|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to identify several specific reliable metabolites for predicting the response of RA patients to TNF-α inhibitors (TNFi) and abatacept (ABT), using capillary electrophoresis-time-of-flight mass spectrometry (CE-TOFMS).
|
31143951 |
2019 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The human tumour necrosis factor (TNF) transgenic (hTNFtg) mouse model of RA was used to analyse the time course of pannus attachment to the cartilage and cartilage destruction, respectively, and crossed hTNFtg mice with interleukin (IL)-1(-/-) animals were used to investigate the role of IL-1 on these TNF-induced mechanisms in vivo.
|
22258493 |
2012 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Elevated TNF-α expression has been found to be associated with the development of diabetes, septic shock, tumorigenesis, cardiovascular diseases, rheumatoid arthritis and inflammatory bowel disease.
|
22650374 |
2012 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the differential pattern of distribution of TNF microsatellite alleles in an Indian population and its association with RA.
|
16099338 |
2005 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
TNF-α mRNA levels showed a clear 24-h rhythm with a peak at 22 HALO and a trough at 18 HALO after RA had developed.
|
21452922 |
2011 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The TNF-transgenic (TNF-Tg) murine model of RA develops both inflammatory arthritis and an ILD that mimics a cellular nonspecific interstitial pneumonia pattern dominated by an interstitial accumulation of inflammatory cells with minimal-to-absent fibrosis.
|
31659014 |
2019 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated A(2A)AR density and functionality in RA progression by using a longitudinal study in RA patients before and after methotrexate (MTX), anti-TNFα agents or rituximab treatments.
|
23326596 |
2013 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the synoviocyte response to TNFalpha stimulation forms the basis of development of various aspects of the pathophysiology of rheumatoid arthritis.
|
12062421 |
2002 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the association between rheumatoid factor (RF) and anti-citrullinated protein autoantibody (ACPA) status and the discontinuation of tumor necrosis factor inhibitors (TNFi) therapy due to insufficient response in bio-naïve rheumatoid arthritis (RA) patients.
|
31179526 |
2019 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Inflammatory cytokines like TNF play a central role in autoimmune disorders such as rheumatoid arthritis.
|
21471444 |
2011 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We aimed to test whether polymorphisms in the etanercept target genes TNFA and LTA are associated with clinical responses to etanercept therapy in RA patients.
|
15695296 |
2005 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
MiRNA-126 expression inhibits IL-23R mediated TNF-α or IFN-γ production in fibroblast-like synoviocytes in a mice model of collagen-induced rheumatoid arthritis.
|
30167920 |
2018 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Expression of monocyte chemotactic and activating factor in rheumatoid arthritis. Regulation of its production in synovial cells by interleukin-1 and tumor necrosis factor.
|
8507217 |
1993 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor alpha (TNFα) and its type 1 receptor (TNFR1) are implicated in several autoimmune diseases, including rheumatoid arthritis, and are associated with complications at the cardiovascular level.
|
30897335 |
2019 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Salicin significantly reduced cell viability (82.03 ± 7.06, P < 0.01), cytokines (47.70 ± 1.48 ng/L for TNF-α, 30.03 ± 3.49 ng/L for IL-6) ( P < 0.01), and matrix metalloproteinases-1/-3 expression ( P < 0.01) in IL-1β-induced RA-FLSs and inhibited ROS generation and p65 phosphorylation ( P < 0.01) as compared with IL-1β-induced treatment.
|
29852739 |
2018 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In contrast, RA FLS were particularly sensitive to the synergistic increase of Shn3 with TNF-α and IL-17A.
|
27072520 |
2016 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We measured serum levels of interleukin 6 (IL-6), IL-8, and tumor necrosis factor (TNF-alpha) by immunochemiluminescence method and serum IL-18 levels by ELISA in 50 patients with active untreated AOSD, 20 patients with active rheumatoid arthritis (RA), and 20 healthy controls.
|
15517632 |
2004 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to compare the clinical outcome of patients with rheumatoid arthritis seen in routine clinical practice treated with either TNF inhibitors or abatacept.
|
29614335 |
2018 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Pyk2 and Src were phosphorylated more on RA versus OA and ND lining cells and MPhis. pPyk2 was expressed on RA ST fibrobasts but not in MPhis at baseline, however it was upregulated upon TNFalpha or IL1beta activation in both cell types. pSrc was expressed in RA ST fibroblasts and MPhis at baseline and was further increased by TNFalpha or IL1beta stimulation. pPaxillin and pPLCgamma were upregulated in RA versus OA and ND lining cells and sublining MPhis.
|
17963503 |
2007 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Overexpression of Krüppel-like factor 4 in RA fibroblast-like synoviocytes robustly induced interleukin-6 production in the presence or absence of tumor necrosis factor-α.
|
27413250 |
2016 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
In the present study, we isolated 4-(hydroxymethyl)catechol (4-HMC) from these fungal species, and evaluated its anti-RA effects using a murine collagen-induced arthritis model and tumor necrosis factor-α-stimulated human RA synovial fibroblasts.
|
30079020 |
2018 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
We have shown, in vitro, that celastrol inhibits both IL-1β and TNF, which play an important role in RA, and, in vivo, that celastrol has significant anti-inflammatory properties.
|
26658436 |
2015 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Median time to low disease activity is shorter in tocilizumab combination therapy with csDMARDs as compared to tocilizumab monotherapy in patients with active rheumatoid arthritis and inadequate responses to csDMARDs and/or TNF inhibitors: sub-analysis of the Swiss and Austrian patients from the ACT-SURE study.
|
28776300 |
2017 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We retrospectively enrolled patients with RA who were treated with TNF inhibitors at a university hospital between December 2000 and November 2011.
|
28288508 |
2018 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The TNF-α level in AS was significantly lower than that in RA (p = 0.016).
|
31830775 |
2020 |