|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF)-α activates a diverse array of signaling pathways in vascular endothelial cells (ECs), leading to the inflammatory phenotype that contributes to the vascular dysfunction and neutrophil emigration in patients with sepsis.
|
29493888 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Basophil-derived tumor necrosis factor can enhance survival in a sepsis model in mice.
|
30664762 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Role of chemically modified tetracycline on TNF-alpha and mitogen-activated protein kinases in sepsis.
|
15489642 |
2004 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-alpha (TNF-alpha) is a well-documented central inflammatory mediator in sepsis.
|
12906716 |
2003 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Sepsis is more common in the elderly.TNF⍺ is recognized as an important mediator in sepsis and Toll-like receptors (TLRs) play an important role in initiating signaling cascades to produce TNF⍺.
|
30402800 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This work investigated the influence of aqueous ethanol extract of whole plant of SOL and contribution of its main components on inflammation METHODS AND RESULTS: Oral administration of SOL (10 mg/kg) to mice reduced the expression of inflammatory cytokines including IL-6, IL-1β, and TNF-α, in the LPS-induced sepsis mouse model.
|
30802614 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated HRG's role in the LPS/TNF-α-induced barrier dysfunction of endothelial cells in vitro and in vivo and the possible mechanism, to clarify the definitive roles of HRG in sepsis.
|
31093964 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor (TNF)-α is a pleiotropic cytokine with intense pro-inflammatory and immunomodulatory properties, and anti-TNF-α biologics are effective therapies for various inflammatory diseases such as inflammatory bowel disease (IBD) and sepsis.
|
27879679 |
2016 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In vivo, IAL reduced the secretion of IL-6 and TNF-α in serum, and increased the survival rate of mice with LPS-induced sepsis.
|
28407580 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
This new mechanistic understanding of endothelial regulation and the modulation of tumor necrosis factor-induced endothelial dysfunction creates a novel link between coagulation, inflammation, and cell death and provides insight into the molecular basis for the efficacy of APC in systemic inflammation and sepsis.
|
11278252 |
2001 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We identified MMP13 as an important mediator in sepsis and IBD via the shedding of TNF.
|
23723167 |
2013 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor alpha (TNF-alpha) has well-described effects on lipid metabolism in the context of acute inflammation, as in sepsis.
|
10878750 |
2000 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-38 administration decreased the inflammatory response, as reflected by lower levels of cytokines and chemokines (including IL-6, TNF-α, interleukin 10, interleukin 17, interleukin 27, CXCL1, and CCL2), and less damage to tissues (including lung, liver, and kidney) in CLP-induced sepsis.
|
29762676 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Most common serious adverse events were sepsis and thrombotic events observed in 8 and 4 patients, respectively.Treatment with anti-TNFs may be associated with a higher survival rate compared with historic cohorts of AA amyloidosis, especially when started early with a lower serum creatinine level at baseline.
|
28834898 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The mouse model of sepsis was then established and the serum was extracted to detect interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α).
|
30915758 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Significant reductions in the levels of circulating interleukin-6 (<i>P</i> = 0.046) and tumor necrosis factor-α (<i>P</i> = 0.008) were found in the sepsis group.
|
30666251 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-alpha (TNF-α) is a pivotal mediator that triggers inflammatory process, oxidative stress, and multiple organ injury in sepsis.
|
28459157 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Therefore, culture- and next-generation sequencing (NGS)-based fungal findings as well as corresponding plasma levels of β-d-glucan, interferon gamma (INF-γ), tumor necrosis factor alpha (TNF-α), interleukin (IL)-2, -4, -6, -10, -17A, and mid-regional proadrenomedullin (MR-proADM) were evaluated in 50 septic patients at six consecutive time points within 28 days after sepsis onset.
|
28820494 |
2017 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Low TNF-α concentrations 300 min after sepsis induction could be interpreted as considerable immunosuppression during CLI sepsis.
|
21296198 |
2011 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lipopolysaccharide stimulates the production and the release of numerous endogenous mediators of sepsis: tumor necrosis factor alpha, interleukin-1, and interleukin-6 that induce fever production.
|
10085413 |
1999 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-alpha (TNF-alpha) plays a central role in the pathophysiology of sepsis.
|
8843235 |
1996 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results revealed that combined treatment in pediatric burn sepsis patients decreased the inflammatory cytokine tumor necrosis factor α and interleukin (IL)-1β serum levels, whereas it increased IL-10 and human leukocyte antigen-D related levels.
|
29599842 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
By combining phenotypic analysis of exhaustion markers with functional analysis of cytokine production, we found that PD-1+ CD4+ cells in cancer hosts failed to make any cytokines following CLP, while the 2B4+ PD-1lo cells in cancer mice secreted increased TNF during sepsis.
|
29338031 |
2018 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The α7 nAChR partial agonist GTS-21 reduces secretion of pro-inflammatory cytokines including interleukin-6 (IL6) and tumor-necrosis factor (TNF) in models of endotoxemia and sepsis, and its anti-inflammatory effects are widely ascribed to α7 nAChR activation.
|
30947238 |
2019 |
|
Septicemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We challenged human endothelial cells simultaneously with tumor necrosis factor alpha (TNFalpha) and thrombin because many pathophysiological conditions, such as sepsis, diabetes, and coronary artery disease, result in the concurrent presence of circulating inflammatory mediators and activated thrombin.
|
15201277 |
2004 |