Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
RGD |
Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns.
|
21171972 |
2010 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Patients with first-in-life stroke were analysed according to: plasma concentration of the following markers on the first day of stroke: interleukin 2 (IL-2) and interleuki 6 (IL-6), S100B, tumor necrosis factor-α (TNF-α), progranulin (GRN), neuron specific enolase (NSE), urokinase-type plasminogen activator (uPA), vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), C-reactive protein (CRP), leucocyte and thrombocyte counts; their neurological status on the first day of stroke (NIHSS) and their functional status at 30 days following stroke (mRS).
|
31356182 |
2019 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
The reduced release of TNFα and IP-10 after ex vivo blood stimulation with endotoxin is independently associated with poor outcome after stroke.
|
29275013 |
2018 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
These findings strongly implicate the involvement of TNF-α in the pathogenesis of stroke.
|
23050663 |
2012 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
CTD_human |
The novel beta-blocker, carvedilol, provides neuroprotection in transient focal stroke.
|
10950380 |
2000 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
We also subjected TNF knockout mice to experimental stroke (permanent middle cerebral artery occlusion) and validated the effect of TNF inhibition on EV release.
|
29807527 |
2018 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor (TNF) has been shown to be involved in the pathogenesis of hemorrhagic stroke, having deleterious effects on cerebral arteries by promoting inflammation and apoptosis in vascular and immune cells.
|
27809686 |
2017 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Primary rat neuronal cells were subjected to a 90-minute HBOT treatment at 2.5 absolute atmospheres prior to either tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS) injury to simulate the inflammation-plagued secondary cell death associated with stroke and traumatic brain injury (TBI).
|
30972972 |
2019 |
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor- alpha (TNF-alpha), an important immune mediator, may contribute to the initiation and progression in the stroke.
|
19168815 |
2009 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The aim of this replication study was to confirm our previous findings of associations between the TNF(-308) G/A, IL4R 503 S/P, and ADRB2 27 Q/E polymorphisms and large vessel stroke risk.
|
17600229 |
2007 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and ischemic stroke: a meta-analysis.
|
17452160 |
2007 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
It was examined whether G to A promoter polymorphism in the tumor necrosis factor-alpha gene at position -308 affects the risk of stroke.
|
16473522 |
2006 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes.
|
16879054 |
2006 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
This study was designed to detect wether the TNF2 allele is associated with disease progression in MS. We examined the TNFalpha -308 polymorphism with an allelic discrimination PCR to detect the G-->A transition in the genomic DNA of 283 MS patients from Germany and in 72 patients with amyotrophic lateral sclerosis (ALS) and 66 with stroke from the same genetic background who served as controls.
|
10552245 |
1999 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The combination of TNF (-308)GG homozygosity and the IL4R 503P variant carrier status was associated with a particularly strong predisposition to LV stroke (odds ratio [OR] = 5.5; 95% confidence interval [CI] = 2.3-13.1).
|
14615367 |
2004 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Cumulative incidence of stroke was significantly higher for children with TNF-α A allele (p=0.02) and lower for children with HBA deletion (p=0.02).
|
25175566 |
2015 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes.
|
16879054 |
2006 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
LHGDN |
The aim of this replication study was to confirm our previous findings of associations between the TNF(-308) G/A, IL4R 503 S/P, and ADRB2 27 Q/E polymorphisms and large vessel stroke risk.
|
17600229 |
2007 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Possession of the TNF-alpha T allele significantly increases the risk of vascular dementia, and increases the risk of Alzheimer's disease associated with apolipoprotein E. Although further research is needed, these findings suggest a potential role for anti-inflammatory therapy in vascular dementia and Alzheimer's disease, and perhaps especially in patients who have had a stroke.
|
11273064 |
2001 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-alpha genes, but not the interleukin-1beta gene.
|
15036607 |
2004 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
IL-6, CRP, IL-10, and TNF superfamily gene variation was not associated with MI or stroke risk.
|
17981284 |
2008 |
Cerebrovascular accident
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Recent reports suggested that tumor necrosis factor-α (TNF-α) (-308) polymorphism is an important risk factor for stroke in children with SCA.
|
21160173 |
2011 |