TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE 12 wk of supplementation with resistant starch reduced the inflammatory marker TNF-α and heart rate, but it did not significantly improve glycemic control and other cardiovascular disease risk factors, in adults with prediabetes. 30010698 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Tumor necrosis factor-alpha (TNF-alpha) has been implicated in cardiovascular disease. 11744409 2001
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Tumor necrosis factor alpha (TNF-alpha) is a primary pro-inflammatory cytokines and has been implicated in cardiovascular disease pathogenesis. 18814905 2009
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 GeneticVariation group BEFREE TNFA -308 (rs1800629) polymorphism is associated with a higher risk of cardiovascular disease in patients with rheumatoid arthritis. 21420089 2011
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Tumor necrosis factor-alpha (TNF-α) is a pleiotropic proinflammatory cytokine and contributes to many kinds of cardiovascular diseases via its receptors (TNFR1/TNFR2). 22088456 2011
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE TNF-like weak inducer of apoptosis (TWEAK) recently emerged as a new biomarker for the diagnosis and prognosis of cardiovascular diseases. 27441657 2016
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Tumour necrosis factor-α and risk of cardiovascular disease among overfat Indonesian adolescents. 28625037 2017
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE TNF-α is the major inducer of endothelial cell death in cardiovascular diseases. 29069811 2017
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Tumor necrosis factor receptor-associated factor 6 as a nuclear factor kappa B-modulating therapeutic target in cardiovascular diseases: at the heart of it all. 29175266 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Tumor necrosis factor α (TNF-α) is a proinflammatory cytokine with manifold consequences for mammalian pathophysiology, including cardiovascular disease. 29617535 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Tumor necrosis factor alpha (TNF-α) is a cytokine with significance in early diagnosis of cardiovascular diseases, obesity and insulin resistance. 29959484 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Tumor necrosis factor-α (TNFα) is a proinflammatory cytokine that is closely linked to the development of cardiovascular disease. 30925081 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 AlteredExpression group BEFREE TNFα reached even 7-fold higher level in athletes and was highly correlated with CVD risk factor such as TG, lipoproteins LDL and HDL as well as CRP. 31220998 2020
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE A set of inflammation-related biomarkers was used as outcome: a pro/anti-inflammatory interleukins ratio, TGFβ-1, C-reactive protein, TNF-α, 3 cell adhesion molecules, and 3 types of immune cells; gamma-glutamyltransferase (GGT) and homocysteine were used as cardiovascular disease risk biomarkers, and alanine transaminase (ALT) as liver dysfunction biomarker. 29948222 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 GeneticVariation group BEFREE Additionally, we observed associations between certain bacterial populations and CVD risk factors including plasma TNF-α, plasma lipids and BMI/waist circumference. 26757793 2016
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Adipokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and resistin are pro-inflammatory, and exacerbate various metabolic and cardiovascular diseases. 28603178 2017
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group LHGDN Although a large number of pro- and anti-inflammatory cytokines are of importance, available data suggest that the anti-inflammatory cytokine interleukin (IL)-10 and the mainly proinflammatory cytokines IL-6 and tumor necrosis factor-alpha (TNF-alpha) may play important roles in the development of Th imbalance, CVD and wasting in the uremic milieu. 15780075 2005
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Among the numerous molecules that are being studied for their potential utility as biomarkers of cardiovascular diseases, much interest has been shown in the superfamily of tumor necrosis factor (TNF) receptors. 28867452 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Ample evidence supports a role for tumour necrosis factor alpha (TNFalpha) in the development of type 2 diabetes and cardiovascular disease. 12058258 2002
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 AlteredExpression group BEFREE ANDRO significantly decreased caveolin-1 and phosphodiesterase δ3 expression, lipopolysaccharide-induced IL-6 and TNF-α levels and expression of several chemokine genes, which are associated with reducing inflammation response and decreasing calcium release without affecting normal endothelia cell function, suggesting that ANDRO may be a potential candidate to treat cardiovascular diseases with less toxicity. 29112590 2017
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Anti-TNF therapy is thought to reduce clinical cardiovascular disease risk and improve vascular function in RA patients. 23295110 2013
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Awareness of the role of inflammation in CVD in patients with chronic inflammatory diseases and the potential for anti-inflammatory therapy, e.g., with tumor necrosis factor-α inhibitors, to also reduce atherosclerotic CVD has evolved into guideline- based recommendations. 29318966 2018
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Biologic inhibitors of tumor necrosis factor-α may be beneficial in preventing cardiovascular disease because tumor necrosis factor-α promotes the initiation and progression of atherosclerosis. 31208307 2019
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Circulating TNF receptors predict cardiovascular disease in patients with chronic kidney disease. 28489742 2017
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases
0.100 Biomarker group BEFREE Circulating nuclear factor-kappaB (NF-kappaB)-dependent genes, particularly tumor necrosis factor-alpha (TNF-alpha), are elevated in obstructive sleep apnea syndrome (OSAS) and likely contribute to cardiovascular disease. 16840748 2006