|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results from association study indicated that trauma patients carrying the TNF-α/-308/A allele were more likely complicated with sepsis.
|
20805766 |
2011 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, in this pilot study the biallelic Ncol polymorphism within the TNF locus was not a prognostic marker for disease progression in high-risk NICU-admitted term and preterm infants with culture-proven sepsis.
|
10782394 |
2000 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that the -308G/A gene polymorphism in the TNF-α gene may contribute to risk of sepsis and septic shock, but not risk of mortality.
|
29212277 |
2017 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association of TNF-α-308 G/A polymorphism with sepsis remains controversial.
|
24944154 |
2014 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, we investigated the possible association between 12 polymorphisms located in the interleukin-6 (IL6), IL10, TLR-2, Toll-like receptor-4 (TLR-4), tumor necrosis factor-α and tumor necrosis factor-β (lymphotoxin α--LTA) genes and sepsis.
|
20835611 |
2010 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor alpha -- 308 polymorphism associated with increased sepsis mortality in ventilated very low birth weight infants.
|
15131465 |
2004 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inhibition of the cytokine tumor necrosis factor alpha (TNFα), originally considered as a mediator in sepsis, has led to frustrating results.
|
30343600 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-alpha (TNF-alpha) is thought to play a major role in systemic inflammation associated with sepsis.
|
18848768 |
2009 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, 20 patients with post-surgical inflammation, 20 patients with sepsis or septic shock were included and TNFα was determined following ex vivo stimulation of whole blood with 500 pg/mL LPS.
|
28771573 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Potential immunologic mechanisms responsible for the rhIL-7 putative beneficial effect were also examined, focusing on IL-17, IL-22, IFN-γ, and TNF-α, cytokines that are critical in the control of sepsis and pulmonary Pseudomonas infections.
|
27630218 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Macrophages play an important role in the early stage of sepsis as they are tasked with eliminating invading microbes and also attracting other immune cells by the release of proinflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α.
|
31658116 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the apparent protective effect of the tumor necrosis factor B1B1 genotype on the development of severe encephalopathy may be related to the effects of this genotype on tumor necrosis factor-alpha production in sepsis.
|
9696492 |
1998 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumour Necrosis Factor-alpha and Nuclear Factor-kappa B Gene Variants in Sepsis.
|
28840846 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic association study of tumor necrosis factor-alpha with sepsis and septic shock in Thai pediatric patients.
|
23033000 |
2013 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have previously described a model of chronic alcohol ingestion followed by sepsis from cecal ligation and puncture in which alcohol-fed septic mice have higher mortality than water-fed septic mice, associated with altered gut integrity and increased production of TNF and IFNγ by splenic CD4 T cells without alterations in CD8 T cell function.
|
29664837 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, our work demonstrates the advantage of genome-scale screening with Cas9 and validates NLRX1 as a potential modulator of TNF-α-induced vascular endothelial apoptosis during sepsis.
|
30317623 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Change in DNA methylation pattern, histone modification, and microRNA regulation has been shown in sepsis models to silence or activate pro-inflammatory genes such as TNF-α and interleukins, anti-oxidant enzymes, and many signaling pathways.
|
30179122 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, treating mice with a cGMP analog after the induction of sepsis increased TNFR shedding and decreased systemic inflammation.
|
25628461 |
2015 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Unbiased hierarchical clustering identified five different clusters of sepsis mediators, including one with markers of platelet activation (e.g., thrombospondin-1) positively associated with platelet count, one with markers of inflammation (e.g., tumor necrosis factor alpha and heat shock protein 70), and endothelial dysfunction (e.g., intercellular adhesion molecule-1 and vascular cell adhesion molecule-1) negatively associated with platelet count, and another involving growth factors of thrombopoiesis (e.g., thrombopoietin), also negatively associated with platelet count.
|
29028771 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
After excluding the compounds which are previously known to intervene sepsis or which show cytotoxicity to macrophages, the compounds which show dose-dependency in inhibiting the release of IL-6 and TNF-α by the OMV-stimulated macrophages in vitro and which reduce OMV-induced SIRS in vivo are selected.
|
29683274 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate that IL-1β production during sepsis with uropathogenic <i>E. coli</i> is mediated by caspase-8, since caspase-8 and RIPK3 double knock out mice show substantially lower cytokine during sepsis and increased survival after injection of TNFα.
|
28428949 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Concomitant with a delayed increase of plasma TNF-α in ethanol-treated mice, plasma PTX3 was also suppressed in the early phase of sepsis.
|
28965650 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although KEGG showed inflammatory bowel disease in the E. coli group, the KEGG pathway analysis showed that these DEGs were mainly involved in the tumor necrosis factor signaling pathway, fructose metabolism, and mannose metabolism in both <i>S. aureus</i>- and <i>E. coli</i>-induced sepsis.
|
31093495 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, we hypothesized that TNF has a dual role in sepsis, namely a mediating and a protective role, and that protection might be obtained by TNFR1-specific inhibition.
|
31787972 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A number of pre-clinical studies have shown an auto amplification of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, and IL-6 in the first few hours after sepsis induction, also increased blood-brain barrier permeability, elevated levels of matrix metalloproteinases, increased levels of damage-associated molecular patterns were demonstrated.
|
29687346 |
2019 |