TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE The results demonstrate that emodin could induce necroptosis in glioma possibly through the activation of the TNF-α/RIP1/RIP3 axis. 30924024 2020
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE Glioma cell proliferation was activated with TNF-α treatment and showed extreme sensitivity to the TNF receptor antagonist. 31691497 2020
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE TNF-α and IL-1β expressions were significantly higher in the meningioma and glioma group in comparison to control group. 31653130 2019
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation disease BEFREE The overall analysis showed that increased circulating interleukin-6 (IL-6) [SMD 0.81 (95% CI: 0.21-1.40; P = .008)], interleukin-8 (IL-8) [SMD 1.01 (95% CI: 0.17-1.84; P = .018)], interleukin-17 (IL-17) [SMD 1.12 (95% CI: 0.26-1.98; P = .011)], tumor necrosis factor-α (TNF-α) [SMD 1.80 (95% CI: 1.03-2.56; P = .000)], transforming growth factor-β (TGF-β) [SMD 10.55 (95% CI: 5.59-15.51; P = .000)], and C-reactive protein (CRP) [SMD 0.95 (95% CI: 0.75-1.15; P = .000)] levels were significantly associated with glioma risk. 31599129 2019
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE TNF-α stimulation further upregulated the expression of NF-κB1, STAT-6 in tandem with Ras-MEK signaling system in U87MG cells, which emphasized the possible involvement of these signaling hubs in the glioma microenvironment. 30839135 2019
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE Both compounds exhibited selective cytotoxicity against human glioma stem cells (GSCs) and induced caspase-3 dependent extrinsic apoptosis by increasing the expression of interleukin 1 (IL-1), tumor necrosis factor (TNF-α), and the cleaved caspase-3, while damaged the unlimited proliferation and self-renewal capacity of GSCs. 29486949 2018
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE The activation of TLR4 by LPS in glioma U251 cells induced the expression of cytokines, including IL-1β, IL-6, IL-8, and TNFα, suggesting the functional expression of TLR4. 30145468 2018
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Peripheral blood from 205 treatment-naïve patients with glioma (GBM = 145; non-GBM = 60) was obtained on the day of surgery to measure (i) circulating T-cells reacting to viral antigens and TAAs, in the presence or absence of cytokine conditioning with IL-2/IL-15/IL-21 or IL-2/IL-7, and (ii) serum cytokine levels (IL-4, IL-5, IL-6, TNF-α, IFN-γ and IL-17A). 30049387 2018
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE IL13Rα2-CAR.CD28.ζ T cells proliferated, produced cytokines (IFNγ, TNF-α), and promoted a phenotypically pro-inflammatory glioma microenvironment by inducing a significant increase in the number of CD4<sup>+</sup> and CD8<sup>+</sup> T cells and CD8α<sup>+</sup> dendritic cells and a decrease in Ly6G<sup>+</sup> myeloid-derived suppressor cells (MDSCs). 29503195 2018
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Expression of TROY (TNFRSF19), a member of the tumor necrosis factor (TNF) receptor family, increases with increasing glial tumor grade and inversely correlates with patient survival. 29117939 2018
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE Injection of IL-22 increased the severity of glioma <i>in vivo</i> and higher expression levels of IL-6, IL-1β and tumor necrosis factor (TNF)-α were detected in the brain using ELISA following IL-22 injection. 28450947 2017
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor (TNF) superfamily, can stimulate glioma cell invasion and survival via binding to fibroblast growth factor-inducible 14 (Fn14) and subsequent activation of the transcription factor NF-κB. 28103571 2017
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE FAT10 expression is highly up-regulated by pro-inflammatory cytokines IFN-γ and TNF-α in all cell types and tissues and it was also found to be up-regulated in many cancer types such as glioma, colorectal, liver or gastric cancer. 27393295 2016
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioma cell invasion through induction of NF-κB-inducing kinase (NIK) and noncanonical NF-κB signaling. 25622756 2015
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has potent antitumor effects in glioma cell lines but has shown little clinical benefit for patients. 26142735 2015
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor superfamily, can stimulate glioma cell invasion via binding to fibroblast growth factor-inducible 14 (Fn14) and subsequent activation of the Rho guanosine triphosphatase family member Rac1. 23975833 2014
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE While this work calls into question previous studies that have used the B-D13 antibody to assess IL13Rα2 expression, it also suggests that TNF may have significant effects on glioma biology by up-regulating VCAM-1. 24787244 2014
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα. 23640457 2013
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE To define novel pathways that regulate susceptibility to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in glioma, we have performed genome-wide expression profiling of microRNAs (miRs). 22964638 2013
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression disease BEFREE The combination effect was evaluated by the level of GFP and TNF expression in a human glioma cell line, and the mechanism of MMC effects on rAAV mediated gene expression was investigated by AAV transduction related signal molecules. 24451124 2013
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) shows a strong apoptosis-inducing effect on a variety of cancer cells including glioma. 23338605 2013
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE This ability of CK2-Is to sensitize glioma to TNFα-induced death via multiple mechanisms involving abrogation of NF-κB activation, reactivation of wild-type p53 function and SIRT1 inhibition warrants investigation. 22318540 2012
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Previous studies have shown that the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has significant apoptosis-inducing activity in some glioma cell lines, although many lines are either moderately or completely resistant, which has limited the therapeutic applicability of this agent. 21220502 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease CTD_human In addition, resveratrol repressed nuclear factor kappa B (NF-κB) activation and down-regulated mRNA expression of urokinase plasminogen activator (uPA) and its receptor in TNF-α-treated glioma cells. 22199285 2011
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker disease BEFREE Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in malignant cells, including gliomas, and is currently in anticancer clinical trials. 21368892 2011