|
Malaria
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The frequency of the TNF U04 allele designated -1031C, -863C, and -857C was found to be significantly greater in patients with cerebral malaria than in patients with mild malaria (12.6%, cerebral malaria vs 5.6%, mild malaria; odds ratio =2.5; P=0.002).
|
17493155 |
2007 |
|
Malaria
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although molecular interactions between TNF-alpha and PGE2 are largely unexplored in human malaria, results presented here show that pfHz-induced suppression of PBMC COX-2 gene products induces overproduction of TNF-alpha.
|
16619186 |
2006 |
|
Malaria
|
0.400 |
Biomarker
|
disease |
BEFREE |
The hypothesis that tumor necrosis factor (TNF) aggravates malaria in children is supported by observations that TNF polymorphisms and high TNF levels have been associated with cerebral malaria.
|
16982833 |
2006 |
|
Malaria
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
In conclusion, our study suggests that several TNF variants may be part of the genetic determinants for maximum parasitemia and/or mild malaria attack.
|
15931230 |
2005 |
|
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The association tests with mild malaria attack suggest a moderate effect of TNF-308 polymorphism.
|
15931230 |
2005 |
|
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Associations between frequencies of a susceptible TNF-alpha promoter allele and protective alpha-thalassaemias and malaria parasite incidence in Vanuatu.
|
15941417 |
2005 |
|
Malaria
|
0.400 |
Biomarker
|
disease |
BEFREE |
These observations suggest that the control of the TNF-alpha production in malaria by monocytes was not entirely dependent on the phagocytosis of PEs by CD36 and that soluble factors produced by PEs could play a role in this process.
|
15986606 |
2005 |
|
Malaria
|
0.400 |
Biomarker
|
disease |
BEFREE |
Elevated production of TNF-alpha has been found to be associated with several infectious diseases including malaria.
|
14968205 |
2004 |
|
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mutations in beta-globin, glucose-6-phosphate dehydrogenase, and promoters for tumor necrosis factor-alpha and inducible nitric oxide synthase (iNOS) were examined for associations with the incidence of symptomatic malaria in a cohort of 307 Ugandan children.
|
15642965 |
2004 |
|
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In general, case-control studies have produced mixed results, with little consensus in most cases on whether any TNF polymorphisms are actually associated with disease, although results have been more consistent in the case of infectious diseases, particularly malaria.
|
14973548 |
2004 |
|
Malaria
|
0.400 |
Biomarker
|
disease |
LHGDN |
The presence of TNF-alpha in cord blood was not associated with malaria infection.
|
12496175 |
2003 |
|
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
TNF polymorphisms have been associated with susceptibility to malaria and other infectious and inflammatory conditions.
|
14551600 |
2003 |
|
Malaria
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor alpha (TNF alpha) is thought to be a critical mediator of malaria fever, and mild malaria was previously reported to be linked to the MHC region containing the tumor necrosis factor alpha gene (TNF).
|
12566384 |
2003 |
|
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results show that this particular TNF promoter allele increases the risk of reinfection with the malaria parasite P. falciparum.
|
12135427 |
2002 |
|
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Tumor necrosis factor-alpha promoter variant 2 (TNF2) is associated with pre-term delivery, infant mortality, and malaria morbidity in western Kenya: Asembo Bay Cohort Project IX.
|
11668577 |
2001 |
|
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
For example, tumour necrosis factor polymorphisms have been associated with susceptibility to malaria and other infections; chemokine receptor polymorphisms with susceptibility to HIV; natural resistance-associated macrophage protein 1 with tuberculosis; and mannose binding lectin polymorphisms with meningococcal disease.
|
10786964 |
2000 |
|
Malaria
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Significantly increased expression of interleukin (IL)-1beta, IL-8, and tumor necrosis factor (TNF)-alpha and decreased expression of IL-6 and transforming growth factor-beta1 were found in malaria-infected compared with uninfected placentas.
|
10558956 |
1999 |
|
Malaria
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A previously described nucleotide variation at position -308 in the promoter region of the human TNF gene was shown to be associated with the clinical outcome of malaria.
|
8832971 |
1997 |
|
Malaria
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Some studies have found higher serum levels of TNF in lepromatous than tuberculoid leprosy, and high TNF levels are found in malaria and leishmaniasis, which are also associated with this TNF allele.
|
9237725 |
1997 |
|
Malaria
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion we observed circulating TNF concentrations in malaria patients dependent on the severity of disease, which is itself dependent on age, and an association of a high TNF production capacity with parameters for accelerated cure and good prognosis.
|
9110145 |
1997 |
|
Malaria
|
0.400 |
Biomarker
|
disease |
CTD_human |
|
|
|