|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of ICAM-1 on the surface of human umbilical vein endothelial cells and a human lung carcinoma cell line (A549) was increased by interleukin-1 beta, tumor necrosis factor alpha, and interferon gamma in a concentration-dependent manner.
|
1680858 |
1991 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data suggest that TNF can induce antitumor defenses to suppress in vivo human tumor cell growth and provide a rationale for transferring the human TNF cDNA directly to malignant cells for the therapy of human lung cancer.
|
8086165 |
1994 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thirteen human lung cancer cell lines, 7 representing small cell lung cancer (SCLC) and 6 different types of non-SCLC, were tested for sensitivity to tumour necrosis factor alpha (TNF-alpha) and interferon alpha and gamma (IFN-alpha and gamma) using an automated fluorometric microculture cytotoxicity assay (FMCA).
|
8695164 |
1996 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Normal peripheral blood mononuclear cells (PBMC) were co-cultured with a human lung cancer cell line (LC89) transduced with the interleukin-2 (IL-2), IL-7, granulocyte-macrophage colony-stimulating factor (GM-CSF), and tumor necrosis factor-alpha (TNF-alpha) genes to evaluate the capacity of the engineered cells to: allow survival of CD3+ and CD56+ cells, generate cytotoxic effectors with HLA class I restricted and unrestricted antitumor activity, and interfere in the molecular organization of the CD3/T-cell receptor associated signal transduction machinery.
|
8978294 |
1997 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effect of gene transfer of tumor necrosis factor receptors into human lung carcinoma cell line.
|
9685865 |
1998 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Probing nuclear extracts of lung cancer cells with NF-kappaB-sequence-specific oligonucleotides indicated that there was a minimal amount of NF-kappaB in the nucleus at baseline and an expected and dramatic increase in nuclear NF-kappaB following exposure of cells to TNF-alpha.
|
10423407 |
1999 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumour necrosis factor alpha (TNF-alpha) and transforming growth factor beta (TGF-beta) have emerged as two of the many host-derived mediators that seem to interfere with both antiproliferative and tumorigenic effects in malignant tumours including lung cancer.
|
10945495 |
2000 |
|
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present study examined whether tumor necrosis factor (TNF), which mediates many of the cellular responses associated with inflammatory reactions or cancer progression, can affect the KAI1/CD82 expression in lung cancer cells and, if so, whether nuclear factor (NF)-kappaB, a key molecule in TNF-mediated gene expression, is involved in the mechanism of KAI1/CD82 induction.
|
11212267 |
2001 |
|
Carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Parallel changes in antioxidant activities, protein, and mRNA expression were noted in A549 lung carcinoma cell lines exposed to cytokines (tumor necrosis factor-alpha, interleukin 1beta, and IFN-gamma).
|
11731445 |
2001 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that concurrent inhibition of Rac1 and IKK pathways sensitizes lung cancer cells to TNFalpha-induced apoptosis.
|
11773980 |
2001 |
|
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One tobacco tar-resistant S. aureus strain (Sa-TA10) induced expression of the TNF-alpha gene in both Bhas 42 cells (v-Ha-ras transfected BALB/3T3 cells) and human lung cancer cell line H226B, while one tobacco tar-resistant S. warneri (Sw-TA75) did not induce it significantly.
|
15014984 |
2004 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this review, we concentrate on the current progress in the understanding of TNF-alpha-mediated apoptosis for lung carcinoma.
|
15084385 |
2004 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human recombinant tumor necrosis factor (TNF)-alpha and IL-1alpha could induce IL-8 expression in lung cancer cells in a dose-dependent manner.
|
15746434 |
2005 |
|
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Preexisting cardiovascular disease (p < 0.001), primary lung cancer (p = 0.009), extent of lung resection (p = 0.042), interleukin 6 genotype (p = 0.017), and tumor necrosis factor genotype (p = 0.005) were significantly associated with complications.
|
15854959 |
2005 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the mechanisms by which airway inflammatory agents mediate the expression of sialyl-Lewis x epitopes and MUC5AC mucin, we examined the effects of tumor necrosis factor (TNF)-alpha and epidermal growth factor (EGF) in the human lung carcinoma cell line, NCI-H292.
|
15864435 |
2005 |
|
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant association between the 308 G/A and 238 G/A polymorphisms in the promoter region of TNF-alpha and the susceptibility to lung cancer was demonstrated.
|
16476505 |
2006 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previous work has shown that celecoxib induces death receptor 5 expression, resulting in induction of apoptosis and enhancement of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in human lung cancer cells.
|
17145853 |
2006 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the undetermined effect of concurrent blockage of these two survival pathways on TNF-induced cytotoxicity in lung cancer cells.
|
17316570 |
2007 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2.
|
18794145 |
2008 |
|
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To our knowledge, this is the first study implicating decreased frequency of TNF-alpha-308 1/2 gene variant in patients with COPD and LC.
|
19469656 |
2009 |
|
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study investigated whether the TNF-alpha-308 and TNF-alpha-238 polymorphisms are associated with risk and/or severity of disease in Croatian lung cancer patients.
|
19564826 |
2009 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Adenoviral vector-mediated transfer of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can be a powerful approach to lung cancer therapy.
|
20068366 |
2009 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
4EGI-1, as a single agent, inhibited the growth and induced apoptosis of human lung cancer cells.When combined with the death ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), enhanced apoptosis-induced activity was observed.
|
20360945 |
2010 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
We show here that the TG2 inhibitor KCC009 reversed resistance to tumor necrosis factor-related apoptosis-inducing factor (TRAIL) in lung cancer cells.
|
20450916 |
2010 |
|
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
The authors stably transfected human lung carcinoma cell lines with the FucT-III gene and exposed them to TNF-α to investigate its role in regulation of sLeX expression and selectin-binding ability using semiquantitative real-time polymerase chain reaction and flow cytometry.
|
21437888 |
2011 |