Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE The aim of this replication study was to confirm our previous findings of associations between the TNF(-308) G/A, IL4R 503 S/P, and ADRB2 27 Q/E polymorphisms and large vessel stroke risk. 17600229 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE TNF-α and PON total methylation levels correlated each other (r = 0.44; p = 0.031), especially in stroke patients (r = 0.72; p = 0.008). 24500802 2014
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Tumor necrosis factor, which exists both as a soluble (solTNF) and a transmembrane (tmTNF) protein, plays an important role in post-stroke inflammation. 31440125 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE <b>Background:</b> Tumor necrosis factor-a-induced protein 8-like 2 (TIPE2) is a novel regulator of immunity and protects against experimental stroke. 30588195 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE These findings indicate the important roles that TNF-α and IL-1β serum levels play regarding the risk of PSD, particularly during the acute phase of stroke and in patients with genetic susceptibility. 28844626 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE These data provide evidence that serum TNF-α and IL-1β concentrations are related to poor long-term outcomes after stroke in the presence of particular alleles. 29161722 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Up-regulated TNF-α expression has also been found in various neurodegenerative diseases such as cerebral malaria, AIDS dementia, Alzheimer's disease, multiple sclerosis, and stroke, suggesting a potential pathogenic role of TNF-α in these diseases as well. 21298033 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE In inflammatory cytokines, increased cytokines [including interleukin (IL) 1beta, IL-18, tumor necrosis factor alpha] after stroke lead to depression. 19891854 2009
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE It was examined whether G to A promoter polymorphism in the tumor necrosis factor-alpha gene at position -308 affects the risk of stroke. 16473522 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Quantitative assessment of stroke outcome was evaluated by measuring infarct volume (by magnetic resonance imaging), cerebral blood flow (by laser speckle imaging), neurological and sensory-motor outcome, and postischemic thrombo-inflammation (platelet thrombi, fibrin, neutrophil, phospho-NFκB [nuclear factor κB], TNFα [tumor necrosis factor α], and IL1β [interleukin 1β]). 30909835 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE The aim of this study was to evaluate the association of genetic variants within the genes encoding tumor necrosis factor-α (TNF-α) and matrix metalloproteinase-3 (MMP-3), with stroke. 21219546 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE There is increasing evidence on the role of proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the occurrence and outcome of stroke. 15733973 2005
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Stroke survivors (50-76 years) underwent a fasting blood draw for measurement of TNF-α, IL-6, CRP, serum amyloid A, sICAM-1, sVCAM-1, and bilateral vastus lateralis biopsies before and after RT. 27955950 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Serum levels of TNF-α, C-reactive protein (CRP), IL-4, IL-6, IL-10, IL-17, IL-23, and TGF-β increased, whereas serum level of IFN-γ decreased at all time points after stroke. 27682880 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE This study suggests that delirium is not scarce in patients with AIS admitted to the non-intensive stroke unit, and that delirium developing after AIS seems not to be associated with serum TNF-alpha, IL-1 beta, IL-18, BDNF and NSE but is associated with length of hospital stay and stroke severity. 27816188 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes. 16879054 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Quantitative PCR analysis of whole cell lysate as well as flow-sorted myeloid cells from the perilesional cortex showed increased cellular interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) mRNA levels but reduced plasma levels of these cytokines in MS P2X4R KO mice after stroke. 28751018 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE We investigated the role of inflammatory genes IL1B, IL6, MPO, and TNF in stroke susceptibility and recovery in a population sample of 672 patients and 530 controls, adjusting for demographic, clinical and lifestyle risk factors, and stroke severity parameters. 21407237 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Moreover, plasma H19 levels showed a positive correlation with National Institute of Health Stroke Scale score and tumor necrosis factor-α levels. 28630232 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE <b>Results:</b> MCAo resulted in profound attenuation of immune activation, as anticipated. t-PA treatment not only worsened neurological deficit, but further reduced lymphocyte and monocyte counts in blood, enhanced plasma levels of both IL-10 and TNFα and decreased various conventional DC subsets in the spleen and cLN, consistent with enhanced immunosuppression and systemic inflammation after stroke. 30972077 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE This study was designed to detect wether the TNF2 allele is associated with disease progression in MS. We examined the TNFalpha -308 polymorphism with an allelic discrimination PCR to detect the G-->A transition in the genomic DNA of 283 MS patients from Germany and in 72 patients with amyotrophic lateral sclerosis (ALS) and 66 with stroke from the same genetic background who served as controls. 10552245 1999
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE The combination of TNF (-308)GG homozygosity and the IL4R 503P variant carrier status was associated with a particularly strong predisposition to LV stroke (odds ratio [OR] = 5.5; 95% confidence interval [CI] = 2.3-13.1). 14615367 2004
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Polymorphic variants in genes encoding apoptotic proteins, either from the extrinsic (FAS, TNF-α, CASP8) or the intrinsic (BAX, BCL2, CASP3, CASP9) pathways could be highly valuable in the diagnosis of neurodegenerative diseases and stroke. 22695677 2013
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Cells that are resistant to apoptosis by Par-4 alone, however, are greatly sensitized by Par-4 to the action of other pro-apoptotic insults such as growth factor withdrawal, tumor necrosis factor, ionizing radiation, intracellular calcium elevation, or those involved in neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and stroke. 12565819 2003
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE We demonstrate that therapeutic approaches targeting synergistic IL-17 and tumor necrosis factor-α pathways in parallel offer additional neuroprotection in stroke. 28611085 2017