TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype BEFREE Tumour necrosis factor-alpha (TNF) is a major mediator of diverse pathophysiological events similar to those of haemolytic transfusion reactions (HTR), such as fever, intravascular coagulation and organ failure. 1911345 1991
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype BEFREE These results suggest that the evaluation of TNF/cachectin and LT production in lymphomas may help to elucidate the mechanisms of tumoral fever and cachexia. 2302463 1990
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype BEFREE Tumor necrosis factor shares with IL-1 many of the systemic and local effects of IL-1; these include fever, acute phase protein synthesis and sleep. 3127333 1987
CUI: C0015967
Disease: Fever
Fever
0.400 GeneticVariation phenotype BEFREE Vaccinia virus serpin B13R (SPI-2) inhibits interleukin-1beta-converting enzyme and protects virus-infected cells from TNF- and Fas-mediated apoptosis, but does not prevent IL-1beta-induced fever. 9049422 1997
CUI: C0015967
Disease: Fever
Fever
0.400 AlteredExpression phenotype BEFREE Tumor necrosis factor in Plasmodium falciparum malaria: high plasma level is associated with fever, but high production capacity is associated with rapid fever clearance. 9110145 1997
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype BEFREE These results suggest that superoxide free radicals or their reaction products are responsible for much of the synergistic cytotoxicity of TNF-alpha and hyperthermia. 9157996 1997
CUI: C0015967
Disease: Fever
Fever
0.400 GeneticVariation phenotype BEFREE The two infants homozygous for the TNF alpha promoter allele 2 had both a much higher incidence of fever, independently of parasitaemia, than the average for the other genotypes. 10223213 1999
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype CTD_human Absence of severe systemic toxicity after leakage-controlled isolated limb perfusion with tumor necrosis factor-alpha and melphalan. 10379864 1999
CUI: C0015967
Disease: Fever
Fever
0.400 AlteredExpression phenotype BEFREE The threshold temperature for the onset of apoptosis was 42 degrees C. Whereas hyperthermia exerted no effect on the expression of Bcl-2 and Bax, heat induced a >30-fold increase of tumor necrosis factor (TNF) alpha mRNA expression and a significant increase in TNF-alpha protein secretion. 10416602 1999
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype BEFREE On the other hand, increased expression of Mn-SOD can diminish the cytotoxic effects of several anticancer modalities, including tumor necrosis factor alpha, ionizing radiation, certain chemotherapeutic agents and hyperthermia. 10853026 2000
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype BEFREE Lymphocytes infiltrating damaged tissues might be responsible for the disease through secretion of cytokines, such as tumor necrosis factor (TNF)-alpha, that could cause fever, as well as endothelial tissue damage. 10997339 2000
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype BEFREE Reconstitution of MnSOD expression in several human cancer cell lines leads to reversion of malignancy and induces a resistant phenotype to the cytotoxic effects of TNF and hyperthermia. 11165872 2001
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype BEFREE Mutations in the extracellular domain of the 55-kD tumor-necrosis factor (TNF) receptor (TNFRSF1A), a key regulator of inflammation, define a periodic-fever syndrome, TRAPS (TNF receptor-associated periodic syndrome [MIM 142680]), which is characterized by attacks of fever, sterile peritonitis, arthralgia, myalgia, skin rash, and/or conjunctivitis; some patients also develop systemic amyloidosis. 11443543 2001
CUI: C0015967
Disease: Fever
Fever
0.400 AlteredExpression phenotype BEFREE TNF-alpha gene expression was also observed in the peripheral area where the hyperthermic effect was not enough to cause cell death. 11593333 2001
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype CTD_human Indomethacin or dipyrone reduced LPS, IL-1beta, IL-6 or TNF-alpha induced fever and CRH release from rat hypothalamus. 11852909 2002
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype BEFREE Isolated, hyperthermic limb perfusion (ILP) with recombinant human tumor necrosis factor alpha and melphalan is a highly effective treatment for advanced soft tissue sarcoma (STS) and locoregional metastatic malignant melanoma. 12149303 2002
CUI: C0015967
Disease: Fever
Fever
0.400 AlteredExpression phenotype BEFREE Repeat infection stimulated a wide variety of responses; most included expression of tumor necrosis factor-alpha, a cytokine that has been associated with inflammatory and host-destructive effects (weight loss, fever, anemia). 12518848 2002
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype CTD_human The role of circulating immune complexes and biocompatibility of staphylococcal protein A immunoadsorption in mitomycin C-induced hemolytic uremic syndrome. 15384034 2004
CUI: C0015967
Disease: Fever
Fever
0.400 GeneticVariation phenotype BEFREE TNF-receptor-associated periodic syndrome (TRAPS) is a hereditary fever syndrome that results from mutations in the TNF-receptor superfamily 1A gene (TNFRSF1A). 16030167 2005
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype BEFREE Tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autoinflammatory disorder characterized by periodic attacks of fever and inflammation, due to mutations in the gene coding for the TNF type I receptor (TNFRSF1A). 16420550 2006
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype BEFREE Management with anti-TNF agent was effective with a complete remission of bouts of pain and fever. 16941196 2007
CUI: C0015967
Disease: Fever
Fever
0.400 AlteredExpression phenotype BEFREE Both the in vitro and in vivo experiments show that hyperthermia activates the mdr1 promoter in a temperature- and time-dependent manner, leading to an up to 4-fold increase in mdr1 promoter-driven TNF-alpha expression at mRNA and an up to 3-fold increase at protein level. 17237282 2007
CUI: C0015967
Disease: Fever
Fever
0.400 GeneticVariation phenotype BEFREE TNF-308A was the only allele associated with fever, poor performance status, elevated beta2-microglobulin, TNF and its p75 receptor plasma levels. 17311253 2007
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype BEFREE Under the term "periodic fevers" are gathered some monogenic diseases (familial Mediterranean fever, mevalonate kinase deficiency, and tumor necrosis factor receptor-associated syndrome) characterized by periodic or recurrent episodes of systemic inflammation causing fever often associated with rash, serositis (peritonitis, pleuritis), lymphadenopathy, arthritis, and other clinical manifestations. 18368292 2008
CUI: C0015967
Disease: Fever
Fever
0.400 Biomarker phenotype BEFREE Pro-inflammatory cytokines including TNF, IL-1alpha, IL-1beta and IL-1Ra cause systemic inflammatory reactions and numerous changes including altered cell signaling and migration, changes in cytokine production and fever. 19747989 2009