|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Timing of adequate antibiotic therapy is a greater determinant of outcome than are TNF and IL-10 polymorphisms in patients with sepsis.
|
16859504 |
2006 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped nine polymorphisms in the TNF gene and tested for an association with sepsis syndrome and outcome.
|
18434886 |
2008 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-alpha (TNF-alpha) is thought to play a major role in systemic inflammation associated with sepsis.
|
18848768 |
2009 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conducted a systematic review and meta-analysis to determine whether the TNF-alpha -308 A/G polymorphism TNF2 (G/A or A/A) confers susceptibility to sepsis or is associated with increased risk of death from sepsis.
|
19789454 |
2010 |
|
Septicemia
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Our data suggest that nucleosome repositioning controls both the induction and epigenetic silencing phases of TNFalpha transcription associated with sepsis.
|
19901031 |
2010 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Distribution of TNF-α(308) genotypes is associated with outcome, IL-10(1082) with type of microorganism and underlying cause of sepsis, and CD14(159) with type of microorganism.
|
20163933 |
2010 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of IL-1beta/-1470, IL-1beta/-511, IL-1beta/-31, IL-4/-589, IL-6/-572, IL-8/-251, IL-10/-819, and TNFalpha/-308 are susceptibility loci for the development of sepsis and organ dysfunction in major trauma patients.
|
20217044 |
2010 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therefore, the JNK1 and nNOS inhibitory pathways represent a "brake" that limits myocardial TNF-alpha expression in sepsis.
|
20237583 |
2010 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results from association study indicated that trauma patients carrying the TNF-α/-308/A allele were more likely complicated with sepsis.
|
20805766 |
2011 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, we investigated the possible association between 12 polymorphisms located in the interleukin-6 (IL6), IL10, TLR-2, Toll-like receptor-4 (TLR-4), tumor necrosis factor-α and tumor necrosis factor-β (lymphotoxin α--LTA) genes and sepsis.
|
20835611 |
2010 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To support the coordination of bioenergetics in human sepsis, we observed elevated NAD(+) levels concomitant with SIRT1 and RelB accumulation at the TNF-α promoter of endotoxin tolerant sepsis blood leukocytes.
|
21245135 |
2011 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Low TNF-α concentrations 300 min after sepsis induction could be interpreted as considerable immunosuppression during CLI sepsis.
|
21296198 |
2011 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A recent meta-analysis demonstrated that the tumor necrosis factor-α -308 A allele is associated with higher sepsis risk in adult cohorts.
|
21317641 |
2011 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Nfe2l2(-/-) mice in sepsis also generated higher hepatic TNF-α mRNA levels, lower NRF-1 and PGC-1α mRNA levels, and no enhancement of anti-inflammatory Il10, Socs3, or bcl-x(L) gene expression.
|
21454555 |
2011 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Both rs187084 and rs352162 were significantly associated with TNF-α production by peripheral blood leucocytes in response to bacterial DNA stimulation and a higher sepsis morbidity rate in patients with major trauma.
|
21633947 |
2011 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The -308G >A TNF-α SNP effect was analyzed in the entire patient group, in patients with sepsis (349/520), and in those who developed septic shock (248/520).
|
21670923 |
2011 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therapy with vitamin D in animal models of sepsis improves blood coagulation parameters in disseminated intravascular coagulation and modulates levels of systemic inflammatory cytokines including TNF-α and IL-6.
|
21777617 |
2011 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gene transcripts of TNFα were lower among patients with severe sepsis/shock than among patients with sepsis; that was not the case for TREM-1.
|
21855288 |
2012 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The whole peripheral blood samples obtained immediately after admission were stimulated with bacterial lipopolysaccharide and then determined for production of tumor necrosis factor α. Sepsis morbidity rate and multiple organ dysfunction (MOD) scores were accessed.
|
22266968 |
2012 |
|
Septicemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to evaluate the influence of SNPs LTA +252A>G, TNF-863C>A and TNF-308G>A on susceptibility to sepsis, acute respiratory distress syndrome (ARDS), septic shock and sepsis mortality.
|
22507624 |
2012 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Monocytes were isolated from 47 patients when they developed sepsis and stimulated by bacterial endotoxin for the production of TNFα and of interleukin-6 (IL-6).
|
22609212 |
2012 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Possible explanations for these outcomes include immunologic response to sepsis by a leukemia-specific T-cell response or the release of various cytokines, such as tumor necrosis factor and interleukin-2, during infections.
|
22627572 |
2012 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genetic association study of tumor necrosis factor-alpha with sepsis and septic shock in Thai pediatric patients.
|
23033000 |
2013 |
|
Septicemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Because the nuclear factor-κB (NF-κB) coupled pathway is believed to amplify inflammation prevailing in sepsis, the authors tested the hypotheses that the insertion-deletion polymorphism (-94ins/delATTG) (1) alters nuclear translocation of nuclear factor-κB and activator protein-1 (NF-κB1) in monocytes after lipopolysaccharide stimulation; (2) affects lipopolysaccharide-induced NF-κB1 messenger RNA expression, tumor necrosis factor α concentrations, and tissue factor activity; and (3) may be associated with increased 30-day mortality in patients with sepsis.
|
23249930 |
2013 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Single Nucleotide Polymorphisms (SNPs) at positions -238, -308, -376 and +489 in the promoter region of TNF gene exhibit differential association to inflammation and increased TNF production in sepsis.
|
23317877 |
2013 |