Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
BCG-infection also induced the expression of TNF receptor 2 on CD3<sup>+</sup> myeloid cells, which increased after BCG-infection, suggesting that the tmTNF/TNFRs axis plays an important role in the presence or function of these cells in tuberculosis.
|
31787969 |
2019 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, the levels of <i>SIRT3</i> and <i>PPARA</i> were downregulated and inversely correlated with <i>TNF</i> (tumor necrosis factor) levels in peripheral blood mononuclear cells from tuberculosis patients.
|
30774023 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To increase our understanding of immune response to M. tuberculosis infection, we conducted a cross-sectional study investigating M. tuberculosis infection status and comparing the release profiles of cytokines GM-CSF, IFN-γ, IL-1β, IL-10, IL-12 (p70), IL-2, IL-4, IL-5, IL-6, IL-8, TNF-α, in community controls (CCs) and healthy healthcare workers (HCWs) highly exposed to TB.
|
31160610 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We report the case of successfully treated a patient with reactive arthritis induced by active extra-articular tuberculosis with a TNF inhibitor after sufficient antitubercular treatment.
|
31804308 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients on anti-tumor necrosis factor were more likely to develop TB.
|
30168281 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study aimed to evaluate the prevalence of LTBI and the number of active TB cases in patients with inflammatory bowel disease (IBD) treated with anti-TNF agents.
|
31206406 |
2019 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This is a cross-sectional study of cases and controls in which polymorphisms at -174 in IL-6, -238 and -308 in TNF-α were identified in healthy subjects, those with TB, T2DM and carriers of the comorbidity, each group consisted of 30 individuals.
|
30917933 |
2019 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multiple administrative databases were linked to identify people with risk factors who met the WHO strong recommendations for screening: people with tuberculosis (TB) contact, with human immunodeficiency virus, on dialysis, with tumor necrosis factor-alpha inhibitors, who had an organ/haematological transplant, or with silicosis.
|
30856258 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study evaluated the diagnostic performances of the IFN-γ and TNF-α dual release fluorospot assay for active TB.
|
31730906 |
2019 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, SNPs of the IL1B and TNF gene were associated with TB susceptibility in Chinese Han and Tibetan populations.
|
30792445 |
2019 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using cohorts of HIV-infected and HIV-uninfected individuals with latent Mtb infection (LTBI) and with active TB disease, we stimulated peripheral blood mononuclear cells (PBMC) for 6 hours with Mtb peptide pools and evaluated co-expression profiles of the inhibitory receptors BTLA, CTLA-4, and PD-1 on IFN-γ<sup>+</sup>/TNF-α<sup>+</sup> Mtb-specific CD4 T cells.
|
31497018 |
2019 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, mycobacterial antigen-stimulated responses with IL-1ra, IL-10 and TNF-α were higher in participants with active TB compared those with LTBI, reaching statistical significance with PPD stimulation, although there was a degree of overlap between the two groups.
|
30711163 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Concentration of leptin was significantly lower, while TNF-α higher in TB patients with SVDD compared to those without (p<0.05).
|
31666475 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, side effects of TNF-α inhibition have been reported, particularly in the form of exacerbation of infections such as tuberculosis.
|
31620105 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The risk of TB with TNF inhibitor was higher than with a non-TNF biologic (hazard ratio 4.34; 95% CI 1.31-14.39), while the risk of infliximab was higher than etanercept and adalimumab (hazard ratio: 4.10 and 2.08, respectively).
|
30561745 |
2019 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Intratracheal administration of only one dose of AdIL-12 one day before Mtb infection produced significant decrease of bacterial loads, lesser pneumonia and higher expression of TNF-α, IFN-γ and iNOS.
|
30548932 |
2019 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Neutrophils can express cytokines that influence TB progression, and so we compared neutrophil and T-cell expression of the Th1 cytokines IFNγ and TNF, the Th2 cytokine IL-4, and regulatory cytokine IL-10 in M. tuberculosis-infected macaques to determine if neutrophil cytokine expression contributes to dysregulated immunity in TB.
|
31434990 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accordingly, we examined the impact of individual versus combined neutralization of TNF-α and IL-17A in a mouse model of rheumatoid arthritis (collagen-induced arthritis) and the concomitant susceptibility to infections that are likely to manifest as side effects of blocking these cytokines (oral candidiasis or tuberculosis).
|
30745461 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tuberculosis and Biologic Therapies: Anti-Tumor Necrosis Factor-α and Beyond.
|
31731980 |
2019 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To estimate the incidence of tuberculosis in patients receiving TNF inhibitors therapy for rheumatic diseases.
|
31790428 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF Induces Pathogenic Programmed Macrophage Necrosis in Tuberculosis through a Mitochondrial-Lysosomal-Endoplasmic Reticulum Circuit.
|
31474371 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Baseline TB screening tests (purified protein derivative test and/or QuantiFERON-TB Gold test) were performed on all patients before initiation of anti-TNF therapy.
|
30964811 |
2019 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The multiple adverse effects of TNF-α inhibition have been identified, including a two-to four-fold increased risk of active tuberculosis and other granulomatous conditions and an increased occurrence of some other serious bacterial, fungal and certain viral infections.
|
30732563 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the discovery cohort, the AUC of the 8-marker biosignature (eotaxin, MIP-1α, MDC, IP-10, MCP-1, IL-1α, IL-10, and TNF-α) in diagnosing ATB was 1.0.
|
30528869 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Latent tuberculosis infection screening in juvenile idiopathic arthritis patients preceding anti-TNF therapy in a tuberculosis high-risk country.
|
29037310 |
2019 |