Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Last, PNA5 treatment decreased VCID/HF-induced activation of brain microglia/macrophages and inhibited circulating tumor necrosis factor <i>α</i>, interleukin (IL)-7, and granulocyte cell-stimulating factor serum levels while increasing that of the anti-inflammatory cytokine IL-10.
|
30709867 |
2019 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
So far, it has been found that inflammatory cytokines associated with the heart failure mechanism include TNF-<i>α</i>, IL-6, IL-8, IL-10, IL-1<i>α</i>, IL-1<i>β</i>, IL-2, TGF-<i>β</i>, and IFN-<i>γ</i>.
|
31275453 |
2019 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inflammation is a central process in the pathophysiology of heart failure (HF), but trials targeting tumour necrosis factor (TNF)-α were largely unsuccessful.
|
31087601 |
2019 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this review, we describe available data on the occurrence of adverse events associated with TNF inhibitor treatment in ankylosing spondylitis, including serious adverse events, infections, serious infections, tuberculosis, opportunistic infections, hepatitis B reactivation, malignancies, laboratory test abnormalities, autoimmune diseases, paradoxical adverse events, and heart failure.
|
30476367 |
2019 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
The protective and anti-inflammatory effects of TNFR2 may explain why TNF inhibitors failed to be effective in diseases such as heart failure or multiple sclerosis, where TNF has been strongly implicated as a driving force.
|
30856027 |
2019 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
A functional analysis of T cells from patients with acute HF revealed that the CD4<sup>+</sup>CD57<sup>+</sup> T cell population exhibited a higher frequency of IFN-γ- and TNF-α- producing cells compared to the CD4<sup>+</sup>CD57<sup>-</sup> T cell population.
|
31501486 |
2019 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Adult male wild-type C57BL/6 mice, Foxp3-diphtheria toxin receptor transgenic mice, and tumor necrosis factor (TNF) α receptor-1 (TNFR1)<sup>-</sup><sup>/-</sup> mice underwent nonreperfused myocardial infarction to induce HF or sham operation.
|
30586716 |
2019 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-α (TNF-α) is a biomarker of inflammation that occurs in patients suffering from heart failure (HF).
|
30744018 |
2019 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Patients with MI and HF had reduced serum irisin, LVEF, and HDL-C and higher levels of BMI, WHR, SBP, DBP, troponin-I, creatine kinase-MB (CK-MB), TNF-α, TC, TGs, and LDL-C compared with control.
|
30958967 |
2019 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The elevated level of TNF-α in the brain and circulation in heart failure (HF) suggests an increase in the TACE-mediated ectodomain shedding process.
|
31154904 |
2019 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Studies have shown co-relationship between severity of heart failure and levels of the proinflammatory cytokine TNFα and one of its secondary mediators interleukin-6 (IL-6), suggesting their potential as biomarkers.
|
30259192 |
2018 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
miRNA-130a improves cardiac function by down-regulating TNF-α expression in a rat model of heart failure.
|
30556887 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-α (TNF-α) contributes to the genesis of heart failure and impairs mitochondria.
|
29613828 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this review, we explore the emerging role of tumor necrosis factor receptor-associated factor 6 (TRAF6)-nuclear factor kappa B (NF-κB) signaling axis in atherosclerosis, ischemic heart disease, pathologic cardiac hypertrophy or heart failure, myocarditis, and sepsis-induced cardiomyopathy.
|
29175266 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Bimodal Function of Anti-TNF Treatment: Shall We Be Concerned about Anti-TNF Treatment in Patients with Rheumatoid Arthritis and Heart Failure?
|
29895751 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
TLR2 and TLR3 expression as a biomarker for the risk of doxorubicin-induced heart failure.
|
29959987 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
RGD |
ExT reduced by 59% TNF-α level in Tr-HF group (MD -1.7; 95% CI -2.9 to -0.3) and increased IL-10 (MD 15; 95% CI 11-26) when compared with the Sed-HF group.
|
28939262 |
2018 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, TNF-α appears to be involved in the pathogenesis of atherosclerosis and heart failure.
|
28722106 |
2017 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
TNF-α receptor 1 knockdown in the subfornical organ ameliorates sympathetic excitation and cardiac hemodynamics in heart failure rats.
|
28710070 |
2017 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Survey data indicated few (5/25) providers do not actively avoid TNFα inhibitors for those with HF.
|
28417241 |
2017 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we showed anti-inflammatory effects of liraglutide treatment, reflected in reductions in levels of TNF-α and MR-proADM, while the reduction in MR-proANP levels may represent a clinically relevant benefit with regard to heart failure.
|
28105731 |
2017 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Renal sympathetic denervation improves myocardial apoptosis in rats with isoproterenol-induced heart failure by downregulation of tumor necrosis factor-α and nuclear factor-κB.
|
29104628 |
2017 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Despite these well-described observations, less is known about the mechanistic underpinnings of proinflammatory cytokines especially TNFα in pathogenesis of HF.
|
28763371 |
2017 |
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
TNF Receptor 1/2 Predict Heart Failure Risk in Type 2 Diabetes Mellitus Patients.
|
28367848 |
2017 |
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
RT-PCR showed that the mRNA expressions of TNF-α, Fas and FasL in heart failure group were significantly higher than those in normal group.
|
28925471 |
2017 |