|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Altered expression of norepinephrine transporter participate in hypertension and depression through regulated TNF-α and IL-6.
|
30957546 |
2020 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition, NR decreased the number of activated microglia in the hippocampus, and it reduced the levels of pro-inflammatory (IL-1β, IL-6, and TNF-α) and anti-inflammatory (IL-10 and TGF-β) cytokines in the brain of mice with alcohol-induced depression.
|
31820774 |
2020 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our studies demonstrated that CGA pretreatment ameliorated depression-like behavior (SPT, FST, TST, and OFT) and serum biochemical levels (5-HT, DA, IL-6, and TNF-α) in ACTH-induced depression rats.
|
31073553 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Stress-related suppression of TNFα predicted drinking severity only in alcohol-dependent individuals with subclinical depression, and suppressed TNFR1 following stress was only seen in individuals with subclinical depression.
|
31736187 |
2019 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results showed that there were different levels of depression in patients with ovarian cancer in II~III stage, and the degree of depression could stimulate the level of serum-6, and TNF -α in serum increased.
|
30334417 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
To further elucidate inflammatory mechanisms related to TNF in depression, the aim of the current study was to investigate the involvement of ligands and receptors of the TNF/TNF-receptor-superfamily yet un- or little explored in major depression.
|
31622870 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
Increases in biomarker levels were correlated with reduction in depression severity for TNF-α, IL-6 IL-10 and CRP.
|
31375659 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since depression is a common co-morbid condition with PD, we undertook this study to determine whether Hc-TeTx might also show antidepressant-like properties and whether central brain-derived neurotrophic factor (BDNF) and/or tumor necrosis factor (TNF)-alpha are also affected by it.
|
31125623 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Considering the inflammatory-depression link, and that women are twice as likely to experience depression compared to men, the current study (<i>N</i> = 475 university students) examined the moderating role of three independent cytokine single nucleotide polymorphisms (SNPs; IL-1β rs16944, IL-6 rs1800795 SNP, TNF-α rs1800629) in the relationship between early-life adversity and depressive symptoms, and whether these relations differed between males and females.
|
30967802 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest a complex role for TNF-based neuroinflammation in SCI-induced depression that needs to be further explored, perhaps in conjunction with a broader targeting of additional post-SCI inflammatory cytokines.
|
31064292 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
The biological link between depression, inflammation, and CVD can be related to high levels of pro-inflammatory cytokines, such as IL-1β, TNF-α, and IL-6, released by macrophages which play a central role in the pathophysiology of both depression and CVD.
|
31296155 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results suggest that TNF-α-induced microglial activation has a major role in neuroinflammation of SLE with depression.
|
30572037 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
T2DM HF patients had higher circulating levels of interleukin-6 (IL-6) (P < .01), tumor necrosis factor-alpha (P < .01), and soluble ST2 (sST2) (P < .01) and reported more somatic/affective depressive symptoms (Beck Depression Inventory II) (P < .05) but not cognitive/affective depressive symptoms (P = .20).
|
31017303 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
We estimated seven regularized Mixed Graphical Models in the Netherlands Study of Depression and Anxiety (NESDA) data (N = 2321) to explore shared variances among (1) depression severity, modeled via depression sum-score, nine DSM-5 symptoms, or 28 individual depressive symptoms; (2) inflammatory markers C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α); (3) before and after adjusting for sex, age, body mass index (BMI), exercise, smoking, alcohol, and chronic diseases.
|
31615595 |
2019 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
BDNF levels were negatively correlated and IL-1β and TNF-α levels were positively correlated with Hamilton Depression Rating Scale-24 scores.
|
30616482 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review outlines the immunological mechanism of T1D and depression, with a particular emphasis on the role of tumor necrosis factor-<i>α</i> (TNF-<i>α</i>), IL-1<i>β</i>, and interferon-<i>γ</i> (IFN-<i>γ</i>) cytokines and their signaling pathways.
|
31049023 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
We assessed trauma exposure, PTSD and depression severity, and quantified a panel of pro- inflammatory cytokines, including interleukin (IL)-1β, IL-2, IL-6, IL-8, tumor necrosis factor alpha (TNF-α), interferon ϒ (IFN<sub>ϒ</sub>), and anti-inflammatory cytokines, including IL-4, IL-10 and IL-13 with enzyme-linked immunosorbent assays.
|
30711869 |
2019 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Several behavior tests (sucrose preference test (SPT), forced swimming test (FST) and tail suspension test (TST)) and biochemical parameters (IL-6, TNF-α and SOD levels) were used to evaluate the antidepressive effect of PF on LPS-induced depression model.
|
31052597 |
2019 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The finding that FLX improved depressive behavior and pain through normalized 5-HT concentrations and TNF-α mRNA expression establishes the initial mechanism of the comorbidity of pain and depression.
|
31616368 |
2019 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
According to the current literature, it seems that peripheral levels of interleukin (IL)-6, IL-10, IL-12, IL-13, and tumor necrosis factor (TNF)-α are elevated and that interferon (IFN)-γ levels are lower in patients with depression compared to healthy controls.
|
30792669 |
2019 |
|
Mental Depression
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To gain rich and valid information at the symptom level, this article developed a depression test under the framework of cognitive diagnosis models (CDMs), referred to as CDMs-D. A total of 1,181 individuals were finally recruited and their responses were used to examine the psychometric properties of CDMs-D. After excluding poor items for statistical reasons (e.g., low discrimination, poor model-fit or having DIF), 56 items were included in the CDMs-D.
|
31214095 |
2019 |
|
Mental Depression
|
0.400 |
Biomarker
|
disease |
BEFREE |
We undertook this study to determine whether MOX would actually show antidepressant-like properties in an animal model of depression and whether it would affect the hippocampal and frontal cortex levels of brain-derived neurotrophic factor (BDNF) or tumor necrosis factor (TNF)-alpha, peptides that have been implicated in pathogenesis of depression and effectiveness of various antidepressants.
|
31513828 |
2019 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
1 L-1β, TNF-α and COX-2), increased BDNF expression and neurogenesis, restored the dysfunction of ATP production and oxidative stress in inflammation- induced depression.
|
31022424 |
2019 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
There was a significant difference in the TNF-α levels between the subjects with and without restless legs symptoms in the depression group (p < .001) and among the patients with depressive symptoms but no a depression diagnosis (p = .022).
|
30470307 |
2018 |
|
Mental Depression
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Indeed, depression is associated with increased expression of interferon-γ, interleukin-1β, and tumor necrosis factor α (TNF-α).
|
29543650 |
2018 |