Leprosy
|
0.100 |
Biomarker
|
disease |
BEFREE |
We analyzed the presence of M4 macrophage markers (CD68, MRP8, MMP7, IL-6, and TNF-α) in 33 leprosy skin lesion samples from 18 patients with tuberculoid leprosy and 15 with lepromatous leprosy by immunohistochemistry.
|
30442123 |
2018 |
Leprosy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Earlier studies have shown that tumor necrosis factor (<i>TNF</i>) -308 G>A (rs1800629) gene polymorphism is implicated in the susceptibility to leprosy, but results were inconsistent.
|
28935761 |
2017 |
Leprosy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The -308 bp G/A single nucleotide polymorphism (SNP rs1800629) in the tumor necrosis factor (TNF) gene promoter is a proposed risk factor for leprosy.
|
26829382 |
2016 |
Leprosy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we evaluated the single nucleotide polymorphisms (SNPs) -238 G/A (rs361525), -308 G/A (rs1800629), -857 C/T (rs1799724), -863 A/C (rs1800630) and -1031 T/C (rs1799964) in the promoter region of the TNF to see whether these SNPs influence host-susceptibility to leprosy and the different clinical manifestation.
|
25636570 |
2015 |
Leprosy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of tumor necrosis factor-alpha and interferon gamma gene polymorphisms and their plasma levels in leprosy, HIV and other peripheral neuropathies.
|
26431782 |
2015 |
Leprosy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interaction analysis between PARK2 and significant SNPs of anti-inflammatory/proinflammatory cytokine genes, including BAT1 to BTNL2-DR spanning the HLA (6p21.3) region in a case-control comparison, showed that the combined analysis of: (1) PARK2, tumour necrosis factor (TNF), BTNL2-DR, interleukin (IL)-10, IL-6 and TGFBR2 increased the risk towards leprosy (OR=2.54); (2) PARK2, BAT1, NFKBIL1, LTA, TNF-LTB, IL12B and IL10RB provided increased protection (OR=0.26) in comparison with their individual contribution.
|
24578538 |
2014 |
Leprosy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum cytokine levels of IP-10, IL-17F, IL-IL-6 and TNF-α are significantly higher (p<0.05) in leprosy cases with T1R when compared the NR leprosy cases.
|
24189521 |
2014 |
Leprosy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pairwise interaction analysis followed by combined analysis of multiple SNPs identified that IL12B, TNF and BTNL2-DRA inter-genic SNPs provided a major risk towards leprosy (p=2.6E-08, OR=3.94 (2.43-6.38)), showing a further increase (p=3.6E-14) for combined risk genotype interactions.
|
23240095 |
2013 |
Leprosy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Nine SNPs located in BAT1, LTA, TNF genes and BTNL2-DRA interval showed strong association with leprosy susceptibility in two independent sets of North Indian population which was replicated in a geographically distinct East Indian population.
|
22071774 |
2012 |
Leprosy
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results reinforce the association between TNF and leprosy and suggest the -308A allele as a marker of disease resistance, especially among Brazilians.
|
21917899 |
2011 |
Leprosy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results confirm previous findings of an association of TNF -308A with protection from leprosy and MBL polymorphisms with protection from lepromatous leprosy.
|
20650301 |
2010 |
Leprosy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Influence of TNF and IL10 gene polymorphisms in the immunopathogenesis of leprosy in the south of Brazil.
|
19058987 |
2009 |
Leprosy
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
When leprosy types were divided, the allele frequency of TNF-308A was significantly increased in multibacillary leprosy compared to the normal controls (p = 0.04, OR = 2.93).
|
17624216 |
2007 |
Leprosy
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study analyzed the changes in mRNA expression and immunodistribution of MMP-2, MMP-9, TNF-alpha-converting enzyme (TACE), TNF-alpha in nerves of 27 pure neuritic leprosy (PNL) patients, both acid-fast bacilli positive (AFB(+)) and acid-fast bacilli negative (AFB(-)), and 8 non-leprosy patients with control peripheral neuropathic conditions.
|
17868246 |
2007 |
Leprosy
|
0.100 |
Biomarker
|
disease |
BEFREE |
The only significant result obtained was linkage of leprosy clinical subtype to the HLA/TNF region on human chromosome 6p21 (P(corrected)=0.00126).
|
12595904 |
2003 |