Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results suggest a potential protective role for HSP70 in both VaD and AD, whereas TNF-alpha may act as a risk factor only for VaD, and not for AD.
|
15832029 |
2005 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The TNF-alpha -863 A allele was associated with reduced odds of developing AD, and the test for trend suggested that having 2 copies of the A allele further reduces the risk (odds ratios [C/C, reference], 0.66 for C/A and 0.58 for A/A; P = .04).
|
16908746 |
2006 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
LHGDN |
In conclusion, our data support previous suggestions that, at least in Caucasians, the TNF gene is a disease modifier gene in patients in which AD is rising, bringing to light the importance of genetic variation at the pro-inflammatory components in the progression of AD.
|
16516271 |
2006 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our data support previous suggestions that, at least in Caucasians, the TNF gene is a disease modifier gene in patients in which AD is rising, bringing to light the importance of genetic variation at the pro-inflammatory components in the progression of AD.
|
16516271 |
2006 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The TNF-alpha -863 A allele was associated with reduced odds of developing AD, and the test for trend suggested that having 2 copies of the A allele further reduces the risk (odds ratios [C/C, reference], 0.66 for C/A and 0.58 for A/A; P = .04).
|
16908746 |
2006 |
Alzheimer's Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In a transgenic mouse model of AD in which amyloid precursor protein and presenilin-1 harboring familial AD mutations are overexpressed in specific regions of the brain, elevated activation and expression of MK2 correlated with beta-amyloid deposition, microglial activation, and up-regulation of tumor necrosis factor alpha, macrophage inflammatory protein 1alpha, and KC gene expression in the same brain regions.
|
16774924 |
2006 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have shown that in AD the cerebral microcirculation is a rich source of cytokines and chemokines including interleukins (IL) 1beta, IL-6, IL-8, tumor necrosis factor-alpha, and monocyte chemoattractant protein-1.
|
17656823 |
2007 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The levels of pro-inflammatory cytokines, such as tumour necrosis factor-alpha (TNF-alpha), are increased in the brain in Alzheimer's disease (AD).
|
17267158 |
2007 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition to identifying the epsilon4 allele of APOE and related effects, we pinpointed over a dozen potential Alzheimer disease susceptibility genes (ACE, CHRNB2, CST3, ESR1, GAPDHS, IDE, MTHFR, NCSTN, PRNP, PSEN1, TF, TFAM and TNF) with statistically significant allelic summary odds ratios (ranging from 1.11-1.38 for risk alleles and 0.92-0.67 for protective alleles).
|
17192785 |
2007 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database.
|
17192785 |
2007 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Several studies have suggested the G-308A promoter polymorphism in one of the proinflammatory cytokine genes tumor necrosis factor-alpha (TNF-alpha) encoding TNF-alpha may be associated with AD pathogenesis.
|
18396294 |
2008 |
Alzheimer's Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the current study TNFA and BAT1 promoter polymorphisms were analysed in AD and control cases and BAT1 mRNA levels were investigated in brain tissue from AD and control cases.
|
18715507 |
2008 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, the present investigation does not support the proposal that common nucleotide variations in the TNF-alpha gene can influence the development of AD at least in Italian population.
|
18834925 |
2008 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
In the current study TNFA and BAT1 promoter polymorphisms were analysed in AD and control cases and BAT1 mRNA levels were investigated in brain tissue from AD and control cases.
|
18715507 |
2008 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1beta, IL-10 and IL-17 in the brains of TLR4 wild-type AD mice were significantly higher than those in TLR4 wild-type non-transgenic littermates.
|
18510752 |
2008 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Results presented here suggest that chronic neuronal TNF-alpha expression promotes inflammation and, ultimately, neuronal cell death in this AD mouse model, advocating the development of TNF-alpha-specific agents to subvert AD.
|
18974297 |
2008 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
LHGDN |
Moreover, our study revealed a trend to increase in TNF alfa and IL-10 values in AD.
|
18283248 |
2008 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The combined effects of TNFalpha-308, IL-6 -174 and IL-10 -1082 variant alleles may be more decisive to induce functional differences and modify the risk for AD.
|
19744138 |
2009 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
And the elevation of TNF-alpha was thought to be associated with the occurrence of AD in China.
|
18992723 |
2009 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In our experience, the -308(G/A) single nucleotide polymorphism (SNP) in the TNF-alpha gene is associated with earlier age at onset in patients affected by Alzheimer's disease (AD).
|
19836613 |
2009 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Levels of tumor necrosis factor-alpha (TNF-alpha) are increased in the brain in Alzheimer's disease (AD).
|
18069092 |
2009 |
Alzheimer's Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Seventeen studies that investigated the association between 5 TNF-alpha polymorphisms (-850, -308, -863, -238, and -1031) and AD were retrieved and analyzed.
|
19445962 |
2009 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Perispinal administration of etanercept, a potent anti-TNF fusion protein, produced sustained clinical improvement in a 6-month, open-label pilot study in patients with AD ranging from mild to severe.
|
19689163 |
2009 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the present study, we determined the significance of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in Alzheimer's disease (AD).
|
19294332 |
2009 |
Alzheimer's Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Production capacity of pro-inflammatory cytokines in offspring with a parental history of AD was also different, with higher levels of IL-1beta (interleukin 1beta) (P < .001), IL-1beta to IL-1ra ratio (P < .001), tumor necrosis factor alpha (P = .008), IL-6 (P = .04), and interferon gamma (P = .01).
|
19884614 |
2009 |