TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE Cumulative incidence of stroke was significantly higher for children with TNF-α A allele (p=0.02) and lower for children with HBA deletion (p=0.02). 25175566 2015
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Patients with first-in-life stroke were analysed according to: plasma concentration of the following markers on the first day of stroke: interleukin 2 (IL-2) and interleuki 6 (IL-6), S100B, tumor necrosis factor-α (TNF-α), progranulin (GRN), neuron specific enolase (NSE), urokinase-type plasminogen activator (uPA), vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), C-reactive protein (CRP), leucocyte and thrombocyte counts; their neurological status on the first day of stroke (NIHSS) and their functional status at 30 days following stroke (mRS). 31356182 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE The reduced release of TNFα and IP-10 after ex vivo blood stimulation with endotoxin is independently associated with poor outcome after stroke. 29275013 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE These findings strongly implicate the involvement of TNF-α in the pathogenesis of stroke. 23050663 2012
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE We investigated whether gradual increases in tumor necrosis factor-alpha (TNF-alpha) reported during exercise down-regulates expression of TNF-alpha receptors I and II (TNFRI and II) in stroke, leading to reduced brain damage. 17109621 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE We also subjected TNF knockout mice to experimental stroke (permanent middle cerebral artery occlusion) and validated the effect of TNF inhibition on EV release. 29807527 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Tumor necrosis factor (TNF) has been shown to be involved in the pathogenesis of hemorrhagic stroke, having deleterious effects on cerebral arteries by promoting inflammation and apoptosis in vascular and immune cells. 27809686 2017
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE Possession of the TNF-alpha T allele significantly increases the risk of vascular dementia, and increases the risk of Alzheimer's disease associated with apolipoprotein E. Although further research is needed, these findings suggest a potential role for anti-inflammatory therapy in vascular dementia and Alzheimer's disease, and perhaps especially in patients who have had a stroke. 11273064 2001
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Primary rat neuronal cells were subjected to a 90-minute HBOT treatment at 2.5 absolute atmospheres prior to either tumor necrosis factor-alpha (TNF-alpha) or lipopolysaccharide (LPS) injury to simulate the inflammation-plagued secondary cell death associated with stroke and traumatic brain injury (TBI). 30972972 2019
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group BEFREE Tumor necrosis factor- alpha (TNF-alpha), an important immune mediator, may contribute to the initiation and progression in the stroke. 19168815 2009
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Injection of lentiviral miR-126-5p improved behavioral outcomes at 3 days after stroke (<i>P</i><0.05). miR-126-3p and -5p overexpression downregulated the expression of proinflammatory cytokines IL-1β and TNF-α and adhesion molecules VCAM-1 and E-selectin, as well as decreased MPO<sup>+</sup> (myeloperoxidase positive) cell numbers at 3 days after ischemia (<i>P</i><0.05). 31822249 2020
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE IL-6, CRP, IL-10, and TNF superfamily gene variation was not associated with MI or stroke risk. 17981284 2008
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE Alveolar macrophages and epithelial and endothelial cells of Sham and Stroke animals were also isolated for evaluation of mRNA expression of interleukin (IL)-6 and tumor necrosis factor (TNF)-α. 30290827 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group BEFREE This work was designed to examine the effect of mouse recombinant resistin on mRNA expression of Tumor necrosis factor-α (TNF-α), Interleukin-1β (IL-1β), Interleukin-10 (IL-10), Transforming growth factor-β1 (TGF- β1), and Heat shock protein-70 (HSP-70) in mouse model of stroke. 30120034 2018
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group BEFREE Recent reports suggested that tumor necrosis factor-α (TNF-α) (-308) polymorphism is an important risk factor for stroke in children with SCA. 21160173 2011
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group CTD_human The novel beta-blocker, carvedilol, provides neuroprotection in transient focal stroke. 10950380 2000
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group LHGDN Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and ischemic stroke: a meta-analysis. 17452160 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 AlteredExpression group LHGDN The release of tumor necrosis factor-alpha is associated with ischemic tolerance in human stroke. 14681891 2003
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group LHGDN Following multivariate adjustment, carriers of the TNF-alpha (-308)A allele, the IL-1-RA 2* allele or the IL-6 (-174)C allele appeared to have an increased risk of stroke in association with a febrile episode prior to strokes. 16879054 2006
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group LHGDN The aim of this replication study was to confirm our previous findings of associations between the TNF(-308) G/A, IL4R 503 S/P, and ADRB2 27 Q/E polymorphisms and large vessel stroke risk. 17600229 2007
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 GeneticVariation group LHGDN Susceptibility for ischemic stroke in Korean population is associated with polymorphisms of the interleukin-1 receptor antagonist and tumor necrosis factor-alpha genes, but not the interleukin-1beta gene. 15036607 2004
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident
0.600 Biomarker group RGD Dynamics of neuroinflammation in the macrosphere model of arterio-arterial embolic focal ischemia: an approximation to human stroke patterns. 21171972 2010