|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
TNF-α, a pro-inflammatory cytokine is one of the major contributors for metabolic syndromes including insulin resistance, obesity, type II diabetes etc.
|
31476685 |
2020 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
As a member of the tumor necrosis factor-α-related protein family, complement-1q tumor necrosis factor-α-related protein isoform 5 (CTRP5) has been found to be associated with obesity and insulin resistance (IR).
|
31070007 |
2020 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude hypoxia or obesity induces release of inflammatory TNFα and MCP-1 from mice primary adipocytes but the two environmental conditions do not synergize to worsen macrophage signal transduction or insulin responsiveness.
|
31677795 |
2020 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the present study illustrates the relationship between TNF-α polymorphism, the degree of inflammation assessed by serum high sensitivity C-reactive protein concentration (CRP-hs) and basal DNA damage in patients with obesity (BMI 30-34.9 kg/m<sup>2</sup>) and control subjects with proper body mass (BMI < 25 kg/m<sup>2</sup>).
|
30900134 |
2020 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
ADIPOQ G rs266729 and TNF- 308 A allele are associated with obesity, MetS/NAFLD and insulin resistance.
|
31659105 |
2020 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We analysed the levels of cytokines (tumour necrosis factor [TNF] α and interleukins [ILs] 1β, 4, 6 and 10), chemokines (stromal cell derived factor 1α, monocyte chemoattract protein [MCP] 1, eotaxin and fractalkine) and growth factors (brain-derived neurotrophic factor, pro-fibrotic platelet-derived growth factor [PDGF-BB] and insulin-like growth factor 1) in serum of prepubertal children with obesity (61 girls/59 boys, 50% IR and 50% non-IR) and 32 controls.
|
30350467 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Proinflammatory macrophages impair skeletal muscle differentiation in obesity through secretion of tumor necrosis factor-α via sustained activation of p38 mitogen-activated protein kinase.
|
30264458 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The increased levels of adipokines such as Leptin, IL-6 and TNF-α and decreased adiponectin were found among obese-T2DM, when compared to non-obese T2DM subjects.
|
30904536 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Obesity and chronic kidney disease progression-the role of a new adipocytokine: C1q/tumour necrosis factor-related protein-1.
|
31198543 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
TNF α, pro-inflammatory cytokine is associated with obesity, insulin resistance and hyperandrogenism, therefore in present study we tried to find the association between TNF α promoter polymorphisms, TNF α levels and the risk of PCOS.
|
30442458 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Obesity is associated to a low-grade inflammation that alters the expression of adiponectin, leptin, IL-6, Monocyte Chemotactic Protein 1 (MCP1), TRAIL, LIGHT/TNFSF14, OPG, and TNFα.
|
31130918 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Effects of oral Nigella sativa oil on the expression levels and serum concentrations of adiponectin, PPAR-γ, and TNF-α in overweight and obese women: a study protocol for a crossover-designed, double-blind, placebo-controlled randomized clinical trial.
|
31420057 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Individuals with class III obesity with higher morphological severity of NAFLD exhibited higher BMI and higher IL-6 and TNF-α expression in the WAT.
|
27083404 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Background The objective of this study was to investigate the association of polymorphisms in four genes, tumor necrosis factor-α (TNFA), patatin-like phospholipase domain containing 3 (PNPLA3), adiponectin (ADIPOQ) and apolipoprotein C3 (APOC3), with obesity and non-alcoholic fatty liver disease (NAFLD) in Asian Indian adolescents.
|
31216264 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Altogether, these results suggest that basolateral TNF-α, which can be produced by adipocytes and macrophages during obesity, would be able to activate TNF-α and other proinflammatory proteins expression in the small intestine and diminish intestinal sugar and amino acids transport.
|
30246472 |
2019 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Circulating TNF-α and the acylated/desacyl ghrelin ratio were increased, whereas desacyl ghrelin levels were decreased in patients with obesity and NAFLD.
|
30137403 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
There was also no significant impact of obesity on CNA-induced TNFα responses in children or from cord blood of infants born to overweight/obese mothers.
|
30909151 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Salivary interleukin (IL)-1-receptor antagonist (IL-1Ra), IL-6, IL-8, IL-10, and tumor necrosis factor (TNF)-α concentrations were measured from 287 non-diabetic obese (body mass index (BMI) of >35 kg/m<sup>2</sup>) individuals and 293 normal-weight (BMI of 18.5-25 kg/m<sup>2</sup>) controls.
|
31817464 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Obese-ALI animals, compared to Obese-SAL, exhibited increased interventricular septum thickness (<i>p</i> = 0.003) and posterior wall thickness (<i>p</i> = 0.003) and decreased pulmonary acceleration time to pulmonary ejection time ratio (<i>p</i> = 0.005); no changes in lung mechanics, IL-6, TNF-α, TGF-β, PCIII, and PCI in lung tissue; increased IL-10 levels in lung homogenate (<i>p</i> = 0.007); reduced MCP-1 expression in blood neutrophils (<i>p</i> = 0.009); decreased TNF-α expression in blood (<i>p</i> = 0.02) and BALF (<i>p</i> = 0.008) neutrophils; and increased IL-10 expression in monocytes (<i>p</i> = 0.004).
|
31275296 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Type 2 diabetes: In a preclinical study in rats where obesity was alimentary induced, the administration of BE significantly reduced food intake, overweight, proinflammatory cytokines such as interleukin-1ß (IL-1ß), and tumor necrosis factor-α (TNF-α) and ameliorated the parameters of glucose and lipid metabolism.
|
31301539 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Biliverdin treatment reversed the higher gene expression of Cd11c, encoding an M1 macrophage marker, and Tnfa, encoding the proinflammatory cytokine tumor necrosis factor-α, in the adipose tissues of DIO mice.
|
31577826 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Obesity had a negative impact on improvement in the DAS with 28 joints using ESR as an inflammation marker of -0.15 (95% CI: -0.26; -0.04) units for women receiving conventional synthetic DMARDs, -0.22 (95% CI: -0.31; -0.12) units for women receiving TNF inhibitors, -0.22 (95% CI: -0.42; -0.03) units for women receiving tocilizumab and -0.41 (95% CI: -0.74; -0.07) units for men receiving tocilizumab.
|
31745566 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Excessive formation of tumor necrosis factor-α (TNF-α), a pro-inflammatory cytokine, has been implicated in the development of insulin resistance in obesity and type-2 diabetes.
|
29955954 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Leptin, adiponectin, tumor necrosis factor α, and irisin concentrations as factors linking obesity with the risk of atrial fibrillation among inpatients with cardiovascular diseases.
|
31553329 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Lastly, serum EDA level was dependent on BMI, TNF-α, T2DM and obesity.
|
31526774 |
2019 |