TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE L19-TNFα/L19-IL2 combination therapy eradicated tumors in J558L myeloma BALB/c mice likely via TNFα-induced tumor necrosis and L19-TNFα/L19-IL2-mediated local cellular immune reactions. 29327244 2018
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 GeneticVariation phenotype BEFREE Several rheumatoid arthritis (RA) susceptibility variants map close to genes involved in the tumor necrosis factor (TNF) signaling pathway, prompting the investigation of RA susceptibility variants in studies of predictors of response to TNF blockade. 21952740 2012
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE Tumour necrosis factor (TNF) signalling is mediated via two receptors, TNF-receptor 1 (TNFR1) and TNF-receptor 2 (TNFR2), which work antithetically to balance CNS immune responses involved in autoimmune diseases such as multiple sclerosis. 30206422 2018
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE In addition, there were significant differences in interleukin (IL)-6 and tumor necrosis (TNF)-α concentrations at 24 h after hepatectomy between the two groups, and mean arterial pressure, heart rate, and the bispectral index were also significantly lower in D group than in C group (p < .05). 31669050 2020
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE TNF-α inhibition resulted in suppression of IL-6 and IL-8 in parallel with clinical improvement in all anti-TNF-treated subjects, but was also associated with elevated TNF-α and IL-17 in etanercept-treated subjects. 26934060 2016
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE Additionally, the majority of DEGs were mainly enriched in NF-kappa β (NF-kβ) signaling pathway and tumor necrosis factor (TNF) signaling pathway. 31277141 2019
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE Analysis of tumor necrosis factor (TNF) signaling pathway which regulates the transcription factor Nuclear Factor κB (NF-κB) using this method identifies two types of incorrect cell decisions called false alarm and miss. 28379950 2017
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE LPS, interleukin-1 (IL-1), and to a lesser extent tumor necrosis factor (TNF) significantly decreased MTP mRNA levels in hamster liver.These effects required several hours. 9643353 1998
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis indicated that these proteins mainly were involved in the process of cytokine-cytokine receptor interaction, transforming growth factor-β (TGF-β) signaling pathway, pathways in cancer, tumor necrosis factor (TNF) signaling pathway, and mitogen-activated protein kinase (MAPK) signaling pathway. 29344174 2017
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 GeneticVariation phenotype BEFREE After lenalidomide treatment, genes involved in the tumor necrosis factor (TNF) signaling pathway that were upregulated in the patients before treatment decreased to the healthy control baseline expression level. 22608605 2012
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE Signaling pathway analysis revealed that these DEGs were mainly involved in apoptosis, hypoxia‑inducible factor (HIF) 1a pathway, innate immune system, tumor necrosis factor (TNF) signaling pathway, cytokine‑cytokine receptor interaction, and other signal transduction pathways. 28944843 2017
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE 3xTg-AD mice had an increased pro-inflammatory response characterised by the production of pro-inflammatory mediators such as tumour necrosis TNF-α, IL-6, CCL5 and CXCL-1, as well as an increase in immune cell infiltration to the sites of infection. 28284226 2017
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that these DEGs were mainly associated with metabolic pathways, the peroxisome proliferator-activated receptor (PPAR) signaling pathway, regulation of lipolysis in adipocytes, the tumor necrosis factor (TNF) signaling pathway, and the FoxO signaling pathway. 30424473 2018
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 AlteredExpression phenotype BEFREE This study used an in vitro model to explore the expression and function of tumor necrosis factor (TNF) signaling pathway in bupivacaine-induced apoptotic injury in spinal cord dorsal root ganglia (DRG). 29802833 2018
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE PubMed literature searches were conducted using combinations of search terms including ankylosing spondylitis, spondyloarthropathy, spondyloarthritis, switch/switching, drug survival, and TNF/tumor necrosis factor to identify published articles with data on outcomes related to switching biologic therapies in patients with axSpA. 28551170 2017
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE These effects can be explained by the diverse cellular responses TNF can initiate through distinct signal transduction pathways, opening the way for more selective targeting of TNF signalling in cancer therapy. 23460481 2013
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 PosttranslationalModification phenotype BEFREE Results showed that both PR and PS nanofibers have the ability to induce chondrogenesis of MSCs and accelerate the regeneration of injured cartilage surface, probably via the suppression of Tumor necrosis factor (TNF) signaling pathway as evidenced by microarray profiles. 30890231 2019
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE Moreover, reciprocal bone marrow transplantation experiments using TNF receptor-deficient mice revealed that TNF signals are equally pathogenic when directed independently to either bone marrow-derived or tissue stroma cell targets. 12486099 2002
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE In particular, pro-apoptotic tumor necrosis factor (TNF) signals are blocked by proteins that are induced by NF-kappaB such as TNFR-associated factor 1 (TRAF1). 10692572 2000
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE Consecutive CD patients with intestinal strictures that initiated treatment with anti-tumor necrosis alpha (anti-TNF) between June 2012 and April 2017 with MRE adjacent to treatment onset were retrospectively collected. 29779158 2018
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE Pathway analysis suggests that tumor necrosis factor (TNF) signaling pathway, NOD-like receptor pathway, and cytokine-cytokine receptor interaction may be involved in ALI. 30979832 2019
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 AlteredExpression phenotype BEFREE These humoral factors can generally be divided into those which, like RANKL, are tumour necrosis family (TNF) superfamily members and those which are not; the former include TNFα lymphotoxin exhibiting inducible expression and competing with herpes simplex virus glycoprotein D for herpesvirus entry mediator, a receptor expressed by T lymphocytes (LIGHT), a proliferation inducing ligand (APRIL) and B cell activating factor (BAFF); the latter include transforming growth factor beta (TGF-β), interleukin-6 (IL-6), IL-8, IL-11, nerve growth factor (NGF), insulin-like growth factor-I (IGF-I) and IGF-II. 26578261 2016
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE The tumor necrosis factor (TNF) signaling pathway is a classical immune system pathway that plays a key role in regulating cell survival and apoptosis. 25912078 2015
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE Tumor necrosis factor (TNF) signaling is required for inflammatory nociceptive (pain) sensitization in Drosophila and vertebrates. 28492538 2017
CUI: C0333516
Disease: Tumor necrosis
Tumor necrosis
0.100 Biomarker phenotype BEFREE DNA chip analysis revealed upregulation of TNF-alpha mRNA and a number of molecules involved in TNF-signaling such as TRAF-6, caspases-10, and -7 in depsipeptide-treated HL-60 cells, which prompted us to examine the involvement of the TNF/TNF receptor system in the anti-leukemic effects of the drug. 15515013 2005