|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate the effects of etanercept on the expression of Fas, tumor necrosis factor-alpha (TNF-α) and caspase-8 in the early stage of the apoptotic pathway in diabetic rats, and to explore the therapeutic effect of etanercept on diabetic retinopathy.
|
31341796 |
2019 |
|
Diabetic Retinopathy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, aflibercept significantly decreased (p < 0.05) the expression of TNF-α in an in vitro and in vivo model of DR.
|
31351870 |
2019 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to evaluate the effectiveness of a connexin43 hemichannel blocker (Peptide5) in a mouse model of DR in which pro-inflammatory cytokines, IL-1β and TNF-α, were intravitreally injected into non-obese diabetic (NOD, hyperglycaemic) mice.
|
30535867 |
2019 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hence, inhibition of TNFα mediated changes can benefit the management of DR and NV-AMD.
|
29678603 |
2018 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Levels of Inflammatory Cytokines IL-1<i>β</i>, IL-6, IL-8, IL-17A, and TNF-<i>α</i> in Aqueous Humour of Patients with Diabetic Retinopathy.
|
29850610 |
2018 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
T2DM: Type 2 Diabetes Mellitus; HbA<sub>1C</sub>: Hemoglobin A<sub>1c</sub>; OHA: Oral Hypoglycemic Agents; STIT: Short-term Insulin Treatment; CSII: Continuous Subcutaneous Insulin Infusion; MDI: Multiple Daily Injections; PPG: Postprandial Plasma Glucose; FPG: Fasting Plasma Glucose; HOMA-b: Homeostasis Model Assessment of beta-cell function; TDD: Total Daily Insulin Dose; DI: Disposition Index; HOMA-IR: Homeostasis Model Assessment of Insulin Resistance; ROS: Reactive Oxygen Species; TNF: Tumor Necrosis Factor; GLP-1: Glucagon-like peptide-1; GIP: Glucose-dependent Insulinotropic Polypeptide; BMI: Body Mass Index; CV: Cardiovascular; DR: Diabetic Retinopathy; SU: Sulfonylurea; IGI: Insulinogenic Index.
|
30244600 |
2018 |
|
Diabetic Retinopathy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In streptozotocin (STZ)-induced DR rats, TPP (0.4 g/kg) treatment restored electrophysiology indexes and retinal ultrastructures, reduced serum IL-6 and TNF-α levels, decreased VEGF and bFGF expression in retinal tissues, and improved haemorheology indexes.
|
29802904 |
2018 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results this meta-analysis indicated that the level of TNF-α in DR patients was significantly different from that in the healthy controls, so TNF-α represents a candidate biomarker for DR.
|
29959897 |
2018 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Univariate analysis showed that male sex, any cardiovascular event, and HbA1c were positively associated with DR, while IL-1RA, IL-1b, IL-6, and TNF-α were significantly negatively associated with presence of DR in the cohort.
|
28556866 |
2017 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The role of cytokines in diabetic retinopathy (DR) and effects of fenofibrate on cytokines were explored by observing changes in serum IL-1β, TNF-α, VEGF, and Lp-PLA2 in different stages of DR and the intervention effect of oral fenofibrate on cytokines.In total, 190 patients with type 2 DR were enrolled and divided into 3 groups: diabetic without retinopathy (NDR) group (n = 30), nonproliferative diabetic retinopathy (NPDR) group (n = 80), and proliferative diabetic retinopathy (PDR) group (n = 80).
|
28767589 |
2017 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1β, IL-6 and TNF-α) in retinal tissues are likely involved in the development of diabetic retinopathy (DR).
|
27288252 |
2017 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Naringin exhibited anti-inflammatory and antioxidative effects as confirmed by the down-regulated pro-inflammatory cytokines, tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6), and the up-regulated antioxidants, glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) in DR rats.
|
28852447 |
2017 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Rats with DR exhibited a significant increase in BRB breakdown, retinal apoptosis, and tumor necrosis factor‑α (TNF‑α) and nuclear factor‑κB (NF‑κB) expression.
|
28138697 |
2017 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus present study concludes that root extract of AT effectively manages the diabetic retinopathy by controlling the blood glucose and also by attenuating the altered oxidative stresss and inflammatory mediators such as TNFα, IL10 and NF-κB in the retina of STZ induced diabetic rat.
|
28262614 |
2017 |
|
Diabetic Retinopathy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-6, IL-8, Inducible Protein-10 (IP-10), leukemia inhibitory factor (LIF), hepatocyte growth factor (HGF) and vascular endothelial growth factor (VEGF)-A were significantly higher (p < 0.05) in the aqueous humor of the DR patients compared to the non-diabetic patients, while the concentrations of IL-1α, IL-4, IL-9, IL-21, IL-23, IL-27, IL-31, RANTES, interferon-α, growth regulated oncogene (GRO), and tumor necrosis factor (TNF)-α were significantly lower (p < 0.05) in the DR patients.
|
28969616 |
2017 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
And the secretion of pro-inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, IL-18 and IL-12, was highly reduced by TLR7-deficiency in DR mice.
|
28843858 |
2017 |
|
Diabetic Retinopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association was found between two promoter variants of TNF and LTA, and diabetic retinopathy in a large cohort of Caucasian patients with type 1 diabetes and type 2 diabetes.
|
26821796 |
2016 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD40 and TNF-α are also central to the development of diabetic retinopathy while CX3CL1 may play a role in the pathogenesis of this retinopathy.
|
26710229 |
2015 |
|
Diabetic Retinopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a case-control study, the -238G>A (rs361525), -308G>A (rs1800629), and -857C>T (rs1799724) polymorphisms of the TNF gene were genotyped in 745 outpatients with type 2 diabetes, including 331 subjects without DR, 246 with nonproliferative DR (NPDR), and 168 with proliferative DR (PDR).
|
25634985 |
2015 |
|
Diabetic Retinopathy
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical staining was used to determine changes in VEGI and vascular endothelial growth factor, interleukin-4, and tumor necrosis factor α levels in rats with diabetic retinopathy.
|
26125742 |
2015 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
BEFREE |
For these studies, primary human retinal endothelial cells (REC) were used since these cells undergo TNFα-mediated apoptosis under conditions of high glucose conditions and contribute to diabetic retinopathy.
|
25073020 |
2014 |
|
Diabetic Retinopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results showed no evidence for significant association between TNF 238 G/A polymorphism and T1DM (for AA + GA versus GG: OR = 0.95, 95% CI = 0.48-1.88, p = 0.89), and also no association between TNF 308 G/A polymorphism and DR and DN risk in T2DM (for AA + GA versus GG: OR = 1.04, 95% CI = 0.87-1.25, p = 0.68; OR = 0.88, 95% CI = 0.71-1.08, p = 0.21; respectively).
|
24073796 |
2014 |
|
Diabetic Retinopathy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study aims to examine the association of tumor necrosis factor-α (TNF-α) g.-308 G > A and adiponectin (ADIPOQ) g. + 45 T > G gene polymorphisms in type 2 diabetes (T2D) and its microvascular complications diabetic retinopathy (DR) and diabetic nephropathy (DN).
|
24655058 |
2014 |
|
Diabetic Retinopathy
|
0.100 |
Biomarker
|
disease |
LHGDN |
The results of the current study suggest that there is a relationship between VEGF, TNF-alpha, IL-6 and the development of the diabetic retinopathy in children with diabetes mellitus type 1.
|
17716775 |
2008 |
|
Diabetic Retinopathy
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
No association found between the promoter variants of TNF-alpha and diabetic retinopathy in Chinese patients with type 2 diabetes.
|
18398712 |
2008 |