|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results indicated that fenofibrate significantly inhibited the Tlr-4, Myd-88, and Nf-kb1 mRNA expression and TNF-α concentration in B16F10 LPS-stimulated cells.
|
31175545 |
2020 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Given the association of FKBP51 and TRAF2 with TNF-α-induced NF-κB signaling and their correlation in tumor samples, we propose that the two proteins can be exploited as useful markers for the identification of those melanoma tumors that can benefit from TNF-α inhibition.
|
30451787 |
2019 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We observed that activation of PPARγ by its agonist, pioglitazone, reduces tumor volume, Tlr-4, Myd-88, Nf-kb1 mRNA expression, TLR4 protein expression and TNF-α production in melanoma tumor especially in groups that were injected with LPS -stimulated cells.
|
31509504 |
2019 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we identified the tumor necrosis factor-family members, especially Fas, and overloaded intracellular nitric oxide participated in CAP induced apoptosis in A375 and A875 melanoma cell lines, which was known as extrinsic apoptosis pathway.
|
29931745 |
2019 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In our previous work we used MSCs overexpressing gene for tumor necrosis factor α (TNFα; MSCs/TNFα), and we achieved inhibition of melanoma xenograft growth when engineered MCSs/TNFα were coinjected with tumor cells subcutaneously.
|
28043149 |
2019 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The Cd contents, expression of melanoma-associated differentiation gene 5 (MDA5) and its downstream signaling molecules (interferon promoter-stimulating factor 1 (IPS-1), transcription factors interferon regulatory factor 3 (IRF3), and nuclear factor kappa-light chain-enhancer of activated B cells (NF-κB)), the content of cytokines (interleukin 1β (IL-1β), interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α) and beta interferon (IFN-β)), protein levels of heat shock proteins (HSPs), levels of malondialdehyde (MDA), activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD), and histopathological changes of spleens were detected on the 20th, 40th, and 60th day.
|
29032405 |
2018 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The effects of ethanol extract on reactive oxygen species production, apoptosis, and tumor necrosis factor-α secretion were also evaluated on HT-144 cell lines.
|
30028780 |
2018 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immune cells responsive to TNF-α IL-2 were studied using an immunocompetent mouse melanoma model (B16.OVA) infused with ovalbumin-specific T (OT-I) cells.
|
30017877 |
2018 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Melanoma exosomes induced the M1 and M2 representative cytokines TNF-α and IL-10 respectively.
|
29459345 |
2018 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
TNFα mediated ceramide generation triggers cisplatin induced apoptosis in B16F10 melanoma in a PKCδ independent manner.
|
30701020 |
2018 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Sensitization of recombinant human tumor necrosis factor-related apoptosis-inducing ligand-resistant malignant melanomas by quercetin.
|
29596115 |
2018 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Three days post-mRNA electroporation of CD8 TILs, caCD40 elevated IFN-γ and TNF-α production and cytolytic activity in the presence of autologous but not HLA-I-mismatched melanoma.
|
30305327 |
2018 |
|
melanoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Some studies have reported a possible association between exposure to tumour necrosis factor (TNF) inhibitors and an increased risk of melanoma.
|
27307502 |
2017 |
|
melanoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We performed a meta-analysis to assess the relationship between single nucleotide polymorphisms in the TNF-α promoter region (rs1800629 and rs361525) and susceptibility to squamous cell carcinoma (SCC), basal cell carcinoma (BCC) and melanoma.
|
28881857 |
2017 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we report that Ca2+ protects malignant melanoma (MM) and osteosarcoma (OS) cells from tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) cytotoxicity.
|
28560396 |
2017 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, gene expression of interleukin-6 (IL-6), interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) was analyzed in all groups and in subjects affected by both melanoma and psoriasis (MP).
|
26632958 |
2017 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
NFATc2 silencing suppressed TNF-α expression, and neutralization of melanoma-expressed TNF-α promoted melanoma differentiation.
|
26387540 |
2016 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Currently, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is showing promising clinical responses, however its use is hampered by intrinsic or acquired melanoma resistance to apoptosis.
|
26122536 |
2015 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
TNF seems to be a negative prognostic factor in melanoma surgery and correlates with chemotherapy resistance.
|
26279161 |
2015 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The death ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) represents a promising strategy for melanoma due to significant expression of TRAIL receptor 1 in melanoma metastases and high TRAIL sensitivity through this receptor.
|
26134947 |
2015 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The tumour suppressing effect of AT-MSC/hTNFα on A375 melanoma xenografts was monitored in an immunodeficient mouse model in vivo.
|
25677845 |
2015 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In tumors, five genes (KIT, MGMT, MITF, TERT, and TNF) exhibited methylation levels significantly different between tumor groups including acral compared to nonacral melanomas and matched primary lesions and metastases.
|
26106605 |
2015 |
|
melanoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We identified DNA copy-number gain and constitutive ubiquitination by a TNFα autocrine loop mechanism as two mechanisms of RIP1 upregulation in human melanomas.
|
25724678 |
2015 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In particular, we identified macrophage-derived TNFα as a crucial melanoma growth factor that provides resistance to MAPK pathway inhibitors through the lineage transcription factor MITF (microphthalmia transcription factor).
|
25256614 |
2014 |
|
melanoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results of our study suggest that FAN through promoting melanoma cellular motility and tumour invasiveness is critical for the tumour-promoting action of TNF.
|
23674089 |
2013 |