|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our aim was to compare lipid, glucose-insulin and inflammatory (tumor necrosis factor alpha; TNF-α) profiles, muscle function, energy expenditure and aerobic capacity between healthy normal-weight (NW) adults, metabolically healthy obese (MHO) and metabolically unhealthy obese (MUHO) adults; to study the associations between these outcomes and the cytokines MSTN, ADP, LP; and to establish cutoffs for MSTN and LP/ADP to identify the MUHO phenotype.
|
29246653 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the effects of berberine on obesity and insulin resistance by examining the lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4)/tumor necrosis factor (TNF)-α signaling pathway in livers of HFD-fed obese rats.
|
29365334 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, whether TNF has a protective and physiological role to control adipose tissue expansion during obesity still needs to be verified.
|
29510322 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effects of Olive Oil on TNF-α and IL-6 in Humans: Implication in Obesity and Frailty.
|
29165098 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor-α (TNF-α), peroxisome proliferator-activated receptor-γ (PPARγ), and insulin receptor substrate-1 (IRS-1) are associated with obesity, insulin resistance, and inflammation.
|
29256014 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To investigate miR-181a-5p and miR-23a-3p expression profiles in obesity and to study their role in TNFα-induced IR in adipocytes.
|
29409019 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Expression of macrophage genes within skeletal muscle correlates inversely with adiposity and insulin resistance in humans.
|
29035695 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
PWS presented similar percentage of body fat (%), lower body mass index (BMI) z-scores, insulin resistance, triglycerides, MetS severity, C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and MVPA and higher high-density lipoprotein (HDL) and adiponectin (ADP) than OB.
|
29975666 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
To further understand the characteristics of inflammation in the ovaries of obese women we analysed a panel of cytokines (IL6, IL10 and TNFα), adipokines (adiponectin, leptin and monocyte chemotactic factor 1 (MCP-1)) and acute phase proteins (C-Reactive Protein (CRP) and sICAM-1) in the ovarian follicular fluid obtained at oocyte aspiration from women (n = 48) who were lean, overweight or obese.
|
30174020 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Serum and gene expression levels of CT-1, IL-6, and TNF-α after a lifestyle intervention in obese children.
|
28749076 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Treatment Failure of TNF-α Inhibitors in Obese Patients With Inflammatory Bowel Disease-A Cohort Study.
|
29788214 |
2018 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
<b>Methods:</b> In 62 overweight/obese adults (BMI ≥ 25 kg/m<sup>2</sup>; 23F/39M), we collected data on: self-reported back pain; anthropometry [BMI, waist circumference, body composition (dual energy X-ray absorptiometry-DEXA)]; metabolic parameters [fasting glucose; insulin sensitivity (hyperinsulinaemic-euglycaemic clamps)]; cardiovascular parameters (blood pressure, lipids); serum inflammation markers [high-sensitivity C-reactive protein (hsCRP; immunoturbidimetric-assay), tumor necrosis factor-<i>alpha</i> (TNF-α), interleukin (IL)-6, and IL-10 (multiplex-assay)]; and adipokines [leptin, adipsin, resistin, and adiponectin (multiplex-assay)].
|
29483883 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Obesity is associated with high levels of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), which promotes inflammation in adipose tissue.
|
28703289 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
High tumor necrosis factor (TNF)-α production and low adiponectin levels are characteristics of obesity.
|
28946816 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Upregulated expression of resistin, vaspin, apelin and TNF-α plays a significant role in induction of insulin resistance linked with obesity and type 2 diabetes.
|
29229313 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Circulating and Adipose Tissue mRNA Levels of Zinc-α2-Glycoprotein, Leptin, High-Molecular-Weight Adiponectin, and Tumor Necrosis Factor-Alpha in Colorectal Cancer Patients With or Without Obesity.
|
29755407 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we review the current state of knowledge on how obesity affects inflammatory TNFα and IL-6 signaling in hepatocellular carcinoma and colorectal cancers.
|
30591653 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because elevated levels of the free fatty acid (FFA) palmitate and TNF-α have been reported in obesity, we studied whether these agents interact to trigger CCL2 production.
|
29632147 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Obesity is not associated with GCF and salivary resistin and TNF-α levels in children in the presence of gingival inflammation.
|
29635809 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The lower levels of CGRP, FGF, and TGF-β, and higher level of TNF-α, observed in obese mice may contribute to this observed delay in fracture healing.
|
29880016 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this regard, there exists a lack of studies in hepatic tissue about the role of TNFα receptor 1 (TNFR1) in the context of obesity and insulin resistance during the progression of nonalcoholic fatty liver disease (NAFLD).
|
29860102 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of ADAM28 with siRNA technology resulted in a lack of weight gain, promotion of insulin sensitivity/glucose tolerance and decreased liver tumour necrosis factor-α (TNF-α) levels in our diet-induced obesity mouse model as well as reduced blood urea nitrogen, alkaline phosphatase and aspartate aminotransferase.
|
28430139 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In general terms, levels of IL-1<i>β</i>, IL-6, IL-8, and tumor necrosis factor-<i>α</i> were higher in Ob people when compared to H controls.
|
28243360 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, we specifically examined the role of tumor necrosis factor-α (TNF-α), an important proinflammatory cytokine associated with obesity and a possible modulator of the Wnt pathway.
|
28402277 |
2017 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ME attenuated the influence of APOB rs512535 and TNFA rs361525 on obesity risk in FMP.WC was significantly associated to GRS.
|
28294290 |
2017 |