Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As both TNFalpha and oxidative stress independently play role in regulating cytoskeletal organization and cell survival pathways we investigated whether TNFalpha mediated oxidative stress regulates responses that offer survival advantages to glioblastoma cells.
|
19836430 |
2010 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This prompted us to evaluate the antitumor effects of recombinant parvoviruses designed to deliver IP-10 or TNF-alpha into a glioblastoma.
|
18670452 |
2009 |
Childhood Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we have examined two non-chemotherapeutic agents for synergistic effects: lovastatin and Tumor Necrosis Factor (TNF)-related apoptosis-inducing ligand (TRAIL) for synergistic effects; on three human malignant glioblastoma cell lines, M059K, M59J, and A172.
|
17928957 |
2008 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As glioblastoma are resistant to the cytotoxic effect of TNFalpha, we investigated the potential of Ebselen in sensitizing glioma cells to TNFalpha-induced apoptosis.
|
18709644 |
2008 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Growth inhibition and radiosensitization of glioblastoma and lung cancer cells by small interfering RNA silencing of tumor necrosis factor receptor-associated factor 2.
|
18794145 |
2008 |
Childhood Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The current study examined the role of SphK activity in TNF-alpha-stimulated cell proliferation in 1321N1 glioblastoma cells.
|
17114809 |
2007 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that anisomycin and death receptor ligand anti-Fas antibody CH-11 or tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) synergistically induce apoptosis in multiple human glioblastoma cell lines.
|
17699104 |
2007 |
Childhood Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Apoptosis in human glioblastoma cells produced using embryonic stem cell-derived astrocytes expressing tumor necrosis factor-related apoptosis-inducing ligand.
|
16871882 |
2006 |
Childhood Glioblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Inhibition of DNA methylation sensitizes glioblastoma for tumor necrosis factor-related apoptosis-inducing ligand-mediated destruction.
|
16357155 |
2005 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transcriptional targeting of adenovirally delivered tumor necrosis factor alpha by temozolomide in experimental glioblastoma.
|
15374943 |
2004 |
Childhood Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Microarray analysis of tumor necrosis factor alpha induced gene expression in U373 human glioblastoma cells.
|
14641910 |
2003 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To exploit this tropism to develop a therapeutic strategy that targeted tumor satellites, we inoculated human glioblastoma xenografts with tumor necrosis factor-related apoptosis-inducing ligand-secreting NSCs.
|
12499252 |
2002 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Effects of retinoic acid and tumor necrosis factor alpha on GL-15 glioblastoma cells.
|
10674492 |
2000 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Experiments were carried out in a nude mouse model of human glioblastoma to determine whether gamma-knife radiosurgery combined with herpes simplex virus thymidine kinase (tk) suicide gene therapy and tumor necrosis factor alpha (TNFalpha) gene transfer provided an improved multimodality treatment of this disease.
|
10947938 |
2000 |
Childhood Glioblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor microsatellite polymorphisms in Italian glioblastoma patients.
|
10087955 |
1999 |
Childhood Glioblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells.
|
8912851 |
1996 |
Childhood Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
p55 and p75 tumor necrosis factor receptor expression on human glioblastoma cells.
|
7566386 |
1995 |
Childhood Glioblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Modulation of proliferation and antigen expression of a cloned human glioblastoma by interleukin-4 alone and in combination with tumor necrosis factor-alpha and/or interferon-gamma.
|
8413882 |
1993 |