|
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
We demonstrate that therapeutic approaches targeting synergistic IL-17 and tumor necrosis factor-α pathways in parallel offer additional neuroprotection in stroke.
|
28611085 |
2017 |
|
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
RGD |
Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns.
|
21171972 |
2010 |
|
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Patients with first-in-life stroke were analysed according to: plasma concentration of the following markers on the first day of stroke: interleukin 2 (IL-2) and interleuki 6 (IL-6), S100B, tumor necrosis factor-α (TNF-α), progranulin (GRN), neuron specific enolase (NSE), urokinase-type plasminogen activator (uPA), vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), C-reactive protein (CRP), leucocyte and thrombocyte counts; their neurological status on the first day of stroke (NIHSS) and their functional status at 30 days following stroke (mRS).
|
31356182 |
2019 |
|
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
The reduced release of TNFα and IP-10 after ex vivo blood stimulation with endotoxin is independently associated with poor outcome after stroke.
|
29275013 |
2018 |
|
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
These findings strongly implicate the involvement of TNF-α in the pathogenesis of stroke.
|
23050663 |
2012 |
|
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
CTD_human |
The novel beta-blocker, carvedilol, provides neuroprotection in transient focal stroke.
|
10950380 |
2000 |
|
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
We also subjected TNF knockout mice to experimental stroke (permanent middle cerebral artery occlusion) and validated the effect of TNF inhibition on EV release.
|
29807527 |
2018 |
|
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor (TNF) has been shown to be involved in the pathogenesis of hemorrhagic stroke, having deleterious effects on cerebral arteries by promoting inflammation and apoptosis in vascular and immune cells.
|
27809686 |
2017 |
|
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Primary rat neuronal cells were subjected to a 90-minute HBOT treatment at 2.5 absolute atmospheres prior to either tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS) injury to simulate the inflammation-plagued secondary cell death associated with stroke and traumatic brain injury (TBI).
|
30972972 |
2019 |
|
Cerebrovascular accident
|
0.600 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor- alpha (TNF-alpha), an important immune mediator, may contribute to the initiation and progression in the stroke.
|
19168815 |
2009 |
|
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
TNF-α and PON total methylation levels correlated each other (r = 0.44; p = 0.031), especially in stroke patients (r = 0.72; p = 0.008).
|
24500802 |
2014 |
|
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
These findings indicate the important roles that TNF-α and IL-1β serum levels play regarding the risk of PSD, particularly during the acute phase of stroke and in patients with genetic susceptibility.
|
28844626 |
2017 |
|
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Up-regulated TNF-α expression has also been found in various neurodegenerative diseases such as cerebral malaria, AIDS dementia, Alzheimer's disease, multiple sclerosis, and stroke, suggesting a potential pathogenic role of TNF-α in these diseases as well.
|
21298033 |
2011 |
|
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Serum levels of TNF-α, C-reactive protein (CRP), IL-4, IL-6, IL-10, IL-17, IL-23, and TGF-β increased, whereas serum level of IFN-γ decreased at all time points after stroke.
|
27682880 |
2017 |
|
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Quantitative PCR analysis of whole cell lysate as well as flow-sorted myeloid cells from the perilesional cortex showed increased cellular interleukin 1 beta (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNF-α) mRNA levels but reduced plasma levels of these cytokines in MS P2X4R KO mice after stroke.
|
28751018 |
2017 |
|
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Moreover, plasma H19 levels showed a positive correlation with National Institute of Health Stroke Scale score and tumor necrosis factor-α levels.
|
28630232 |
2017 |
|
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
<b>Results:</b> MCAo resulted in profound attenuation of immune activation, as anticipated. t-PA treatment not only worsened neurological deficit, but further reduced lymphocyte and monocyte counts in blood, enhanced plasma levels of both IL-10 and TNFα and decreased various conventional DC subsets in the spleen and cLN, consistent with enhanced immunosuppression and systemic inflammation after stroke.
|
30972077 |
2019 |
|
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
LHGDN |
The release of tumor necrosis factor-alpha is associated with ischemic tolerance in human stroke.
|
14681891 |
2003 |
|
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
We investigated whether gradual increases in tumor necrosis factor-alpha (TNF-alpha) reported during exercise down-regulates expression of TNF-alpha receptors I and II (TNFRI and II) in stroke, leading to reduced brain damage.
|
17109621 |
2006 |
|
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Injection of lentiviral miR-126-5p improved behavioral outcomes at 3 days after stroke (<i>P</i><0.05). miR-126-3p and -5p overexpression downregulated the expression of proinflammatory cytokines IL-1β and TNF-α and adhesion molecules VCAM-1 and E-selectin, as well as decreased MPO<sup>+</sup> (myeloperoxidase positive) cell numbers at 3 days after ischemia (<i>P</i><0.05).
|
31822249 |
2020 |
|
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Alveolar macrophages and epithelial and endothelial cells of Sham and Stroke animals were also isolated for evaluation of mRNA expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-α.
|
30290827 |
2018 |
|
Cerebrovascular accident
|
0.600 |
AlteredExpression
|
group |
BEFREE |
This work was designed to examine the effect of mouse recombinant resistin on mRNA expression of Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-10 (IL-10), Transforming growth factor-β1 (TGF- β1), and Heat shock protein-70 (HSP-70) in mouse model of stroke.
|
30120034 |
2018 |