|
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.
|
22921902 |
2012 |
|
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The TNF-alpha gene promoter polymorphism G/A at position -308 has been associated with enhanced TNF-alpha secretion, as has been heart failure.
|
18450464 |
2008 |
|
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for eGFR, albuminuria, and other traditional cardiovascular risk factors, anemia (1.37, 95% CI 1.09, 1.72, <i>P</i>=0.006), insulin resistance (1.16, 95% CI 1.04, 1.28, <i>P</i>=0.006), hemoglobin A1c (1.27, 95% CI 1.14, 1.41, <i>P</i><0.001), interleukin-6 (1.15, 95% CI 1.05, 1.25, <i>P</i>=0.002), and tumor necrosis factor-α (1.10, 95% CI 1.00, 1.21, <i>P</i>=0.05) were all significantly and directly associated with incidence of heart failure.
|
28515118 |
2017 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
A polymorphism within tumor necrosis factor-α (TNF-α) gene promoter and contribution of TNF-α converting enzyme (TACE) have been reported to be associated with TNF-α production which may increase susceptibility to heart failure such as acute myocardial infarction (AMI).
|
21153921 |
2011 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Expression of innate immune response proteins, including IL-1beta, TNF, and the cytokine-inducible isoform of nitric oxide synthase (iNOS), have been documented in the hearts of humans and experimental animals with heart failure regardless of etiology, although the proximal events leading to their expression are unknown.
|
10430608 |
1999 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Circulating plasma concentrations of pro-inflammatory cytokines (e.g., tumor necrosis factor [TNF]-alpha and interleukin [IL]-6) are elevated in patients with heart failure and these cytokines have been shown to down-regulate CYP enzyme activity.
|
12411982 |
2002 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Studies have shown co-relationship between severity of heart failure and levels of the proinflammatory cytokine TNFα and one of its secondary mediators interleukin-6 (IL-6), suggesting their potential as biomarkers.
|
30259192 |
2018 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, TNF-α appears to be involved in the pathogenesis of atherosclerosis and heart failure.
|
28722106 |
2017 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-α (TNF-α) contributes to the genesis of heart failure and impairs mitochondria.
|
29613828 |
2018 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
MGD |
|
|
|
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
We studied the cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta and IL-6 and the terminal stage of the apoptotic pathway in patients with decompensating heart failure who required LVAD support and compared them with patients with less severe heart failure undergoing elective heart transplantation.
|
11568062 |
2001 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Enhanced expression and shedding of tumor necrosis factor (TNF) receptors from mononuclear leukocytes in human heart failure.
|
9799654 |
1998 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
TNF-α receptor 1 knockdown in the subfornical organ ameliorates sympathetic excitation and cardiac hemodynamics in heart failure rats.
|
28710070 |
2017 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Survey data indicated few (5/25) providers do not actively avoid TNFα inhibitors for those with HF.
|
28417241 |
2017 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
This article reviews recent clinical and experimental material that suggest that the cytokines (e.g., tumor necrosis factor alpha), much like the neurohormones, may represent another class of biologically active molecules that are responsible for the development and progression of heart failure.
|
10358791 |
1999 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
To assess the activity of the TNF-alpha system in patients with heart failure and after heart transplantation.
|
10329082 |
1999 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
So far, it has been found that inflammatory cytokines associated with the heart failure mechanism include TNF-<i>α</i>, IL-6, IL-8, IL-10, IL-1<i>α</i>, IL-1<i>β</i>, IL-2, TGF-<i>β</i>, and IFN-<i>γ</i>.
|
31275453 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inflammation is a central process in the pathophysiology of heart failure (HF), but trials targeting tumour necrosis factor (TNF)-α were largely unsuccessful.
|
31087601 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4.
|
15231041 |
2004 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Transforming growth factor-beta receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor.
|
18034274 |
2008 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
This article will review recent clinical and experimental material which suggests that tumor necrosis factor (TNF), a pro-inflammatory cytokine, may contribute to disease progression in heart failure by virtue of the direct toxic effects that this molecule exerts on the heart and circulation.
|
11309526 |
2001 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this review, we describe available data on the occurrence of adverse events associated with TNF inhibitor treatment in ankylosing spondylitis, including serious adverse events, infections, serious infections, tuberculosis, opportunistic infections, hepatitis B reactivation, malignancies, laboratory test abnormalities, autoimmune diseases, paradoxical adverse events, and heart failure.
|
30476367 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF)-alpha has been implicated in the pathophysiology of heart failure.
|
15189946 |
2004 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The protective and anti-inflammatory effects of TNFR2 may explain why TNF inhibitors failed to be effective in diseases such as heart failure or multiple sclerosis, where TNF has been strongly implicated as a driving force.
|
30856027 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tumour necrosis factor alpha (TNF alpha) is implicated in the pathophysiology of heart failure.
|
11796554 |
2002 |