|
Fibrosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we report that Gd@C<sub>82</sub>(OH)<sub>22</sub> promote the binding activity of tumor necrosis factor (TNFα) to tumor necrosis factor receptors 2 (TNFR2), activate TNFR2/p38 MAPK signaling pathway to increase cellular collagen expression in fibrosarcoma cells and human primary lung cancer associated fibroblasts isolated from patients.
|
29080421 |
2018 |
|
Fibrosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As in humans, knockdown of receptor-interacting kinase-3 (RIPK3) or mixed lineage kinase domain like (MLKL) blocks TNF-induced necroptosis in L929 fibrosarcoma cells.
|
24434512 |
2014 |
|
Fibrosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, anti-TNF activity was observed in inhibiting TNFalpha-mediated cytotoxicity in the murine L929 fibrosarcoma assay.
|
18547669 |
2008 |
|
Fibrosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The muteins were prepared as a soluble form by using a chaperonin co-expression system and the cytotoxic activities of the purified muteins were evaluated on TNF-sensitive murine fibrosarcoma L929 cells.
|
15703873 |
2005 |
|
Fibrosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Secretion of human soluble tumor necrosis factor receptor type I (sTNFRI) by the mouse fibrosarcoma cell line, L929, previously has been demonstrated to confer resistance to in vitro lysis by TNF and to LAK- and CTL-mediated cytolysis.
|
10753499 |
2000 |
|
Fibrosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to characterize the relative cytotoxic activity of TNF-alpha and TNF mutants on the mouse fibrosarcoma L929 cells in a standard cytotoxicity test, on human larynx carcinoma HEp-2 cells, and on human monoblastoid leukemic cells U937.
|
9892984 |
1999 |
|
Fibrosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we present evidence that HPV-16 E6 sensitized murine fibrosarcoma L929 cells to tumor necrosis factor alpha (TNF)-induced cytolysis.
|
10455154 |
1999 |
|
Fibrosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the therapeutically effective dose of F4614 to MethA fibrosarcoma-transplanted mice was increased compared with that of TNF-alpha, indicating a wide therapeutic index.
|
8528939 |
1995 |
|
Fibrosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF biological activity was tested against the TNF-susceptible fibrosarcoma WEHI 164 clone 13.(ABSTRACT TRUNCATED AT 250 WORDS)
|
1450672 |
1992 |
|
Fibrosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In contrast, a mutein of TNF-alpha, designated as F4236, having the cell-adhesive sequence (Tyr-Ile-Gly-Ser-Arg) at the N-terminus of the TNF molecule did not enhance metastasis, but rather exhibited similar antitumor activity to wild-type TNF-alpha in fibrosarcoma-bearing mice.
|
1617834 |
1992 |
|
Fibrosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Transfection of a human fibrosarcoma cell line with chloramphenicol acetyltransferase expression plasmids linked to a 5'-flanking deletion mutants of the IL-8 gene demonstrated that the nucleotides between -94 and -71 base pairs from the start of the first exon are essential and sufficient for the IL-8 induction by either IL-1, TNF, or phorbol 12-myristate 13-acetate.
|
2250017 |
1990 |
|
Fibrosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have identified a tumor-derived mediator which enhances endothelial procoagulant activity and the cellular response to TNF using cultured cells derived from a murine methylcholanthrene A (meth A)-induced fibrosarcoma as a model system.
|
2324115 |
1990 |
|
Fibrosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Induction and stimulation of 92-kDa gelatinase/type IV collagenase production in osteosarcoma and fibrosarcoma cell lines by tumor necrosis factor alpha.
|
2169729 |
1990 |
|
Fibrosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Human rTNF/Cachectin was shown to stimulate gene transcription of plasminogen activator inhibitor (PA1)-1 and PAI-2, and simultaneously suppress constitutive gene expression of tissue-type plasminogen activator (t-PA) in human fibrosarcoma cells.
|
3137305 |
1988 |