TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Therapeutic phenotype RGD The results showed that intraplantar injection of carrageenan led to time-dependent development of peripheral inflammation, which resulted in a significant increase in the levels of tumor necrosis factor α (TNF-α) and interleukin 1 (IL-1) β, nitric oxide (NO) and prostaglandin E2 (PGE2) and also iNOS and COX-2 protein expression in inflamed paw. 26069367 2016
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Therapeutic phenotype RGD The galactose-binding lectin isolated from Bauhinia bauhinioides Mart seeds inhibits neutrophil rolling and adhesion via primary cytokines. 25706245 2015
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human Cerebroprotective potential of resveratrol through anti-oxidant and anti-inflammatory mechanisms in rats. 23371441 2013
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human Citronellal, a monoterpene present in Java citronella oil, attenuates mechanical nociception response in mice. 23795810 2013
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human Anti-inflammatory activity of patchouli alcohol in RAW264.7 and HT-29 cells. 23348408 2013
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human Quercetin attenuates TNF-induced inflammation in hepatic cells by inhibiting the NF-κB pathway. 22452660 2012
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human Changes in expression of hepatic cytochrome P450 subfamily enzymes during development of adjuvant-induced arthritis in rats. 21467745 2011
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human UDCA-LPE inhibited TNFα-induced apoptosis and inflammation in hepatocytes in vitro and markedly ameliorated GalN/LPS-mediated fulminant hepatitis in mice, whereas UDCA or PC failed to show protection. 21146893 2011
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human The aim of this study was to examine the extent to which quercetin and trans-RSV prevented inflammation or insulin resistance in primary cultures of human adipocytes treated with tumor necrosis factor-α (TNF-α)-an inflammatory cytokine elevated in the plasma and adipose tissue of obese, diabetic individuals. 20943792 2010
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice. 19803787 2010
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human Niacin also inhibited intima-media neutrophil recruitment and myeloperoxidase accumulation, enhanced endothelial-dependent vasorelaxation and cyclic guanosine monophosphate production, increased vascular reduced glutathione content, and protected against hypochlorous acid-induced endothelial dysfunction and tumor necrosis factor alpha-induced vascular inflammation. 20167660 2010
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human Anti-inflammatory and antioxidant effects of SERPINA3K in the retina. 19324842 2009
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype LHGDN The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events: Implication in periodontal inflammation. 18543247 2008
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 AlteredExpression phenotype LHGDN Proinflammatory cytokines seem to be only partly involved in the pathophysiology of CRPS1, as indicated by the lack of coherence between TNF-alpha and IL-6 levels and the signs and symptoms of inflammation and disease duration. 18055234 2008
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype LHGDN CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion. 17660390 2007
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype LHGDN Tumor necrosis factor alpha activates release of B lymphocyte stimulator by neutrophils infiltrating the rheumatoid joint. 17530706 2007
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype LHGDN Our results indicate a primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection. 17132473 2006
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human Involvement of tumor necrosis factor-alpha in sulfur mustard-induced skin lesion; effect of topical iodine. 16001271 2005
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human Genetic variation in selenoprotein S influences inflammatory response. 16227999 2005
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human Therapy of ischemic cardiomyopathy with the immunomodulating agent pentoxifylline: results of a randomized study. 14970111 2004
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 AlteredExpression phenotype LHGDN Tumor necrosis factor-alpha is associated with increased protein C activation in nonobese type 2 diabetic patients. 14988320 2004
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype LHGDN These results are in agreement with the hypothesis that the synthesis of adipose tissue TNFalpha and leptin could induce the production of interleukin-6, CRP, and other acute-phase reactants, thus contributing to the maintenance of chronic low-grade inflammation state involved in the progression of obesity and its associated comorbidities. 12690081 2003
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype CTD_human Glucocorticoids play a fundamental role in protecting the brain during innate immune response. 12843254 2003
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype LHGDN Modulation of IL-8 and RANTES release in human conjunctival epithelial cells: primary cells and cell line compared and contrasted. 12792476 2003
CUI: C0021368
Disease: Inflammation
Inflammation
0.600 Biomarker phenotype LHGDN Overall, our results clearly demonstrate that adenosine selectively suppresses TNF-induced NF-kappaB activation, which may contribute to its role in suppression of inflammation and of the immune system. 12606947 2003