|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
TNF-α in gingival crevicular fluid, despite the minimal amounts collected, is a good biomarker of periodontal disease; since levels of TNF-α increases with the increase of the most harmful species to the periodontium.
|
31214897 |
2020 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Increased GCF HIF-1α, VEGF, and TNF-α levels in both chronic and aggressive form of periodontitis might suggest the role of TNF-α/HIF-1α/VEGF pathway in the pathogenesis of periodontal diseases.
|
30536725 |
2019 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
During chronic inflammation from diseases, such as periodontal disease, the proinflammatory cytokines interferon-gamma (IFN<i>γ</i>) and tumor necrosis factor-<i>α</i> (TNF<i>α</i>) alter bone remodeling.
|
30158833 |
2018 |
|
Periodontal Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Animals with PD showed higher levels of TNF-α and lower levels of IL-10, when compared to animals without PD.
|
30405072 |
2018 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The aim of this study was to investigate the serum markers osteopontin (OPN), tumor necrosis factor receptors 1 (TNFR1) and 2 (TNFR2) receptor activator of nuclear factor-kappa B ligand (RANKL) and RANKL/ osteoprotegerin (OPG) ratio and compare them in PD and RA groups.
|
29889832 |
2018 |
|
Periodontal Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Elevated levels of TNF-α were confirmed to be associated with the severity of periodontal disease.
|
28946056 |
2018 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These results revealed that IL-6 and TNF-α salivary biomarkers provide high discriminatory capacity for distinguishing periodontal disease from periodontal health in pregnant women.
|
29740515 |
2018 |
|
Periodontal Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results suggest that MERT efficiently prevents IR, improves lipid profile, and increases plasma levels of insulin and TNF in PD and PNX rats.
|
30321542 |
2018 |
|
Periodontal Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Aims of the study are to determine serum and gingival crevicular fluid (GCF) endocan levels in the pathogenesis of periodontal diseases, supported with vascular endothelial growth factor (VEGF-A) and tumor necrosis factor (TNF)-alpha levels.
|
27976595 |
2017 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumour necrosis factor (TNF)-α is a pathological factor causing the characteristic symptoms of periodontal disease and rheumatoid arthritis.
|
28833486 |
2017 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
PKR prevented tumor necrosis factor-α- and interleukin 1α-induced bone resorption in calvaria and artificially induced periodontal disease in rat.
|
27987116 |
2017 |
|
Periodontal Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Periodontal disease is caused by inflammation induced by Porphyromonas gingivalis (P.g.) lipopolysaccharide (LPS) and involves expression of proinflammatory cytokines such as interleukin (IL)-1, IL-6, tumor necrosis factor-α, and receptor activator of nuclear factor kappa B ligand (RANKL), which are implicated in bone resorption.
|
28637991 |
2017 |
|
Periodontal Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
β-glucan reduced plasmatic levels of TNF-α in diabetic animals with PD and of IL-10 in animals with PD (<i>p</i> < 0.05).
|
28906456 |
2017 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Inflammatory cytokines, interleukin (IL)-1, IL-6, and TNF-α, are involved in inflammatory bone diseases such as rheumatoid osteoarthritis and periodontal disease.
|
28063227 |
2017 |
|
Periodontal Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The aim was to assess the effect of SRP with and without adjunct Nd:YAG laser therapy on clinical periodontal parameters and GCF interleukin 1-beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) levels among patients with PD.
|
28282558 |
2017 |
|
Periodontal Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Trained animals with PD presented lower TNF-α expression in periodontal tissues while IL-10 was increased.
|
28800160 |
2017 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The main purpose of this study is to determine genotype abundance of TNF-α-1031 gene in both groups of patients and controls, and also investigation of relation of single nucleotide polymorphism (SNP) these genotypes with periodontal disease risk.
|
27755954 |
2016 |
|
Periodontal Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The purpose of this study was to determine the differences in the distribution of TNF-α (-308) gene polymorphism among aggressive periodontitis, chronic periodontitis and periodontally healthy individuals and also to investigate whether this polymorphism is associated with gingival crevicular fluid TNF-α levels and periodontal disease severity.
|
25647273 |
2015 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumour necrosis factor-alpha (TNF-α) plays a critical role in the pathogenesis of periodontal disease.
|
24905365 |
2014 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Association between tumor necrosis factor-α promoter -308 A/G, -238 A/G, interleukin-6 -174 G/C and -572 G/C polymorphisms and periodontal disease: a meta-analysis.
|
23657600 |
2013 |
|
Periodontal Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, the DNA methylation alteration within the TNFA promoter in human gingival biopsies from different stages of periodontal disease is investigated and the regulatory mechanism of TNFA transcription by DNA methylation is explored.
|
23368949 |
2013 |
|
Periodontal Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The importance of genetic variants in TNFα for periodontal disease in a cohort of coronary patients.
|
22691114 |
2012 |
|
Periodontal Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Despite these differences, our overall findings indicate no differences in the expression levels of the cytokines IL-1β, IL-6, TNF-α, and iNOS in pregnant women with and without periodontal disease in comparison with expression of the same genes in non-pregnant women with and without periodontal disease, suggesting that periodontal disease is not influenced by pregnancy.
|
23079986 |
2012 |
|
Periodontal Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This study investigated whether the prolonged survival of inflammatory cells in periodontal disease could be due to the inhibition of apoptosis by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptors and inhibition of the terminal stages of apoptosis signaling by inhibitor of apoptosis (IAP) family members.
|
19948942 |
2010 |
|
Periodontal Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and -8, and monocyte chemotactic protein (MCP)-1 plus key CC chemokine receptors (CCR1 through 5) and CXC chemokine receptors (CXCR1 through 3) was quantified by real-time polymerase chain reaction (PCR) in gingival or peri-implant biopsies from 135 patients with well-controlled or poorly controlled diabetes and periodontal disease, 65 patients with periodontal disease but otherwise healthy, and 90 systematically and periodontally healthy subjects.Western blots were performed.
|
20059422 |
2010 |