TNF, tumor necrosis factor, 7124

N. diseases: 2724; N. variants: 31
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0043144
Disease: Wheezing
Wheezing
0.090 AlteredExpression phenotype BEFREE Serum levels of Tumor Necrosis Factor-α (TNF-α), Monocyte chemotactic protein-1 (MCP-1), Vascular endothelial growth factor (VEGF), Epidermal growth factor (EGF), forced expiratory volume-one second (FEV<sub>1</sub>) and respiratory symptoms including; Chest wheeze (CW), night wheeze (NW), night cough (NC) and cough and wheeze during exercise (ECW) were assessed at the baseline (step 0), one and two months after starting treatment (step I and II, respectively). 30961947 2019
CUI: C0043144
Disease: Wheezing
Wheezing
0.090 GeneticVariation phenotype BEFREE GSTP1 rs1138272 and TNF rs1800629 SNPs were associated with asthma and wheeze, respectively. 24465030 2014
CUI: C0043144
Disease: Wheezing
Wheezing
0.090 GeneticVariation phenotype BEFREE We can conclude that genetic variation in TNF-α-308G/A may contribute to childhood asthma and wheezing. 23376082 2013
CUI: C0043144
Disease: Wheezing
Wheezing
0.090 GeneticVariation phenotype BEFREE Home dampness is a risk factor for asthma and wheeze among children, especially for those with the TNF-308 A allele. 21307151 2011
CUI: C0043144
Disease: Wheezing
Wheezing
0.090 GeneticVariation phenotype BEFREE For example, the odds ratio (OR) for developing early wheeze related to early maternal smoking was 2.4 [95% confidence interval (CI) 1.6-3.7] in children with a wild-type CC homozygote genotype of the TNF-857 SNP, while no tobacco-related risk was seen in children carrying the rare T allele. 20210814 2010
CUI: C0043144
Disease: Wheezing
Wheezing
0.090 GeneticVariation phenotype BEFREE For three polymorphisms: CYP1A1*2A, CYP1A1*2B, and TNF -308 there was a pattern consistent with interaction between genotype and TDI exposure status for the majority of symptoms investigated, although it did reach statistical significance only for some symptoms: among TDI-exposed workers, the CYP1A1 variant carriers had increased risk (CYP1A1*2A and eye symptoms: variant carriers OR 2.0 95% CI 0.68-6.1, p-value for interaction 0.048; CYP1A1*2B and wheeze: IV carriers OR = 12, 1.4-110, p-value for interaction 0.057). 18447907 2008
CUI: C0043144
Disease: Wheezing
Wheezing
0.090 GeneticVariation phenotype BEFREE Children with TNF-308 GG had decreased risk of asthma (odds ratio, 0.8; 95% confidence interval, 0.7-0.9) and lifetime wheezing (odds ratio, 0.8; 95% confidence interval, 0.7-0.9). 16456144 2006
CUI: C0043144
Disease: Wheezing
Wheezing
0.090 Biomarker phenotype BEFREE Haplotype analysis showed that TNF-alpha-308G, LT-alpha+252A/TNF-alpha-308A, LT-alpha+252A was associated with a markedly increased risk for both asthma and infant wheezing. 16204594 2005
CUI: C0043144
Disease: Wheezing
Wheezing
0.090 GeneticVariation phenotype BEFREE In girls, the OR for the TNFA-308A allele and wheeze in the last 12 months was 3.6 (P = 0.01) and for current asthma it was 6.0 (P = 0.0006). 15137526 2004