TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE Gene polymorphisms in the TNF locus and the risk of myocardial infarction. 11113269 2000
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE The CD14 CC genotype was associated with incidence of new coronary occlusion (P=0.026); TNF-alpha AA genotype with history of myocardial infarction (MI, P=0.04), and A allele with total occlusions at baseline (P=0.027), and systolic blood pressure (P=0.046); and IL-6-174 CC genotype with baseline minimum lumen diameter (P=0.043) and reduction in lipoprotein(a) with fluvastatin (P=0.03). 11199329 2000
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE The expression of TNF-alpha, iNOS, VEGF(164) and VEGF(188) was observed during the whole period after myocardial infarction (on days 1, 4, 11, 28 and 40), whereas VEGF(120) was found only on day 1 and 4. 11399901 2001
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE The aim of the study was to assess whether these IL-10 and TNF gene polymorphisms are related to the risk of coronary artery disease (CAD) and myocardial infarction (MI). 11689215 2001
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE Since the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha) may play a major role in the pathophysiology of acute coronary syndromes, 299 consecutive male patients hospitalized for coronary artery disease (i.e., lumen lost > or = 50%) were genotyped for the functional -308G/A TNF-alpha polymorphism using restriction fragment length polymorphism method, in order to evaluate its potential association with the risk of unstable angina and/or myocardial infarction. 12747595 2003
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE We investigated the possibility that single nucleotide polymorphisms of the genes encoding TNF-alpha (-863C/A, -308G/A), LT-alpha (252G/A), and IL-10 (-1082G/A, -819C/T, and -592C/A) are associated with the incidence of restenosis, death, or myocardial infarction (MI) after coronary stenting. 14572794 2003
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease CTD_human Simvastatin regulates myocardial cytokine expression and improves ventricular remodeling in rats after acute myocardial infarction. 15883752 2005
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease LHGDN Elevated TNF-alpha levels are associated with increased MI risk. 16243340 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Elevated TNF-alpha levels are associated with increased MI risk. 16243340 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease CTD_human Effects of carvedilol on cardiac cytokines expression and remodeling in rat with acute myocardial infarction. 16310260 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE HSP70 levels were positively correlated with monocyte TLR4, plasma interleukin-6 and tumor necrosis factor-alpha levels in AMI patients. 16714144 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease LHGDN Increased TNF-alpha and decreased TGF-beta expression in peripheral blood leukocytes after acute myocardial infarction. 16718633 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE Individual alleles and haplotypes were studied for association with levels of the inflammatory cytokines tumor necrosis factor-alpha (TNF-alpha), interleukin-6, and C-reactive protein and risk for MI. 17002900 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE IL-6, CRP, IL-10, and TNF superfamily gene variation was not associated with MI or stroke risk. 17981284 2008
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease LHGDN Acute myocardial infarction and proinflammatory gene variants. 18056971 2007
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Serum levels of tumor necrosis factor (TNF) rise with aging and have been correlated with the incidence of myocardial infarction. 20421368 2010
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease RGD Tumour necrosis factor-α and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats. 21362018 2011
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE In conclusion, we can state that TNF-α A allele might be associated with myocardial infarction. 21380730 2011
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE Depression after myocardial infarction: TNF-α-induced alterations of the blood-brain barrier and its putative therapeutic implications. 23415700 2013
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE Using a tumor necrosis factor (TNF)-α-induced bone marrow (BM)-MSC injury model in vitro and a rat MI model in vivo, we showed in the current study that miR-23a was involved in TNF-α-induced BM-MSC apoptosis through regulating caspase-7 and that the injection of BM-MSCs overexpressing miR-23a could improve left ventricular (LV) function and reduce infarct size in the rat MI model. 24269648 2014
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE Uncontrolled hyperglycemia accelerates endothelial damage and vascular inflammation caused by proinflammatory cytokines including tumor necrosis factor α (TNFα), which leads to arteriosclerotic cardiovascular diseases such as myocardial infarction. 26455386 2016
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 AlteredExpression disease BEFREE Notably, ACE2 overexpression significantly reduced the MI-induced increase in apoptosis, macrophage infiltration, and HMGB1 and proinflammatory cytokine expression (TNF-α and IL-6). 26498282 2016
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 Biomarker disease BEFREE The serum levels of cardiac troponin I (cTnI) and tumor necrosis factor-α (TNF-α), and myocardial infarct size were measured. 26648172 2016
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE We investigated the association between variants of rs4918 and parameters of obesity, lipid status, tumor necrosis factor-α (TNFα), adipokines (adiponectin, resistin, leptin), and insulin resistance in healthy persons and in patients with previous myocardial infarction. 27487851 2016
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction
0.600 GeneticVariation disease BEFREE The overall results showed that there was no significant association between TNF-α G-308A polymorphism and MI risk [A vs G: OR = 1.18, 95%CI = 0.94-1.48; AA vs GG: OR = 1.23, 95%CI = 0.74-2.05; GA vs GG: OR = 1.22, 95%CI = 0.98-1.51; (GA+AA) vs G: OR = 1.21, 95%CI = 0.96-1.54; AA vs (GG+GA): OR = 1.16, 95%CI = 0.72-1.88]. 27706628 2016