|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Gingival bleeding index (GI), probing depth (PD), clinical attachment level (CAL), number of teeth, CD4+ T lymphocytes and viral load (only for HIV-infected individuals), salivary cytokines (interleukin, [IL]-6, IL-8, and tumoral necrosis factor-alpha [TNF-α]), and oral Candida infection (colony forming units and species) were assessed at baseline, and 30 and 90 days after NSPT.
|
30118537 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Dorsal and DIF act downstream of the Toll pathway, whereas Relish acts in the IMD pathway.
|
30735676 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
A statistically significant decrease in CSF TNFα over time (p < .0001) was only detectable with the MBA platform, and TNFα on the MBA was the only CSF biomarker to correlate with CSF HIV RNA (rho = 0.71, p < .0001).
|
30468733 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lack of T-cell-mediated IL-2 and TNFα production is linked to decreased CD58 expression in intestinal tissue during acute simian immunodeficiency virus infection.
|
30480508 |
2019 |
|
Immunologic Deficiency Syndromes
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tissue immunofluorescence showed higher proportions of CD4+ and CD68+ (monocyte/macrophage) cells expressed TNF during IRIS compared with HIV-uninfected patients.
|
29538651 |
2018 |
|
Immunologic Deficiency Syndromes
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Comparatively, upon injecting mice with EBV DNA, we detected enhanced expression of tumor necrosis factor-α (TNFα); this enhancement is rather comparable to IMD pathway activation in flies.This study hence indicates that <i>D. melanogaster</i> could possibly be utilized to identify immune mediators that may also play a role in the response to EBV DNA in higher systems.
|
29942298 |
2018 |
|
Immunologic Deficiency Syndromes
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The mean level of IL-10, INF-gamma and TNF-α were higher in HIV infected individuals with low CD4 counts (<300 cells/μl).
|
26776123 |
2016 |
|
Immunologic Deficiency Syndromes
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In a cross-sectional study of 61 HIV-1 infected individuals categorized according to disease progression as having non-progressive HIV-1 infection (n=14) and progressive infection (n=47), plasma levels of active TGF β 1, INF-γ, TNF-α, IL-10, IL-1β, IL-12p70 and IL-13 were compared with HIV uninfected healthy controls (n=12).
|
26986868 |
2016 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumour suppressing effect of AT-MSC/hTNFα on A375 melanoma xenografts was monitored in an immunodeficient mouse model in vivo.
|
25677845 |
2015 |
|
Immunologic Deficiency Syndromes
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mutations in the TNF family of proteins have been associated with inherited forms of immune deficiency.
|
23493554 |
2013 |
|
Immunologic Deficiency Syndromes
|
0.100 |
GeneticVariation
|
group |
BEFREE |
However, application of Bonferroni correction identified only two SNPs i.e., TNF-α -238 AG and IL-4 -33 TT to be significantly associated with the acquisition of HIV.
|
23867674 |
2013 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Supporting a role for regulation of innate responses in parasite development, we show that regulation of inflammation by neutralizing anti-TNF antibodies also restores parasite development in immunodeficient mice.
|
24130499 |
2013 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Simian immunodeficiency virus-induced alterations in monocyte production of tumor necrosis factor alpha contribute to reduced immune activation in sooty mangabeys.
|
22553338 |
2012 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
However, the functionality of HIV-specific CD8(+) T-cell populations upon antigen encounter, determined by the simultaneous and independent measurement of five CD8(+) T-cell functions (degranulation and gamma interferon, macrophage inflammatory protein 1beta, tumor necrosis factor alpha, and interleukin-2 levels) reflected the emergent level of plasma virus, with multiple functions being elicited in those individuals with lower levels of viremia after SIT.
|
18234797 |
2008 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation.
|
16379012 |
2006 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
The growth of the transformed tumors was compromised in both immunosuppressed and severe combined immunodeficient mice; no signs of TNF toxicity were detected.
|
12860289 |
2003 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin-7, reported to be a crucial cofactor of tumor necrosis factor (TNF) to promote HIV replication, is shown here to counteract the apoptotic activity of TNF.
|
11568004 |
2001 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that TNF-alpha could modulate HIV and brain tumor pathogenesis and immune-mediated inflammation in the central nervous system (CNS) by regulation of CXCR4 expression.
|
11146046 |
2001 |
|
Immunologic Deficiency Syndromes
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, treatment of TH4-7-5 cells with TNF-alpha or IL-1beta stimulated RNA and protein secretion of IL-8, MCP-1, and RANTES as well as HIV expression.
|
10786999 |
2000 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
TNF was capable of triggering undiminished primary demyelination in all of the immunodeficient mice, in the presence of activated cells of the macrophage/microglial lineage.
|
10092095 |
1999 |
|
Immunologic Deficiency Syndromes
|
0.100 |
Biomarker
|
group |
BEFREE |
Differential tumor necrosis factor alpha production in simian immunodeficiency virus-infected rhesus macaques coinfected with Mycobacterium avium.
|
10194069 |
1999 |
|
Immunologic Deficiency Syndromes
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Levels of tumor necrosis factor-alpha messenger RNA were significantly higher and levels of interleukin (IL)-4 messenger RNA were significantly lower in demented compared to nondemented HIV-infected patients.
|
8498837 |
1993 |