|
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
After adjusting for eGFR, albuminuria, and other traditional cardiovascular risk factors, anemia (1.37, 95% CI 1.09, 1.72, <i>P</i>=0.006), insulin resistance (1.16, 95% CI 1.04, 1.28, <i>P</i>=0.006), hemoglobin A1c (1.27, 95% CI 1.14, 1.41, <i>P</i><0.001), interleukin-6 (1.15, 95% CI 1.05, 1.25, <i>P</i>=0.002), and tumor necrosis factor-α (1.10, 95% CI 1.00, 1.21, <i>P</i>=0.05) were all significantly and directly associated with incidence of heart failure.
|
28515118 |
2017 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
We will analyze the role of some receptor mediated signaling pathways such as natriuretic peptides, mediators of glycogen synthase kinase 3 and ERK1/2 pathways, beta-adrenergic receptor subtypes and relaxin receptor signaling mechanisms, TNF/TNF receptor family and TWEAK/Fn14 axis, and some micro-RNAs as candidate target pathways in pathogenesis of heart failure.
|
27409295 |
2016 |
|
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.
|
22921902 |
2012 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
A polymorphism within tumor necrosis factor-α (TNF-α) gene promoter and contribution of TNF-α converting enzyme (TACE) have been reported to be associated with TNF-α production which may increase susceptibility to heart failure such as acute myocardial infarction (AMI).
|
21153921 |
2011 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The role of inflammatory signaling is discussed and TLR4 signaling, IL-1β, TNFα and IL-6 expression appears to coincide with the development of heart failure.
|
21503626 |
2011 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
TNFα in myocardial ischemia/reperfusion, remodeling and heart failure.
|
20571888 |
2011 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Transforming growth factor-beta receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factor.
|
18034274 |
2008 |
|
Heart failure
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The TNF-alpha gene promoter polymorphism G/A at position -308 has been associated with enhanced TNF-alpha secretion, as has been heart failure.
|
18450464 |
2008 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Comparing Type D personality and older age as correlates of tumor necrosis factor-alpha dysregulation in chronic heart failure.
|
18068948 |
2008 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we show that p8, a small stress-inducible basic helix-loop-helix protein, is required for endothelin- and alpha-adrenergic agonist-induced cardiomyocyte hypertrophy and for tumor necrosis factor-stimulated induction, in cardiac fibroblasts, of matrix metalloproteases (MMPs) 9 and 13-MMPs linked to general inflammation and to adverse ventricular remodeling in heart failure.
|
17116693 |
2007 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Tumor necrosis factor-alpha (TNF-alpha) is a proinflammatory cytokine that has been implicated in the pathogenesis of heart failure.
|
17337591 |
2007 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The higher TNFalpha gene expression in patients with compensated heart failure suggests that cytokine gene expression has an adaptive role in the early phase of LV remodelling.
|
15958363 |
2005 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increasing evidence suggests that development of heart failure involves activation of stress-response inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-6.
|
15867183 |
2005 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4.
|
15231041 |
2004 |
|
Heart failure
|
0.600 |
Therapeutic
|
disease |
RGD |
New insights into the pathological role of TNF-alpha in early cardiac dysfunction and subsequent heart failure after infarction in rats.
|
15210453 |
2004 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF)-alpha has been implicated in the pathophysiology of heart failure.
|
15189946 |
2004 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
LHGDN |
TNFalpha in patients with congestive heart failure.
|
14685701 |
2004 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
CTD_human |
Heart failure may in fact be accentuated by a downregulation of myocardial TNF-alpha.
|
15135663 |
2004 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Circulating plasma concentrations of pro-inflammatory cytokines (e.g., tumor necrosis factor [TNF]-alpha and interleukin [IL]-6) are elevated in patients with heart failure and these cytokines have been shown to down-regulate CYP enzyme activity.
|
12411982 |
2002 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
[The effects of exercise training on plasma tumor necrosis factor-alpha, blood leucocyte and its components in congestive heart failure patients].
|
12133434 |
2002 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Tumour necrosis factor alpha (TNF alpha) is implicated in the pathophysiology of heart failure.
|
11796554 |
2002 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
We studied the cytokines tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta and IL-6 and the terminal stage of the apoptotic pathway in patients with decompensating heart failure who required LVAD support and compared them with patients with less severe heart failure undergoing elective heart transplantation.
|
11568062 |
2001 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
This article will review recent clinical and experimental material which suggests that tumor necrosis factor (TNF), a pro-inflammatory cytokine, may contribute to disease progression in heart failure by virtue of the direct toxic effects that this molecule exerts on the heart and circulation.
|
11309526 |
2001 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Clinical indices of heart failure were retrospectively analyzed and correlated with myocardial TNFalpha expression.
|
11789791 |
2001 |
|
Heart failure
|
0.600 |
Therapeutic
|
disease |
RGD |
Tumor necrosis factor-alpha (TNF-alpha) probably affects the pathogenesis of heart failure.
|
11668085 |
2001 |