Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE This study aimed to assess serum irisin level in myocardial infarction (MI) with or without heart failure (HF) and the possible relation between irisin and cardiac markers, tumor necrosis factor-α (TNF-α) and lipid profile. 30958967 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE Individual alleles and haplotypes were studied for association with levels of the inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6, and C-reactive protein and risk for MI. 17002900 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease CTD_human Effects of carvedilol on cardiac cytokines expression and remodeling in rat with acute myocardial infarction. 16310260 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease RGD Tumour necrosis factor-α and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats. 21362018 2011
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE The expression of IL-6, TNF-α, and inflammatory related molecules ICAM-1, VCAM-1, MMP-2 and -9, nuclear NF-kB, and iNOS, were elevated in MI-V. 30642049 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Serum levels of tumor necrosis factor (TNF) rise with aging and have been correlated with the incidence of myocardial infarction. 20421368 2010
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE IL-6, CRP, IL-10, and TNF superfamily gene variation was not associated with MI or stroke risk. 17981284 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE The MI group produced a significant increase in myocardial infarct size, serum cardiac biomarkers (LDH and CK-MB), proinflammatory cytokines (TNF-α and IL-6), and MDA levels, and a significant decrease in SOD level compared with the sham group. 31280453 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE The probability of MI was lower in TNF inhibitor responders compared with non-responders (p = .001). 27881030 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Moreover, S+MI group, but not S alone, showed a significant increase in the expression of connective tissue growth factor (CTGF) and fibrotic proteins fibronectin (FN) and <i>α</i>-smooth muscle actin (SMA), in comparison to controls, in addition to a significant increase in mRNA levels of IL-6 and TNF-<i>α</i> inflammatory markers. 29177025 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE In vivo, echocardiography was performed on rats with induced MI after their treatment with TNF-α and hypoxia-induced secretome. 29258676 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease LHGDN Acute myocardial infarction and proinflammatory gene variants. 18056971 2007
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Furthermore, pretreated group showed decreased activation of TNF-α, Caspase-3 activity along with reduction in the myocardial infarct size. 31630586 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE Using a tumor necrosis factor (TNF)-α-induced bone marrow (BM)-MSC injury model in vitro and a rat MI model in vivo, we showed in the current study that miR-23a was involved in TNF-α-induced BM-MSC apoptosis through regulating caspase-7 and that the injection of BM-MSCs overexpressing miR-23a could improve left ventricular (LV) function and reduce infarct size in the rat MI model. 24269648 2014
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Notably, ACE2 overexpression significantly reduced the MI-induced increase in apoptosis, macrophage infiltration, and HMGB1 and proinflammatory cytokine expression (TNF-α and IL-6). 26498282 2016
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE We investigated the possibility that single nucleotide polymorphisms of the genes encoding TNF-alpha (-863C/A, -308G/A), LT-alpha (252G/A), and IL-10 (-1082G/A, -819C/T, and -592C/A) are associated with the incidence of restenosis, death, or myocardial infarction (MI) after coronary stenting. 14572794 2003
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE We generated tDCs by treating bone marrow-derived dendritic cells with tumor necrosis factor-α and cardiac lysate from MI mice. 28174192 2017
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE The aim of the study was to assess whether these IL-10 and TNF gene polymorphisms are related to the risk of coronary artery disease (CAD) and myocardial infarction (MI). 11689215 2001
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Gambogic acid suppressed the activation of interleukin (IL)-6 and tumor necrosis factor-α, and increased IL-10 levels in MI rats. 29434760 2018
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE C1q/TNF-related protein-9 promotes macrophage polarization and improves cardiac dysfunction after myocardial infarction. 30953351 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE Adult male wild-type C57BL/6 mice, Foxp3-diphtheria toxin receptor transgenic mice, and tumor necrosis factor (TNF) α receptor-1 (TNFR1)<sup>-</sup><sup>/-</sup> mice underwent nonreperfused myocardial infarction to induce HF or sham operation. 30586716 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Dietary supplementation with flaxseed, ALA or SDG before and after the induction of the MI significantly reduced the incidence of arrhythmias and resulted in significantly smaller infarct size, less left ventricle dilation, and decreased myocardial fibrosis and tumor necrosis factor-α levels compared to the control MI group. 31284167 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE We investigated the association between variants of rs4918 and parameters of obesity, lipid status, tumor necrosis factor-α (TNFα), adipokines (adiponectin, resistin, leptin), and insulin resistance in healthy persons and in patients with previous myocardial infarction. 27487851 2016
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE Further experiment indicated that SAL treatment reduced inflammatory factors such as IL-1β, IL-6, and TNF-α and decreased tunnel-positive cells and pro-apoptotic Bax after MI. 31811327 2019
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE CCNP was more efficient than CC in limiting the increase in inflammatory cytokine levels (such as TNF-<i>α</i>, IL-6, IL-1<i>α</i>, IL-1<i>β</i>, MCP-1, and RANTES) after MI. 31205590 2019