TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 GeneticVariation disease BEFREE Thus present study aimed to analyze the association of TNF-α promoter region alterations (c.-238G>A (rs361525), c.-308G>A (rs1800629), c.-857C>T (rs1799724) and c.-863C>A (rs1800630)) with glaucoma in north Indian cohort. 31132515 2019
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 Biomarker disease BEFREE <b>Abbreviations</b>: BCVA: best corrected visual acuity; BMI: body mass index; CDR: cup-to-disc ratio; EDTA: ethylenediaminetetraacetic acid; ELISA: enzyme-linked immunosorbent assay; ESR: erythrocyte sedimentation rate; HVF: Humphrey visual field; IOP: intraocular pressure; KPro G: keratoprosthesis with glaucoma; KPro NoG: keratoprosthesis without glaucoma; KPro: keratoprosthesis; MD: mean deviation; NA: narrow angle; non-KPro: without keratoprosthesis; PACG: primary angle closure glaucoma; RNFL: retinal nerve fiber layer; TNF-α: tumor necrosis factor alpha; TNFR1: tumor necrosis factor receptor 1; TNFR2: tumor necrosis factor receptor 2. 30632412 2019
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 Biomarker disease BEFREE Pre-treatment of the glaucoma mice with ASIB leads to inhibition of TNF-α and IL-6 production. 31093481 2019
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 Biomarker disease BEFREE Myricetin effectively prevented IOP elevation in glaucoma-induced rats and decreased inflammatory cytokines (IL-1α, IL-1β, IL-6, Il-8, TNF-α) in the aqueous humor and POAG TM cells of glaucoma-induced rats. 30473883 2018
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 Biomarker disease BEFREE IL-17, IL-6 and TNF-α presented good diagnostic values for glaucoma. 29285128 2017
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 GeneticVariation disease BEFREE The combined results showed that the TNF-α -308G/A gene polymorphism was significantly associated with risks of high-tension glaucoma (A versus G: OR=1.660, 95% CI=1.033-2.667; AA/AG versus GG: OR=1.713, 95% CI=1.10-2.651), but not with normal tension glaucoma or exfoliation glaucoma. 23559847 2013
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 GeneticVariation disease BEFREE The aim of our study was to clarify the effect of the TNF-α -308G/A polymorphism on glaucoma risk. 21701244 2012
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 Biomarker disease RGD Here, using a rat model of glaucoma, we investigated the source of elevated TNF-α and examined whether Etanercept, a TNF-α blocker that is in common clinical use for other indications, is protective against RGC death. 22802951 2012
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 GeneticVariation disease BEFREE Frequency of TNF-α -308 G/A and TNF-α -238 G/A promoter polymorphisms in glaucoma and healthy subjects. 21575121 2012
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 Biomarker disease RGD In rats with glaucoma, the pharmacologic use of TrkC antagonists delayed RGC death and reduced the production of retinal TNF-α. 20574020 2010
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 GeneticVariation disease BEFREE Association of tumor necrosis factor alpha gene polymorphism G-308A with pseudoexfoliative glaucoma in the Pakistani population. 20029655 2009
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 GeneticVariation disease BEFREE Of interest, the distribution of TNFA genotypes was significantly different between patients with primary open-angle glaucoma (p = 0.001) or pseudoexfoliative glaucoma (p = 0.001) and controls, while no difference was found when chronic angle-closure glaucoma patients were compared to controls (p = 0.72). 19556827 2009
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 GeneticVariation disease BEFREE Our results suggest that TNF-alpha-308 G/A genotype is not associated with PEX glaucoma. 18852869 2008
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 AlteredExpression disease LHGDN Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP. 17702576 2007
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 GeneticVariation disease BEFREE Statistical analysis showed a possible interaction between polymorphisms in the OPTN and the TNF-alpha genes that would increase the risk for glaucoma. 15557444 2004
CUI: C0017601
Disease: Glaucoma
Glaucoma
0.300 AlteredExpression disease BEFREE To gain insight into the role of OPTN in the development of glaucoma we studied its expression in response to factors known to be associated with the disease: elevated IOP, tumor necrosis factor-alpha (TNFalpha), and dexamethasone (DEX). 12379221 2002