Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus we present evidence that in colorectal cancer only a small proportion of tumor-infiltrating macrophages produces TNF, indicating that the microenvironment of the tumor provides adequate, yet suboptimal, conditions for macrophage activation.
|
2662193 |
1989 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, we also examined paired normal and tumor DNA from the colorectal cancer group for microsatellite alterations at the TNF alpha locus, including allelic loss of heterozygosity and microsatellite instability.
|
8548754 |
1996 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These data provide evidence for the involvement of the TNF locus in the pathogenetic etiology of colorectal cancer.
|
9243755 |
1997 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We examined the relationship between the NcoI RFLP of tumor necrosis factor beta (TNFB) and alpha (TNFA) genes and the risk of colorectal cancer.
|
9638659 |
1998 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Endogenous TNF inducibility and prognosis of colorectal cancer.
|
9891459 |
1999 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A secreted member of the TNF receptor superfamily, the decoy receptor 3 (DcR3), was reported to be amplified in colorectal cancer as a negative regulator of Fas-mediated apoptosis.
|
12397645 |
2002 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The HT29 adenocarcinoma is a common model of epithelial cell differentiation and colorectal cancer and its death is an oft-analyzed response to TNF family receptor signaling.
|
12478469 |
2002 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-related apoptosis-inducing ligand gene on human colorectal cancer cell line HT29.
|
12717839 |
2003 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have studied the association between single nucleotide polymorphisms in the interleukin (IL)-6 (-174 G>C), IL8 (-251T>A), tumor necrosis factor alpha (-308G>A), and PPARG (Pro12Ala) genes and the risk of CRC in a group of 377 cases and 326 controls from Barcelona, Spain.
|
12839942 |
2003 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied the association of SNPs in the IL-6 (-174G>C), IL-8 (-251T>A), TNFalpha (-308G>A), ICAM-1 (R241G and K469E), and PPARgamma (Pro12Ala) genes and the risk of CRC.
|
16937502 |
2006 |
Colorectal Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that TNFalpha-dependent induction of MMP-9 gene expression is tightly regulated by oscillatory/cumulative activation of NFkappaB and that 5-Fu stimulates NFkappaB and RKO CRC cell survival through induction of IKK activity.
|
17186550 |
2007 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Because UC patients are at increased risk for developing colorectal cancer (CRC), we investigated if there was an association between SNPs in the promoter of the TNF-alpha gene and UC-CRC.
|
18289203 |
2008 |
Colorectal Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
TIMP-1 expression in human colorectal cancer is associated with TGF-B1, LOXL2, INHBA1, TNF-AIP6 and TIMP-2 transcript profiles.
|
19383344 |
2008 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-α is associated with positive lymph node status in patients with recurrence of colorectal cancer--indications for anti-TNF-α agents in cancer treatment.
|
20978325 |
2010 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Pooled odd ratios (ORs) and 95% confidence intervals (95% CIs) were calculated on the basis of data from 14, 18, and 7 studies from a total of 27 studies for the associations between the polymorphism of TNF-α-308 G>A and ulcerative colitis, Crohn's disease (CD) and CRC.
|
21248737 |
2011 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-α is associated with positive lymph node status in patients with recurrence of colorectal cancer-indications for anti-TNF-α agents in cancer treatment.
|
21573932 |
2011 |
Colorectal Carcinoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of LBP (rs1739654, rs2232596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study.
|
21633598 |
2011 |
Colorectal Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It has been hypothesized that the VDR-mediated signaling antagonizing TNF-α and IL-6 receptor-activated pro-inflammatory and proliferative intracellular pathways, may prevent development of IBD and colitis-associated colorectal cancer.
|
21801808 |
2011 |
Colorectal Carcinoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
PRKCDBP is a proapoptotic tumor suppressor which is commonly altered in colorectal cancer by promoter hypermethylation, and its gene transcription is directly activated by NF-κB in response to TNFα.
|
21980136 |
2011 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To evaluate the effect of mitochondrial tumor necrosis factor receptor-associated protein-1 (TRAP-1) on the lymph node metastasis (LNM) in Chinese colorectal cancer (CRC) patients, and develop potential LNM-associated biomarkers for CRC using quantitative real-time polymerase chain reaction (RT-PCR) analysis.
|
23139614 |
2012 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we showed that TNFα induces EMT in human HCT116 cells and thereby promotes colorectal cancer (CRC) invasion and metastasis.
|
23431386 |
2013 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
CTD_human |
In this study, we showed that TNFα induces EMT in human HCT116 cells and thereby promotes colorectal cancer (CRC) invasion and metastasis.
|
23431386 |
2013 |
Colorectal Carcinoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Finally, both TNFα-receptors were shown to be under-expressed in the inflamed colon mucosa and colorectal cancer tissue compared to healthy colon mucosa.
|
24379584 |
2013 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
TNF-a 238A was not associated with colorectal cancer risk under homozygote or heterozygote comparisons.
|
24404201 |
2014 |
Colorectal Carcinoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The low expression of IL17A caused by the Smad7 expression in tumor-infiltrating CD4(+) T cells enabled the TNF-α-mediated killing of cancer cells both in vitro and in vivo, thus indicating that the Smad7-mediated plastic effect on T-cell phenotype induces protection against colorectal cancer.
|
24480808 |
2014 |