TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE <b>Background:</b> Tumor necrosis factor-a-induced protein 8-like 2 (TIPE2) is a novel regulator of immunity and protects against experimental stroke. 30588195 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE <b>Results:</b> MCAo resulted in profound attenuation of immune activation, as anticipated. t-PA treatment not only worsened neurological deficit, but further reduced lymphocyte and monocyte counts in blood, enhanced plasma levels of both IL-10 and TNFα and decreased various conventional DC subsets in the spleen and cLN, consistent with enhanced immunosuppression and systemic inflammation after stroke. 30972077 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Stroke survivors (50-76 years) underwent a fasting blood draw for measurement of TNF-α, IL-6, CRP, serum amyloid A, sICAM-1, sVCAM-1, and bilateral vastus lateralis biopsies before and after RT. 27955950 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Tumor necrosis factor- alpha (TNF-alpha), an important immune mediator, may contribute to the initiation and progression in the stroke. 19168815 2009
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE TNF-α and PON total methylation levels correlated each other (r = 0.44; p = 0.031), especially in stroke patients (r = 0.72; p = 0.008). 24500802 2014
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Tumor necrosis factor (TNF) has been shown to be involved in the pathogenesis of hemorrhagic stroke, having deleterious effects on cerebral arteries by promoting inflammation and apoptosis in vascular and immune cells. 27809686 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Tumor necrosis factor, which exists both as a soluble (solTNF) and a transmembrane (tmTNF) protein, plays an important role in post-stroke inflammation. 31440125 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Alveolar macrophages and epithelial and endothelial cells of Sham and Stroke animals were also isolated for evaluation of mRNA expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-α. 30290827 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Cells that are resistant to apoptosis by Par-4 alone, however, are greatly sensitized by Par-4 to the action of other pro-apoptotic insults such as growth factor withdrawal, tumor necrosis factor, ionizing radiation, intracellular calcium elevation, or those involved in neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and stroke. 12565819 2003
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE Cumulative incidence of stroke was significantly higher for children with TNF-α A allele (p=0.02) and lower for children with HBA deletion (p=0.02). 25175566 2015
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group RGD Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns. 21171972 2010
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group LHGDN Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and ischemic stroke: a meta-analysis. 17452160 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes. 16879054 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group LHGDN Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes. 16879054 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE IL-6, CRP, IL-10, and TNF superfamily gene variation was not associated with MI or stroke risk. 17981284 2008
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE In inflammatory cytokines, increased cytokines [including interleukin (IL) 1beta, IL-18, tumor necrosis factor alpha] after stroke lead to depression. 19891854 2009
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Injection of lentiviral miR-126-5p improved behavioral outcomes at 3 days after stroke (<i>P</i><0.05). miR-126-3p and -5p overexpression downregulated the expression of proinflammatory cytokines IL-1β and TNF-α and adhesion molecules VCAM-1 and E-selectin, as well as decreased MPO<sup>+</sup> (myeloperoxidase positive) cell numbers at 3 days after ischemia (<i>P</i><0.05). 31822249 2020
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE It was examined whether G to A promoter polymorphism in the tumor necrosis factor-alpha gene at position -308 affects the risk of stroke. 16473522 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Moreover, plasma H19 levels showed a positive correlation with National Institute of Health Stroke Scale score and tumor necrosis factor-α levels. 28630232 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Patients with first-in-life stroke were analysed according to: plasma concentration of the following markers on the first day of stroke: interleukin 2 (IL-2) and interleuki 6 (IL-6), S100B, tumor necrosis factor-α (TNF-α), progranulin (GRN), neuron specific enolase (NSE), urokinase-type plasminogen activator (uPA), vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), C-reactive protein (CRP), leucocyte and thrombocyte counts; their neurological status on the first day of stroke (NIHSS) and their functional status at 30 days following stroke (mRS). 31356182 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Polymorphic variants in genes encoding apoptotic proteins, either from the extrinsic (FAS, TNF-α, CASP8) or the intrinsic (BAX, BCL2, CASP3, CASP9) pathways could be highly valuable in the diagnosis of neurodegenerative diseases and stroke. 22695677 2013
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE Possession of the TNF-alpha T allele significantly increases the risk of vascular dementia, and increases the risk of Alzheimer's disease associated with apolipoprotein E. Although further research is needed, these findings suggest a potential role for anti-inflammatory therapy in vascular dementia and Alzheimer's disease, and perhaps especially in patients who have had a stroke. 11273064 2001
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Primary rat neuronal cells were subjected to a 90-minute HBOT treatment at 2.5 absolute atmospheres prior to either tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS) injury to simulate the inflammation-plagued secondary cell death associated with stroke and traumatic brain injury (TBI). 30972972 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Quantitative assessment of stroke outcome was evaluated by measuring infarct volume (by magnetic resonance imaging), cerebral blood flow (by laser speckle imaging), neurological and sensory-motor outcome, and postischemic thrombo-inflammation (platelet thrombi, fibrin, neutrophil, phospho-NFκB [nuclear factor κB], TNFα [tumor necrosis factor α], and IL1β [interleukin 1β]). 30909835 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Quantitative PCR analysis of whole cell lysate as well as flow-sorted myeloid cells from the perilesional cortex showed increased cellular interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) mRNA levels but reduced plasma levels of these cytokines in MS P2X4R KO mice after stroke. 28751018 2017