|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Five studies in 3316 subjects assessed TNFRs with renal disease in patients with type 1 diabetes and showed both TNFR-1 and TNFR-2 were consistently associated with the renal outcomes.
|
31813103 |
2019 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings highlight the importance of transmembrane TNF in inflammatory kidney disease as a possible therapeutic target.
|
30389199 |
2019 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In summary, our results indicate widespread methylation differences in DKD kidneys and highlights epigenetic changes in the TNF locus and its contribution to the development of nephropathy in patients with diabetes mellitus.
|
31167971 |
2019 |
|
Kidney Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This study aimed to assess the renopreventive effect of enalapril and/or paricalcitol on streptozotocin (STZ) diabetes-induced nephropathy and to elucidate their mechanisms of action through investigation of the effects on renal oxidative stress, antioxidant defense system and expressions of TNF-α, p53, caspase-3, and Bcl-2.
|
31527864 |
2019 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The results suggest that the cytokines IL-1β and TNF-α may increase urinary corin in patients with primary proteinuric kidney diseases.
|
29387201 |
2018 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
uBAFF was detectable in a small but a significant proportion of SLE patients but not in other groups tested, and was higher in SLE patients with active renal disease.
|
30301439 |
2018 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The present study implicates a strong association between cytokine TNF-α, IL-6 and IL-1β gene promoter polymorphisms and modulation of transcript levels with susceptibility to nephropathy in diabetes subjects.
|
29605608 |
2018 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Blockade of TNFα has been shown to be effective in a number of human autoimmune diseases, including rheumatoid arthritis, raising the question of whether this approach may be effective in inflammatory kidney disease, such as ANCA-associated vasculitis (AAV).
|
28391344 |
2017 |
|
Kidney Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor necrosis factor-α (TNFα), is a pathogenic cytokine in kidney disease that alters expression of claudins in tubular cells.
|
27966776 |
2017 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
TNF-α -308G/A+A/A genotypes (p<0.01) and LTα +252 A/G+G/G genotypes (p<0.02) were significantly associated with renal disorders and haematological manifestations.
|
27838362 |
2017 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, the highest concentrations of both Il-6 and TNF-α were observed for patients with the most severe nephropathy.
|
28300543 |
2017 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Because CD40, a member of the tumor necrosis factor receptor family, has been linked to the progression of kidney disease in ischemic nephropathy, we studied the role of Cd40 in the development of hypertensive renal disease.
|
27692815 |
2017 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest that TNF-α plays an important role in the HFD induced kidney damage, and targeting TNF-α and/or its receptors could be a promising therapeutic regimen for progressive nephropathy.
|
28683439 |
2017 |
|
Kidney Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TNF-like weak inducer of apoptosis (TWEAK) receptor Fn14 is expressed by podocytes and Fn14 deficiency protects from experimental proteinuric kidney disease.
|
27353019 |
2016 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The study indicates significance for IL-6 and TNF-α gene with basic kidney diseases and ESRD.
|
26421528 |
2016 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumour necrosis factor-a (TNF-α) is an important cytokine involved in initiation and progression of renal diseases.
|
25589331 |
2015 |
|
Kidney Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Among SLICC SLE patients, MCTD criteria were associated with reduced rates of renal disease (odds ratio (OR) 4.3, 95% confidence interval (CI) 1.3-14.0), increased rates of Raynaud's phenomenon (OR 3.5, 95% CI 1.3-9.5) and increased serum B-cell maturation antigen, transmembrane activator and CAML interactor and TNFα levels.
|
25736140 |
2015 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The TNFA rs1800629 gene polymorphism is associated with markers of kidney disease severity and distant organ dysfunction among patients with AKI.
|
23796916 |
2013 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
TNFα (tumour necrosis factor α) has also been implicated in the pathogenesis of inflammatory kidney diseases, including forms of glomerulonephritis associated with viral diseases.
|
22950839 |
2012 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
TNF-α was essential for acceleration of Alport nephropathy, as etanercept (a soluble TNF-α receptor) entirely abrogated the CpG-DNA effect.
|
20962742 |
2011 |
|
Kidney Diseases
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Association of anemia and erythropoiesis stimulating agents with inflammatory biomarkers in chronic kidney disease.
|
18547996 |
2008 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
LHGDN |
Hyperinsulinemia in pediatric patients with chronic kidney disease: the role of tumor necrosis factor-alpha.
|
17541791 |
2007 |
|
Kidney Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our findings suggest that the GG genotype of TNF-alpha G-308A polymorphism or a genetic variant in close linkage disequilibrium may interact with obesity to increase the risk of nephropathy in Chinese Type 2 diabetic patients.
|
16141456 |
2005 |
|
Kidney Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the patients with RA and amyloidosis, those with nephropathy had significantly higher TNFalpha and sTNFRI levels than did those without nephropathy; in patients with isolated proteinuria (but no creatinine elevation) the TNFalpha level was also significantly increased, indicating that the TNFalpha elevation was not merely a consequence of impaired renal function.
|
14613268 |
2003 |
|
Kidney Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Stratification of patients suggested that DRB*1501 and TNF a11 frequencies were higher in SLE patients with renal disease and TNF a2 and b 3 frequencies in those without, although these differences did not reach statistical significance.
|
9543565 |
1998 |