|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
TNBS significantly elevated myeloperoxidase (MPO) expression, macroscopic scores, and colon shortening.Oral <i>L. sakei</i> S1 administration resulted in reduction of TNBS-induced loss in body weight, colon shortening, MPO activity, expression of cyclooxygenase (COX)-2, inducible nitric oxide synthase (iNOS) and nuclear factor-kappa B (NF-κB).<i>L. sakei</i> S1 inhibited the expression of inflammatory cytokines IL-1β, IL-6 and TNF-α, induced by TNBS, but enhanced IL-10 expression.<i>L. sakei</i> S1 showed resistance to artificial digestive juices and adherence to intestinal epithelial Caco-2 cells.Thus, <i>L. sakei</i> S1 may inhibit the NF-κB pathway and be used as functional food to treat colitis.
|
31635441 |
2020 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Both the CSF-1 and the TNFα gene sets were enriched in the colonic mucosal transcriptomes of Crohn's disease and in mouse colitis, and expression of both gene sets was highest in patients who did not respond to anti-TNFα therapy.
|
31710624 |
2019 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, probiotic VSL#3 inhibits the expression of NF-κB and TNF-α in rats with colitis through TLR4-NF-κB signal pathway, so it is expected to be a first choice drug for the treatment of colitis.
|
31497551 |
2019 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found that the incubation of MSCs with TNF-α and IFN-γ aggravates colitis, where high levels of pro-inflammatory factors, such as interleukin (IL)-17, IL-8, IL-12, IL-1β, transforming growth factor (TGF)-β, TNF-α and IFN-γ, were secreted.
|
31632588 |
2019 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Induction of colitis and JGT treatment changed compositions of gut microbiota and inflammatory cytokine levels (TNF-<i>α</i> and IL-6).
|
30800169 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
DAI evaluation, colon length, colon tissue morphology, histologic damage scores and relative protein concentrations (MPO, TNF-α and IL-1β) demonstrated that the Alg/Chi/IL-1Ra microcapsules alleviated DSS-induced colitis in mice.
|
30779979 |
2019 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, we use the mucosal delivery of Lactococcus lactis carrying an anti-TNFα scFv expression plasmid on a DSS-induced colitis model in mice.
|
31238939 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our study demonstrates that the LB-9 probiotic exhibits therapeutic potential for UC through suppression of TNF-α-mediated IEC apoptosis in a murine DSS-induced colitis model, with important biological implications for treatment of IBD in humans.
|
30615542 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Only one patient required tumor necrosis factor-α owing to grade 3 colitis.
|
30870270 |
2019 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
VSG-induced increases in colitis were associated with increased colonic expression of TNF-α, IL-6, MCP-1, and microRNA-21.
|
30623320 |
2019 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It was observed that separate and combined administrations of FO and mesalazine decreased the increase in the serum and tissue TNF-α and IL-6 levels caused by colitis (p < 0.05).
|
31351432 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
When human colon cancer cells were xenografted into these mice, prophylactic blockade of human TNF improved colitis and hepatitis in xenografted mice, and moreover, immunotherapeutic control of xenografted tumours was retained.
|
31043740 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
(2019) identify important roles of TNF-producing T cells as both regulators of gut development and potential inducers of colitis.
|
30784573 |
2019 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CRYAB was found to be significantly decreased in the inflamed mucosa from IBD patients and DSS-induced colitis in mice, and negatively correlated with the levels of TNF-α and IL-6, respectively.
|
31481750 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results showed that IL-6 and TNF-α may influence the deterioration effect of colitis in arthritic mice.
|
31366877 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent animal studies have shown that concurrent treatment with anti-TNFα and ICIs improves tumor responses and decreases colitis severity.
|
31439050 |
2019 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additionally, these agents decreased the activity of MPO (<i>p</i> ˂ .001), TNF-α (<i>p</i> ˂ .001) and the expression level of p-NF-kB (<i>p</i> ˂ .001) in rat colon tissue compared with the acetic acid group.<b>Conclusion:</b> It is proposed that the anti-inflammatory activity of dapsone on acetic acid-induced colitis in rats may involve the inhibition of NF-kB pathway.
|
31621446 |
2019 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The characterization of the tincture included common phytochemical screening assays for antioxidant capacity measurement, cell viability assays on Caco-2 colon cells, and in vivo assessment of antioxidant and anti-inflammatory effects by histopathological and ultrastructural analysis of the intestinal mucosa, measurement of reduced glutathione, lipid peroxidation, and gene expression of the inflammation markers (interleukin-6 and tumor necrosis factor-α) in intestine after oral administration to an experimental mouse model of colon inflammation (colitis) developed by intrarectal administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS).
|
31546840 |
2019 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Intrarectal calprotectin protected significantly against colitis, as shown by lower levels of macroscopic and microscopic damage, colonic myeloperoxidase activity and decreased expression of TNFα and toll-like receptor 4.
|
30007036 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Neutralization of TNF-α in dextran sulfate sodium (DSS)-induced colitis mice demonstrates improved the outcomes, and the therapeutic effect of the TNF-α neutralizing mAb is mediated in part by the preservation of DRA expression.
|
29330471 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In vivo: KLD significantly improves body weight, clinical score, histological score and large intestine length of mice with DSS-induced colitis and reduces TNF-α, IL-1β and IL-6 mRNA levels, while increases IL-10 mRNA and VDR levels.
|
29633636 |
2018 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We found that more inflammatory cells, with expression of tumor necrosis factor α, were infiltrated in double knockout mouse colitis compared with that in wild-type mice.
|
29350564 |
2018 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In this study, we compared the benefits of an angiotensin-converting enzyme (ACE) inhibitor, enalapril, an angiotensin receptor blocker, losartan and their combination in dextran sodium sulfate (DSS)-induced colitis in mice by assessing the histopathological and macroscopic changes in the colon, and by measuring the expression of the pro-inflammatory interleukin 1beta (IL-1β) and tumor necrosis factor alpha (Tnf-α) genes.
|
30415241 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Next, we orally administered GC-modified NPs loaded with TNF-α siRNA to C57BL/6 mice treated with 3% dextran sodium sulfate (DSS) to investigate their use in the treatment of colitis.
|
30315858 |
2018 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Importantly, MKP-1 small interfering RNA (siRNA), but not control siRNA, significantly abrogated the Gln-mediated (1) induction of MKP-1; (2) attenuation of colitis (colon length, histological abnormality, and inflammation; and (3) inhibition of cPLA₂ phosphorylation and colonic levels of TNF-α and LTB₄.
|
29494494 |
2018 |