Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
HCV infection of thyrocytes induced the production of the chemokine CXCL-8 and the pro-inflammatory cytokines TNFα and significantly increased the expression of miR-122.
|
31784757 |
2020 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
HCV infection was accompanied by a significant increase in TNFα plasma levels.
|
31221551 |
2019 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
To describe and quantify the incidence and morbidity of hepatitis B reactivation (HBVr) secondary to pharmaceutical agents (eg, rituximab, tumor necrosis factor inhibitors, direct-acting antivirals [DAAs] for hepatitis C) among patients with previously resolved hepatitis B infection.
|
30203666 |
2019 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
TLR9 activation of AtMs induces a specific transcriptional signature centred on TNFα overexpression, and an enhanced secretion of TNFα and rheumatoid factor-type IgMs in patients with HCV-CV.
|
31279905 |
2019 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Together, these findings identify a molecular mechanism by which HCV-p7 induces SOCS3 through STAT3 and ERK activation and demonstrate that p7 suppresses proinflammatory responses to TNF-α, possibly explaining the lack of inflammatory symptoms observed during early HCV infection.-Convery, O., Gargan, S., Kickham, M., Schroder, M., O'Farrelly, C., Stevenson, N. J.
|
31163989 |
2019 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased tumour necrosis factor (TNF)-α production induced by HBV and HCV leads to a polyunsaturated fatty acid (PUFA) deficiency and hypoalbuminemia.
|
31193303 |
2019 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study examined the role of both (-964 A/G) single-nucleotide polymorphism (SNP) of IL-27p28 rs153109 and (-308 G/A) SNP of TNF-α rs1800629 on the progression of HCV infection in genotype 4a infected patients.
|
30204505 |
2019 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF-α is a key cytokine for both hepatitis C progression and psoriasis.
|
30398009 |
2018 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Study highlighted that, A allele was significantly associated with (p < .05) spontaneous clearance of HCV infection and G allele was correlated with viral persistence at TNF-α (-308) gene polymorphism.
|
29196132 |
2018 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hepatitis C virus (HCV)‑infected liver cells sensitize host cells to tumor necrosis factor (TNF)‑related apoptosis‑inducing ligand (TRAIL)‑induced cell apoptosis; however, the precise mechanisms are unknown.
|
29620268 |
2018 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Nonetheless, these results corroborate evidence for elevations in IP-10 and TNFα in HIV and for IP-10 levels in HIV+HCV co-infection.
|
29408932 |
2018 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, results of plasma total mRNAs after δ-tocotrienol feeding to hepatitis C patients revealed significant inhibition in the expression of pro-inflammatory cytokines (TNF-α, VCAM1, proteasome subunits) and induction in the expression of ICAM1 and IFN-γ after post-treatment.
|
30031388 |
2018 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL1β, IL6 and TNFα were factors that induced MCP-1 expression, which were up-regulated in macrophages induced by HCV.
|
28860098 |
2017 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Macrophage Activation and the Tumor Necrosis Factor Cascade in Hepatitis C Disease Progression Among HIV-Infected Women Participating in the Women's Interagency HIV Study.
|
29077674 |
2017 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF superfamily members promote hepatitis C virus entry via an NF-κB and myosin light chain kinase dependent pathway.
|
27983476 |
2017 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combined unfavorable TNFα (GA/AA) and TGFβ1 (CT/TT) genotypes were highly associated with abnormal liver function parameters and were significantly higher in high activity (A2-A3) and late fibrosis (F2-F4) HCV patients (p = 0.023, 0.029).
|
28151059 |
2017 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
HCV-specific CD8 T-cell activation (CD107a, gamma interferon, macrophage inflammatory protein 1β, tumor necrosis factor alpha) was dependent on the peptide concentrations and the relative percentages of HCV-infected Huh7.5A2 cells.
|
28275182 |
2017 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously shown that culture-derived HCV (HCVcc) enhance tumor necrosis-factor-related apoptosis-inducing ligand (TRAIL) expression on healthy NK cells, but not on those from patients infected with HCV, which was likely dependent on accessory cells.
|
28803951 |
2017 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Preceding the uptake, PBMCs caused apoptosis of HCV SGR cells by tumor necrosis factor-related apoptosis inducing ligand (TRAIL) expression on NK cells.
|
29085359 |
2017 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF inhibited completion of the HCV infectious cycle in hepatoma cells and HFLCs in a dose-dependent and time-dependent manner.
|
28456632 |
2017 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present study, we aimed to estimate the concentrations of cytokines (interleukin 6, IL-6, tumor necrosis factor-α, TNF-α) and auto-antibodies (rheumatoid factor IgM isotype, IgM-RF, antinuclear auto-antibodies, ANA, anti-cyclic citrullinated peptide antibodies IgG isotype, IgG anti-CCP3.1, anti-cardiolipin IgG isotype, IgG anti-aCL) in serum of patients with eRA (early rheumatoid arthritis) and HCVrA (hepatitis C virus-related arthropathy) and to assess the utility of IL-6, TNF-α together with IgG anti-CCP and IgM-RF in distinguishing between patients with true eRA and HCVrA, in the idea of using them as differential immunomarkers.
|
28629188 |
2017 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further, we used the developed method to construct a mosaic gene regulatory network including hepatitis C virus (HCV) as the first piece and the tumour necrosis factor (TNF)-induced apoptosis and NF-κB induction pathways as the second piece.
|
26481968 |
2016 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Peripheral blood monocyte surface marker (CD14, CD16, CD163, CSF1R, CCR2, CCR4, CCR5, CXCR3, CXCR4, CX3CR1, HLA-DR, CD62L, SIGLEC-1) expression and capacity for phagocytosis, oxidative burst and LPS-stimulated TNF production were assessed in patients with hepatitis C (HCV) (n = 39) or non-alcoholic fatty liver disease (NAFLD) (n = 34) (classified as non-advanced disease, compensated cirrhosis and decompensated cirrhosis) and healthy controls (n = 11) by flow cytometry.
|
27309850 |
2016 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the association between polymorphisms in TNF-α -308 G>A (rs1800629), IL-10 -1082 G>A (rs1800896) and -819/-592 (rs1800871/rs1800872) with HCC risk in individuals with HCV.
|
26890368 |
2016 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Current data showed that the TNFα -G308A SNP frequency was significantly different between controls and HCV infected patients (P = 0.001).
|
27678360 |
2016 |