|
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.
|
22921902 |
2012 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
A polymorphism within tumor necrosis factor-α (TNF-α) gene promoter and contribution of TNF-α converting enzyme (TACE) have been reported to be associated with TNF-α production which may increase susceptibility to heart failure such as acute myocardial infarction (AMI).
|
21153921 |
2011 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Expression of innate immune response proteins, including IL-1beta, TNF, and the cytokine-inducible isoform of nitric oxide synthase (iNOS), have been documented in the hearts of humans and experimental animals with heart failure regardless of etiology, although the proximal events leading to their expression are unknown.
|
10430608 |
1999 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Circulating plasma concentrations of pro-inflammatory cytokines (e.g., tumor necrosis factor [TNF]-alpha and interleukin [IL]-6) are elevated in patients with heart failure and these cytokines have been shown to down-regulate CYP enzyme activity.
|
12411982 |
2002 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the observation that failing hearts express elevated levels of TNF-alpha suggests that overexpression of this cytokine may be one of several different maladaptive mechanisms responsible for the progressive cardiac decompensation that occurs in advanced heart failure.
|
8640999 |
1996 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Studies have shown co-relationship between severity of heart failure and levels of the proinflammatory cytokine TNFα and one of its secondary mediators interleukin-6 (IL-6), suggesting their potential as biomarkers.
|
30259192 |
2018 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, TNF-α appears to be involved in the pathogenesis of atherosclerosis and heart failure.
|
28722106 |
2017 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
miRNA-130a improves cardiac function by down-regulating TNF-α expression in a rat model of heart failure.
|
30556887 |
2018 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-α (TNF-α) contributes to the genesis of heart failure and impairs mitochondria.
|
29613828 |
2018 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
MGD |
|
|
|
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
We studied the cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta and IL-6 and the terminal stage of the apoptotic pathway in patients with decompensating heart failure who required LVAD support and compared them with patients with less severe heart failure undergoing elective heart transplantation.
|
11568062 |
2001 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Enhanced expression and shedding of tumor necrosis factor (TNF) receptors from mononuclear leukocytes in human heart failure.
|
9799654 |
1998 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
TNF-α receptor 1 knockdown in the subfornical organ ameliorates sympathetic excitation and cardiac hemodynamics in heart failure rats.
|
28710070 |
2017 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
[The effects of exercise training on plasma tumor necrosis factor-alpha, blood leucocyte and its components in congestive heart failure patients].
|
12133434 |
2002 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Survey data indicated few (5/25) providers do not actively avoid TNFα inhibitors for those with HF.
|
28417241 |
2017 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
This article reviews recent clinical and experimental material that suggest that the cytokines (e.g., tumor necrosis factor alpha), much like the neurohormones, may represent another class of biologically active molecules that are responsible for the development and progression of heart failure.
|
10358791 |
1999 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Last, PNA5 treatment decreased VCID/HF-induced activation of brain microglia/macrophages and inhibited circulating tumor necrosis factor <i>α</i>, interleukin (IL)-7, and granulocyte cell-stimulating factor serum levels while increasing that of the anti-inflammatory cytokine IL-10.
|
30709867 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
To assess the activity of the TNF-alpha system in patients with heart failure and after heart transplantation.
|
10329082 |
1999 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
So far, it has been found that inflammatory cytokines associated with the heart failure mechanism include TNF-<i>α</i>, IL-6, IL-8, IL-10, IL-1<i>α</i>, IL-1<i>β</i>, IL-2, TGF-<i>β</i>, and IFN-<i>γ</i>.
|
31275453 |
2019 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The role of inflammatory signaling is discussed and TLR4 signaling, IL-1β, TNFα and IL-6 expression appears to coincide with the development of heart failure.
|
21503626 |
2011 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha.
|
9577949 |
1998 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we showed anti-inflammatory effects of liraglutide treatment, reflected in reductions in levels of TNF-α and MR-proADM, while the reduction in MR-proANP levels may represent a clinically relevant benefit with regard to heart failure.
|
28105731 |
2017 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inflammation is a central process in the pathophysiology of heart failure (HF), but trials targeting tumour necrosis factor (TNF)-α were largely unsuccessful.
|
31087601 |
2019 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4.
|
15231041 |
2004 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Transforming growth factor-beta receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor.
|
18034274 |
2008 |