TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE Further, we found that chemically inhibiting or activating AhR reciprocally modulated expression levels of cytokines induced by infection, specifically IL-1β, IL-10, and TNFα, consistent with a role for AhR activation in the host response to MHV infection. 31694960 2020
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE When human colon cancer cells were xenografted into these mice, prophylactic blockade of human TNF improved colitis and hepatitis in xenografted mice, and moreover, immunotherapeutic control of xenografted tumours was retained. 31043740 2019
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE As TLR4 and SPK/S1P signaling pathways play important roles in the progression of liver inflammation, the effect on sphingosine pathway and TLR4 was associated with decreased concentrations of inflammatory markers, enzyme kB kinase (IKK), nuclear factor-kB and tumor necrosis factor-α as compared to untreated NAFL group. 31004566 2019
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 AlteredExpression group BEFREE Liver inflammation was confirmed by increase in the levels of TNF-α and IL-6 in carcinogen treated rats. 30324893 2019
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE As chronic liver inflammation leads to liver fibrosis, IL-17 and/or TNF-α neutralization can be of interest to control liver inflammation and therefore its effects on fibrosis. 31102558 2019
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 AlteredExpression group BEFREE Furthermore, global T-cells from the ENEG phase displayed a proinflammatory cytokine profile with upregulated IFN-γ and TNF-α expression, while this profile was suppressed in IT and IA patients. 31086463 2019
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE Galectin-3 Deficiency Facilitates TNF-α-Dependent Hepatocyte Death and Liver Inflammation in MCMV Infection. 30800112 2019
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE Hence, Fn restrains HFD-induced hepatic inflammation and lipid deposition by downregulating metabolic disorder and excessive liver inflammation-associated TNF-α/RIPK3 axis activation. 30793717 2019
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE PUFAs, PGE1, lipoxins, resolvins, protectins, and maresins suppress TNF-α and other pro-inflammatory cytokines, exert cytoprotective effects, and modulate stem cell proliferation and differentiation to promote recovery following hepatitis, NAFLD and AFLD. 31193303 2019
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 AlteredExpression group BEFREE RA can protect against ConA-induced hepatitis through: interrupting early inflammatory response as neutrophils, monocytes and CD4+ T cells infiltration, modulating IL-4 level and subsequent production of TNF-α and NF-κb activation, mitigating second inflammatory responses through increasing IL-10 liver production. 31419710 2019
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE Conclusion: Our study uncovers key roles for TNF and, to a lesser extent, IL-17 as mediators of liver inflammation and fibrosis induced by constitutive NLRP3 inflammasome activation in myeloid-derived cells. 28902427 2018
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 AlteredExpression group BEFREE The Ldlr<sup>-/-</sup> mice fed the high-fat/high-cholesterol diet showed liver inflammation, as reflected by increased (3- to 4-fold) infiltration of inflammatory cells and increased (3- to 4-fold) gene expression of tumor necrosis factor α, integrin αM, intracellular adhesion molecule, and vascular cell adhesion molecule. 28990215 2018
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE Mouse MSCs (mMSCs) significantly reduced Con A- and α-GalCer-mediated hepatitis in C57Bl/6 mice, as demonstrated by histopathological and biochemical analysis, attenuated the influx of inflammatory [T-bet<sup>+</sup> , tumour necrosis factor-α (TNF-α), interferon-γ (IFN-γ)-producing and GATA3<sup>+</sup> , interleukin-4 (IL-4)-producing] liver NKT cells and downregulated TNF-α, IFN-γ and IL-4 levels in the sera. 28488390 2018
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE Among 783 patients treated with anti-TNF (n = 472) or DMARDs only (n = 311), HBsAg-/HBcAb+ anti-TNF users had incidence of ALT elevation commensurate with uninfected counterparts (6.1 vs. 6.0/100 person-years), compared to 19.6/100 person-years in HBsAg+ patients (standardized rate ratio 3.3, 95% CI 1.3-8.2); none effected had severe or fatal hepatitis and ALT levels in all HBsAg-/HBcAb+ patients remained stable, mostly normalizing spontaneously, or after moderating treatment. 29694398 2018
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE Genetic ablation of TNF receptor type I (TNFR) in Tak1ΔHep mice remarkably reduced liver inflammation-fibrosis-cancer axis. 28875549 2018
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 AlteredExpression group BEFREE Further research demonstrated that Rg1 suppressed liver inflammation response through repressing the expression levels of inflammation-related genes including TNF-α, IL-1β, IL-6, COX-2, and iNOS. 29964319 2018
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 AlteredExpression group BEFREE The lipid accumulation induced by the HFD was not associated with liver inflammation; however, MET seemed to promote pro-inflammatory effects in liver, since it increased hepatic concentration of IL-1β, TNF-α, IL-6, MCP-1 and IFN-γ. 29450671 2018
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE Although it is well established that TNFα contributes to hepatitis, liver failure and associated hepatocarcinogenesis via the regulation of inflammation, its pro-apoptotic role in the liver has remained enigmatic. 30185788 2018
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE Interestingly, while TRAIL administration did not induce hepatitis in Ripk1 <sup>LPC-KO</sup> mice or in their WT counterparts, its combination with IFN-γ only induced TNF-α dependent apoptosis in the Ripk1 <sup>LPC-KO</sup> mice. 28835677 2017
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 AlteredExpression group BEFREE There was no histological evidence for liver inflammation after PN administration, and circulating levels of pro-inflammatory cytokines IL-6 and TNF-α, were comparable in all groups. 28029505 2017
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE TNF-α and TGF-β were associated with hepatitis severity (p = 0.0409, p = 0.0321). 29038590 2017
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE The production of TNF and FasL indicated that they are the pivotal effectors in this hepatitis. 27708340 2016
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 Biomarker group BEFREE TNF-α deficiency attenuated hepatitis in HFHCD-fed mice. 26608915 2016
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 GeneticVariation group BEFREE The stepwise logistic regression analysis showed that the TNFα genotypes (GA + AA) were significantly associated with liver inflammation (OR = 3.776, 95%CI: 1.399-10.194, P = 0.009), severe steatosis (OR = 4.49, 95%CI: 1.441-14.0, P = 0.010) and fibrosis progression (OR = 2.84, 95%CI: 1.080-7.472, P = 0.034). 27678360 2016
CUI: C0019158
Disease: Hepatitis
Hepatitis
0.100 AlteredExpression group BEFREE Serum levels of interleukin 8, chemokine (C-C motif) ligand 3, and tumor necrosis factor-α correlated with liver inflammation and NAFLD activity score. 26028579 2015