Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
Cosegregation of the Tnfalpha locus with cardiovascular phenotypes in the F2 generation of a New Zealand genetically hypertensive and Brown Norway cross.
|
9590569 |
1998 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In conclusion, the results of linkage and association analyses suggest that in hypertensive pedigrees of French-Canadian origin, the TNF-alpha gene locus contributes to the determination of obesity and obesity-associated hypertension.
|
10904006 |
2000 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Plasma sTNF-R2 was elevated in HTs (P < 0.
|
10942422 |
2000 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The gene for this receptor (TNF-RSF1B) has, moreover, been implicated in hypertension, elevated cholesterol and insulin resistance.
|
11357933 |
2001 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
However, although they do not reach statistical significance (which may be due to the relatively restricted number of subjects included in this study), the distribution differences (in normotensives and hypertensives) observed in the cases of EGF and TNF-alpha reflect trends that could be expected from a mechanistic explanation of the pathways that underlie the patho-physiology of hypertension.
|
12009575 |
2002 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Multivariate logistic regression analysis with adjustment for age, body mass index, and the prevalence of smoking, diabetes mellitus, hypercholesterolemia, and hyperuricemia revealed that 2 polymorphisms (825C-->T in the G protein beta3 subunit gene and 190G-->A in the CC chemokine receptor 2 gene) were significantly associated with hypertension in men and that one polymorphism (-238G-->A in the tumor necrosis factor alpha gene) was significantly associated with hypertension in women.
|
12654703 |
2003 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
These findings have raised the possibility that decreased expression of adrenomedullin by tumor necrosis factor-alpha may be related to the increased risk of hypertension and other cardiovascular diseases in obese subjects.
|
15808915 |
2005 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The G-308A tumor necrosis factor (TNF) alpha gene variant has been associated with obesity, insulin resistance, and hypertension.
|
16421346 |
2005 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The G-308A promoter variant of the tumor necrosis factor-alpha gene is associated with hypertension in adolescents harboring the metabolic syndrome.
|
16202847 |
2005 |
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
RGD |
These data suggest that TNF-alpha contributes to downregulation of Cyp2c23, blood pressure regulation, and renal injury in angiotensin high-salt hypertension.
|
16415373 |
2006 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We demonstrated in rodents that stimulation of sensory neurons reduces hypertension, stress-induced gastric mucosal injury, reperfusion-induced liver injury, and endotoxin-induced shock responses by attenuating inflammatory responses such as increases in both tissue levels of tumor necrosis factor (TNF) and tissue accumulation of neutrophils.
|
16918352 |
2006 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
LHGDN |
An association is demonstrated among TNFalpha gene polymorphism, Koreans with hypertension, and iris constitution.
|
17708628 |
2007 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
After stratification according to risk factors for CAD, our analysis revealed that CAD patients with diabetes (p=0.042) and CAD patients without hypertension (p= 0.0495) displayed a higher frequency of the TNF -308 AA genotype compared with healthy controls.
|
17346438 |
2007 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In this paper, the relationship between iris constitution and TNFalpha gene polymorphism in those with hypertension is investigated.
|
17708628 |
2007 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These data support the hypothesis that endogenous TNF-alpha is an important stimulus for ET-1 in response to placental ischemia and is important in mediating endothelial cell activation and hypertension during pregnancy.
|
18981324 |
2008 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
In conclusion, our findings show that plasma tHcy is a determinant of TNF-alpha in hypertension and that obesity or a history of vascular events aggravates inflammation in patients with hypertension.
|
18093792 |
2008 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
CTD_human |
Serum neopterin, nitric oxide, inducible nitric oxide synthase and tumor necrosis factor-alpha levels in patients with ischemic heart disease.
|
18605955 |
2008 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our results suggest that APOB, WRN, ACAT2, APOE, PPARG, TNF and PTGS1 are susceptibility loci for CKD among Japanese individuals with hypertension.
|
19282863 |
2009 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We examined the association of insulin resistance and enhanced TNF pathway with severe hypertension and the association of a microsatellite polymorphism of the TNFR2 gene with severe hypertension.
|
19557004 |
2009 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Infusion of Ang II increased blood pressure (p < 0.001) but decreased vascular relaxation in response to acetylcholine, endothelial nitric oxide synthase (eNOS) and phosphorylated eNOS (peNOS) levels, and renal and plasma levels of adiponectin (p < 0.05); in contrast, plasma tumor necrosis factor-α and monocyte chemoattractant protein-1 levels increased.
|
20836698 |
2011 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Inhibition of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension.
|
23071256 |
2012 |
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
TNF-α neutralization reduced hypertension, albuminuria and renal inflammation and fibrosis, which were coupled to a reduction in renal NF-ĸB activation, inflammatory markers expression, TGF-β1 and ET-1 production, and an increase in NO release.
|
22813949 |
2012 |
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Our results suggest that the G-308A polymorphism of the TNF-α gene may be independently associated with hypertension, leptin level and hypercholesterolemia leading to metabolic syndrome independent of Insulin resistance and hyperglycemia.
|
21616679 |
2012 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Our study suggests that epigenetic mechanisms and release of tumor necrosis factor-α by infiltrating neutrophils could contribute to the increased expression of thromboxane synthase in maternal systemic blood vessels, contributing to the hypertension and coagulation abnormalities associated with preeclampsia.
|
22493072 |
2012 |
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
TNF-α induced the expression of 18 cytokines/chemokines and five tissue remodeling genes involved in severe, corticosteroid-insensitive asthma, chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and/or pulmonary hypertension.
|
23590298 |
2013 |