|
Liver diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Plasma claudin-3 is associated with tumor necrosis factor-alpha-induced intestinal endotoxemia in liver disease.
|
31053499 |
2019 |
|
Liver diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Consistent with the multifactorial etiology of alcohol-associated liver disease, we identified strong combined effects of HPMA and proinflammatory cytokines (IL-1β, IL-8, and TNFα) on the extent/pattern of liver cell death, thereby supporting the pathogenic role of acrolein.
|
30234998 |
2019 |
|
Liver diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The use of probiotics with clinical evidence in liver disease, represent a novel therapeutic alternative, inducing positive changes in the balance of the intestinal microbiota which lead to improvement in liver function tests (AST and ALT), decreasing tumor necrosis factor-α (TNF-α), andblood cholesterol, among other risk factors.
|
29653359 |
2018 |
|
Liver diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Unsupervised analysis of multi-parametric data showed that liver disease was associated with the intrahepatic expansion of activated myeloid cells mainly composed of pro-inflammatory CD14<sup>+</sup>HLA-DR<sup>hi</sup>CD206<sup>+</sup> cells, which spontaneously produced TNFα and GM-CSF.
|
28483682 |
2017 |
|
Liver diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) have been associated with liver disease.
|
28411440 |
2017 |
|
Liver diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The influence of different TNFα -G308A genotypes on TNFα expression and liver disease progression were statistically analyzed.
|
27678360 |
2016 |
|
Liver diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In summary, Misoprostol was effective at beneficially modulating TNF and IL-10 levels both in vivo and in vitro; these studies suggest a potential rationale for Misoprostol use in ALD, NASH and other liver diseases where inflammation plays an etiologic role.
|
26408955 |
2015 |
|
Liver diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
These results identify a new signaling pathway that regulates TNF-α production in LPS-induced liver damage and suggest potential cell-specific therapeutic targets for liver diseases in which TNF-α production is involved.
|
23202732 |
2013 |
|
Liver diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The genotypes TNF-α-308GG - LT-α + 252AA and TNF-α-308GA - LT-α + 252AG were unfavorable with regard to liver disease development (both p < 0.05).
|
23343370 |
2013 |
|
Liver diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Importantly, Fn14 was the only TNF superfamily receptor exclusively upregulated in AH compared with other liver diseases and correlated with both 90-day mortality and severity of portal hypertension.
|
22637703 |
2013 |
|
Liver diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The efficacy of the inhibition of APE1 redox activity in blocking TNF-α and FAs induced inflammatory response opens new perspectives for treatment of inflammatory-based liver diseases.
|
23967134 |
2013 |
|
Liver diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The tumor necrosis factor receptor-associated factor family member-associated nuclear factor-κB (NF-κB) activator (TANK) takes part in the tumor necrosis factor-α (TNF-α)-mediated NF-κB signaling pathway and the interferon (IFN)-induction pathways that have relevance to HBV-related liver disease.
|
22225470 |
2012 |
|
Liver diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Compared with "alcoholic" controls without liver disease (n=110), TNFα -238AA genotype, IL1β -511CC genotype, TGFβ1 -509CC genotype and IL10 -592AA genotype were significantly overrepresented in ALD patients (n=181; OR=2.4 and 95% CI 1.2-5.5, P(genotype)=0.042, P(allelic)=0.008; OR=2.7 and 95% CI 1.2-5.9, P(genotype)=0.018, P(allelic)=0.023; OR=4.7 and 95% CI 1.7-13.1, P(genotype)=0.003, P(allelic)=0.014; and OR=2.2 and 95% CI 1.1-4.8, P(genotype)=0.04, P(allelic)=0.039 respectively).
|
22902304 |
2012 |
|
Liver diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The distribution of this polymorphism and its impact on the serum level of TNF-α was compared between 90 HCV-infected patients [45 with HCV-induced cirrhosis and 45 with HCV-related hepatocellular carcinoma (HCC)] and 45 healthy Egyptian volunteers without any history of liver disease.
|
22200181 |
2012 |
|
Liver diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor (TNF) has been implicated in the progression of many chronic liver diseases leading to fibrosis; however, the role of TNF in fibrogenesis is controversial and the specific contribution of TNF receptors to hepatic stellate cell (HSC) activation remains to be established.
|
21523796 |
2011 |
|
Liver diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In this study, we tested the hypothesis that blocking TNF action with an anti-TNF monoclonal antibody (CNTO5048) will slow the progression of NPC liver disease.
|
20886067 |
2010 |
|
Liver diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
TNF-alpha exerts its effects by binding to specific receptors (TNFR); the polymorphism of TNFRII T587G has been associated with increased TNF apoptotic response and its presence may increase the risk to develop liver disease.
|
19212208 |
2009 |
|
Liver diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
These data identify an essential role for tnfa in the mutant phenotype and suggest a direct link between SAH-induced methylation defects and TNF expression in human liver disorders associated with elevated TNFalpha.
|
19201949 |
2009 |
|
Liver diseases
|
0.400 |
Biomarker
|
group |
LHGDN |
Role of TNF-alpha produced by nonantigen-specific cells in a fulminant hepatitis mouse model.
|
19109170 |
2009 |
|
Liver diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Inhibiting TNF-alpha expression in the liver by this strategy represents a novel therapeutic approach that may be valuable for the treatment of some inflammation-related liver diseases.
|
19189285 |
2009 |
|
Liver diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The study was aimed at investigating the level of serum TNF-alpha levels in adults and analyzing its relationship with different levels of alcohol consumption, as well as the potential interaction between alcohol consumption and common TNF-alpha gene polymorphisms in relation to TNF-alpha levels and liver disease.
|
18579335 |
2008 |
|
Liver diseases
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Association of TNF-alpha -308 polymorphism with the outcome of hepatitis B virus infection in Turkey.
|
17974504 |
2008 |
|
Liver diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
No significant differences in the distribution of genotypes and alleles of the -308 TNFA gene polymorphism were observed between alcoholics and non-alcoholics, or between alcoholics with liver cirrhosis and those without liver disease.
|
16340448 |
2005 |
|
Liver diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Moreover, NCDase inhibited liver injury and hepatocyte apoptosis in mice treated with D-galactosamine plus TNF-alpha.
|
15946935 |
2005 |
|
Liver diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Involvement of tumor necrosis factor-related apoptosis-inducing ligand and tumor necrosis factor-related apoptosis-inducing ligand receptors in viral hepatic diseases.
|
16226105 |
2005 |