins, either from the extrinsic (FAS, TNF-α, CASP8) or the intrinsic (BAX, BCL2, CASP3, CASP9) pathways could be highly valuable in the diagnosis of neurodegenerative diseases and stroke. 22695677 2013