|
Heart failure
|
0.600 |
Biomarker
|
disease |
MGD |
|
|
|
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the observation that failing hearts express elevated levels of TNF-alpha suggests that overexpression of this cytokine may be one of several different maladaptive mechanisms responsible for the progressive cardiac decompensation that occurs in advanced heart failure.
|
8640999 |
1996 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Enhanced expression and shedding of tumor necrosis factor (TNF) receptors from mononuclear leukocytes in human heart failure.
|
9799654 |
1998 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Cardiac failure in transgenic mice with myocardial expression of tumor necrosis factor-alpha.
|
9577949 |
1998 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Expression of innate immune response proteins, including IL-1beta, TNF, and the cytokine-inducible isoform of nitric oxide synthase (iNOS), have been documented in the hearts of humans and experimental animals with heart failure regardless of etiology, although the proximal events leading to their expression are unknown.
|
10430608 |
1999 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
This article reviews recent clinical and experimental material that suggest that the cytokines (e.g., tumor necrosis factor alpha), much like the neurohormones, may represent another class of biologically active molecules that are responsible for the development and progression of heart failure.
|
10358791 |
1999 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
To assess the activity of the TNF-alpha system in patients with heart failure and after heart transplantation.
|
10329082 |
1999 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have studied the cytokines tumor necrosis factor (TNF)-alpha and interleukin-6 (IL-6) in the myocardium and serum from donors with myocardial dysfunction (unused donors) and compared them with donors with good ventricular function (used donors) and patients with advanced heart failure (HF).
|
11082413 |
2000 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
We studied the cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta and IL-6 and the terminal stage of the apoptotic pathway in patients with decompensating heart failure who required LVAD support and compared them with patients with less severe heart failure undergoing elective heart transplantation.
|
11568062 |
2001 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
This article will review recent clinical and experimental material which suggests that tumor necrosis factor (TNF), a pro-inflammatory cytokine, may contribute to disease progression in heart failure by virtue of the direct toxic effects that this molecule exerts on the heart and circulation.
|
11309526 |
2001 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Clinical indices of heart failure were retrospectively analyzed and correlated with myocardial TNFalpha expression.
|
11789791 |
2001 |
|
Heart failure
|
0.600 |
Therapeutic
|
disease |
RGD |
Tumor necrosis factor-alpha (TNF-alpha) probably affects the pathogenesis of heart failure.
|
11668085 |
2001 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Circulating plasma concentrations of pro-inflammatory cytokines (e.g., tumor necrosis factor [TNF]-alpha and interleukin [IL]-6) are elevated in patients with heart failure and these cytokines have been shown to down-regulate CYP enzyme activity.
|
12411982 |
2002 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
[The effects of exercise training on plasma tumor necrosis factor-alpha, blood leucocyte and its components in congestive heart failure patients].
|
12133434 |
2002 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tumour necrosis factor alpha (TNF alpha) is implicated in the pathophysiology of heart failure.
|
11796554 |
2002 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4.
|
15231041 |
2004 |
|
Heart failure
|
0.600 |
Therapeutic
|
disease |
RGD |
New insights into the pathological role of TNF-alpha in early cardiac dysfunction and subsequent heart failure after infarction in rats.
|
15210453 |
2004 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF)-alpha has been implicated in the pathophysiology of heart failure.
|
15189946 |
2004 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
LHGDN |
TNFalpha in patients with congestive heart failure.
|
14685701 |
2004 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Heart failure may in fact be accentuated by a downregulation of myocardial TNF-alpha.
|
15135663 |
2004 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The higher TNFalpha gene expression in patients with compensated heart failure suggests that cytokine gene expression has an adaptive role in the early phase of LV remodelling.
|
15958363 |
2005 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increasing evidence suggests that development of heart failure involves activation of stress-response inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-6.
|
15867183 |
2005 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we show that p8, a small stress-inducible basic helix-loop-helix protein, is required for endothelin- and alpha-adrenergic agonist-induced cardiomyocyte hypertrophy and for tumor necrosis factor-stimulated induction, in cardiac fibroblasts, of matrix metalloproteases (MMPs) 9 and 13-MMPs linked to general inflammation and to adverse ventricular remodeling in heart failure.
|
17116693 |
2007 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in the pathogenesis of heart failure.
|
17337591 |
2007 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Transforming growth factor-beta receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor.
|
18034274 |
2008 |