|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Kaempferol reduced CD3<sup>+</sup> T cell infiltration and gene expression of major proinflammatory cytokines, including interleukin (IL)-6, IL-17A and tumor necrosis factor (TNF)-α, in the psoriatic skin lesion.
|
31407330 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to investigate the anti-atopic effects of UMB on 2,4-dinitrochlorobenzene (DNCB)- and house dust mite extract (Dermatophagoides farinae extract, DFE)-treated mice with AD-like skin lesions and on tumor necrosis factor (TNF)-α/interferon (IFN)-γ-treated HaCaT cells.
|
31437788 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of TNF-α in palmoplantar pustulosis increased after anti-TNF-α therapy in the two examined patients with exacerbated skin lesions.
|
29611085 |
2019 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The mRNA and protein expression levels in human and mouse skin lesions and TNF‑α‑stimulated HaCaT cells were detected using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) and western blotting, and compared with the control groups.
|
31017270 |
2019 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, Cal/BDP significantly suppressed the interleukin (IL)-23/IL-17-producing T (T17) pathogenic axis, including expression of IL-17a, IL-23a, IL-22 and TNF-α mRNA in skin lesions and expansion of CCR6<sup>+</sup> γδ T17 cells in the draining lymph nodes.
|
31705000 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
It was found that genistein can significantly improve IMQ-induced pathological scores of cutaneous skin lesions in mice, reduce epidermal thickness, and inhibit the expression of inflammatory factors，including interleukin (IL)-1β, IL-6, tumour necrosis factor-alpha (TNF-α), chemokine ligand 2 (CCL2), IL-17 and IL-23.
|
30743203 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, C5aR1 deficiency significantly decreased IMQ-induced infiltration of plasmacytoid dendritic cells (pDCs), monocytes and neutrophils in psoriatic skin lesions and functions of pDCs, evidenced by the remarkable reduction in the IMQ-induced production of interferon-α (IFN-α) and tumor necrosis factor α (TNF-α), and FMS-like tyrosine kinase 3 ligand (FLT3L)-dependent pDCs differentiation.
|
31447855 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor inhibitors decrease the risk of cardiovascular events in moderate to severe psoriasis, but the association between their effects on endothelial function and those on skin lesions has not been well studied.
|
30168849 |
2019 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
High concentrations of tumor necrosis factor-alpha (TNFα) are found in the skin lesions and plasma of patients with psoriasis.
|
28272075 |
2019 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The following were assessed: dermatitis severity scores; ear and dorsal skin haematoxylin and eosin staining; interleukin (IL)- 1α, IL-1β, IL-2, IL-4, IL-6, and tumour necrosis factor (TNF)-α cytokine levels in the serum; spleen index; spleen CD4 + /CD8 + T lymphocyte ratio; and phosphorylation levels of mitogen-activated protein kinases (MAPKs- p38, extracellular signal-regulated kinase (ERK), and c-Jun N-terminal kinase (JNK)), IκB-α, and nuclear factor (NF)-κB (p65) in skin lesions.
|
29698775 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We first found that IL-1β and TNF-α mRNA expression was significantly decreased in the skin lesions treated with DDH-1.
|
30503675 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Macroscopic and microscopic evaluation of skin lesions was performed together with measurements of serum levels of interleukin (IL)-1β, IL-6, tumour necrosis factor alpha (TNF-α), IL-17, IL-22, IL-10 and IL-4.
|
29409331 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
CRT effectively mitigated the secretion of pro‑inflammatory cytokines, including tumor necrosis factor‑α and interleukin 1β, as well as immune cell infiltration into skin lesions in a mouse model of AD‑like skin disease induced by dinitrochlorobenzene.
|
29845271 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
SP treatment significantly reduced the infiltration of mast cells and CD3-positive T cells as well as inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and thymic stromal lymphopoietin (TSLP), in AD-like skin lesions and decreased the levels of IgE and thymus and activation-regulated chemokine in serum.
|
28833499 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
In the present study, the anti‑AD effects of a 70% ethanol extract of TAEE were investigated in 2,4‑dinitrochlorobenzene (DNCB)‑treated mice with AD‑like skin lesions and in tumor necrosis factor (TNF)‑α‑ and interferon (IFN)‑γ‑stimulated human keratinocytes (HaCaT cells).
|
30066901 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The mRNA expression in blood and skin lesion for TNF, IFN-γ, IL-1β, IL-6, and IL-17A significantly reduced in patients with ENL after treatment, while mRNA expression for IL-10 and TGF-β was significantly increased both in blood and skin lesion after treatment.
|
29479352 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression levels of PGRN and TNF-α were elevated in LSc skin lesions compared with healthy control skin.
|
30268392 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
ASC-exosomes also significantly reduced mRNA expression of various inflammatory cytokines such as interleukin (IL)-4, IL-23, IL-31, and tumor necrosis factor-α (TNF-α) in AD skin lesions of Nc/Nga mice.
|
29996938 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
BS significantly reduced the protein and mRNA expression of TSLP, IL-6, and tumor necrosis factor-α in the AD skin lesions.
|
29455734 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Assessment of the concentration of the proinflammatory cytokines (IL-12, IL-23, IL-17 and TNF-α) in blood serum and their correlation with the intensity of skin lesions, the presence of psoriatic arthritis and the risk of development of obesity and metabolic syndrome.
|
30206447 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis of anti-tumour necrosis factor-induced skin lesions reveals strong T helper 1 activation with some distinct immunological characteristics.
|
29143979 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
We analyzed the presence of M4 macrophage markers (CD68, MRP8, MMP7, IL-6, and TNF-α) in 33 leprosy skin lesion samples from 18 patients with tuberculoid leprosy and 15 with lepromatous leprosy by immunohistochemistry.
|
30442123 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously identified 6-sulfo LacNAc-expressing monocytes (slanMo) as TNF-α- and IL-23-producing cells in psoriatic skin lesions and as inducers of IFN-γ-, IL-17-, and IL-22-producing T cells.
|
29977237 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
CCL27 may act early in the course of disease, via the circulation, whereas TNF-α acts throughout the course of disease, in skin lesions.
|
29713456 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Ethanolic Extracts of <i>Artemisia apiacea</i> Hance Improved Atopic Dermatitis-Like Skin Lesions In Vivo and Suppressed TNF-Alpha/IFN-Gamma⁻Induced Proinflammatory Chemokine Production In Vitro.
|
29932162 |
2018 |